Zoetis (ZTS)
Market Price (12/4/2025): $120.64 | Market Cap: $53.4 BilSector: Health Care | Industry: Pharmaceuticals
Zoetis (ZTS)
Market Price (12/4/2025): $120.64Market Cap: $53.4 BilSector: Health CareIndustry: Pharmaceuticals
Investment Highlights
Why It Matters
Which of these 2 stories sounds closer for this stock?
1. Generates cash flow
The stock generated 4% or more of the share price (called cash flow yield), and shows moderate 10-15% or more growth.
2. Riding a trend
Think Tesla during the pandemic of 2020 when EVs were riding a cultural high, or Nvidia in the current AI boom, or even Figma. These companies don’t have enough yield, or, enough growth, or both - however - they are riding a trend. They have momentum. These can be more volatile - they don’t have the floor of strong cash flow
| Megatrend and thematic driversMegatrends include Biotechnology & Genomics, Precision Medicine, and Aging Population & Chronic Disease. Themes include Advanced Diagnostics, Show more. |
| Megatrend and thematic driversMegatrends include Biotechnology & Genomics, Precision Medicine, and Aging Population & Chronic Disease. Themes include Advanced Diagnostics, Show more. |
Valuation, Metrics & Events
ZTS Stock
Why The Stock Moved
Qualitative Assessment
AI Generated Analysis | Feedback
Here are five key points explaining the approximate -21.4% movement of Zoetis (ZTS) stock from August 31, 2025, to December 4, 2025:
1. Zoetis reported mixed third-quarter 2025 earnings, with a revenue miss and lowered full-year guidance. Despite beating adjusted earnings per share (EPS) estimates with $1.70 against a forecast of $1.62, the company's reported revenue of $2.4 billion slightly missed the anticipated $2.41 billion. More significantly, Zoetis lowered its fiscal 2025 sales guidance from an earlier projection of $9.45 billion-$9.60 billion to a new range of $9.4 billion-$9.475 billion. This updated guidance, reflecting moderated growth expectations, contributed to a pre-market stock decline of 14.79% following the November 4, 2025, earnings release.
2. The company experienced softening demand for certain animal medicines and vaccines. Zoetis attributed its reduced sales outlook to a general moderation in growth and specifically noted softer demand for its medicines and vaccines targeting livestock, particularly pigs and chickens.
Stock Movement Drivers
Return vs. Risk
Price Returns Compared
| 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total [1] | |
|---|---|---|---|---|---|---|---|
| Returns | |||||||
| ZTS Return | 26% | 48% | -40% | 36% | -17% | -23% | -1% |
| Peers Return | 17% | 8% | -19% | 12% | 9% | 66% | 107% |
| S&P 500 Return | 16% | 27% | -19% | 24% | 23% | 16% | 112% |
Monthly Win Rates [3] | |||||||
| ZTS Win Rate | 67% | 83% | 33% | 67% | 50% | 30% | |
| Peers Win Rate | 58% | 54% | 44% | 50% | 48% | 57% | |
| S&P 500 Win Rate | 58% | 75% | 42% | 67% | 75% | 70% | |
Max Drawdowns [4] | |||||||
| ZTS Max Drawdown | -30% | -13% | -46% | -1% | -26% | -28% | |
| Peers Max Drawdown | -33% | -7% | -38% | -18% | -17% | -23% | |
| S&P 500 Max Drawdown | -31% | -1% | -25% | -1% | -2% | -15% | |
[1] Cumulative total returns since the beginning of 2020
[2] Peers: MRK, IDXX, ELAN, PAHC, LHI. See ZTS Returns vs. Peers.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2025 data is for the year up to 12/3/2025 (YTD)
How Low Can It Go
| Event | ZTS | S&P 500 |
|---|---|---|
| 2022 Inflation Shock | ||
| % Loss | -46.9% | -25.4% |
| % Gain to Breakeven | 88.4% | 34.1% |
| Time to Breakeven | Not Fully Recovered days | 464 days |
| 2020 Covid Pandemic | ||
| % Loss | -36.1% | -33.9% |
| % Gain to Breakeven | 56.4% | 51.3% |
| Time to Breakeven | 119 days | 148 days |
| 2018 Correction | ||
| % Loss | -16.8% | -19.8% |
| % Gain to Breakeven | 20.2% | 24.7% |
| Time to Breakeven | 53 days | 120 days |
Compare to MRK, IDXX, ELAN, PAHC, LHI
In The Past
Zoetis's stock fell -46.9% during the 2022 Inflation Shock from a high on 12/29/2021. A -46.9% loss requires a 88.4% gain to breakeven.
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Asset Allocation
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Latest Trefis Analyses
Trade Ideas
Select past ideas related to ZTS. For more, see Trefis Trade Ideas.
| Date | Ticker | Company | Category | Trade Strategy | 6M Fwd Rtn | 12M Fwd Rtn | 12M Max DD |
|---|---|---|---|---|---|---|---|
| 11142025 | CRL | Charles River Laboratories International | Dip Buy | DB | FCFY OPMDip Buy with High FCF Yield and High MarginBuying dips for companies with high FCF yield and meaningfully high operating margin | 4.1% | 4.1% | -3.7% |
| 11142025 | GDRX | GoodRx | Dip Buy | DB | CFO/Rev | Low D/EDip Buy with High Cash Flow MarginsBuying dips for companies with significant cash flows from operations and reasonable debt / market cap | -9.8% | -9.8% | -11.8% |
| 11142025 | ASTH | Astrana Health | Dip Buy | DB | FCF Yield | Low D/EDip Buy with High Free Cash Flow YieldBuying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap | 6.0% | 6.0% | -5.5% |
| 11142025 | SGRY | Surgery Partners | Dip Buy | DB | FCF Yield | Low D/EDip Buy with High Free Cash Flow YieldBuying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap | 9.7% | 9.7% | -1.4% |
| 11072025 | TFX | Teleflex | Dip Buy | DB | FCFY OPMDip Buy with High FCF Yield and High MarginBuying dips for companies with high FCF yield and meaningfully high operating margin | 6.2% | 6.2% | -5.1% |
| 11072025 | ZTS | Zoetis | Dip Buy | DB | P/E OPMDip Buy with Low PE and High MarginBuying dips for companies with tame PE and meaningfully high operating margin | 3.5% | 3.5% | -3.6% |
| Date | Ticker | Company | Category | Trade Strategy | 6M Fwd Rtn | 12M Fwd Rtn | 12M Max DD |
|---|---|---|---|---|---|---|---|
| 11142025 | CRL | Charles River Laboratories International | Dip Buy | DB | FCFY OPMDip Buy with High FCF Yield and High MarginBuying dips for companies with high FCF yield and meaningfully high operating margin | 4.1% | 4.1% | -3.7% |
| 11142025 | GDRX | GoodRx | Dip Buy | DB | CFO/Rev | Low D/EDip Buy with High Cash Flow MarginsBuying dips for companies with significant cash flows from operations and reasonable debt / market cap | -9.8% | -9.8% | -11.8% |
| 11142025 | ASTH | Astrana Health | Dip Buy | DB | FCF Yield | Low D/EDip Buy with High Free Cash Flow YieldBuying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap | 6.0% | 6.0% | -5.5% |
| 11142025 | SGRY | Surgery Partners | Dip Buy | DB | FCF Yield | Low D/EDip Buy with High Free Cash Flow YieldBuying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap | 9.7% | 9.7% | -1.4% |
| 11072025 | TFX | Teleflex | Dip Buy | DB | FCFY OPMDip Buy with High FCF Yield and High MarginBuying dips for companies with high FCF yield and meaningfully high operating margin | 6.2% | 6.2% | -5.1% |
| 11072025 | ZTS | Zoetis | Dip Buy | DB | P/E OPMDip Buy with Low PE and High MarginBuying dips for companies with tame PE and meaningfully high operating margin | 3.5% | 3.5% | -3.6% |
Research & Analysis
Invest in Strategies
Wealth Management
Peer Comparisons for Zoetis
| Peers to compare with: |
Financials
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Returns
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Comparison Analyses
Segment Financials
Revenue by Segment
| $ Mil | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|
| Parasiticides | 1,947 | 1,860 | 1,635 | 1,173 | 966 |
| Vaccines | 1,771 | 1,718 | 1,673 | 1,476 | 1,483 |
| Dermatology | 1,427 | 1,329 | 1,180 | 941 | 770 |
| Anti-infectives | 1,057 | 1,081 | 1,215 | 1,206 | 1,254 |
| Other pharmaceuticals | 678 | 1,043 | 966 | 821 | 780 |
| Pain and sedation | 602 | ||||
| Animal health diagnostics | 376 | 353 | 374 | 305 | 268 |
| Medicated feed additives | 354 | 360 | 420 | 460 | 470 |
| Other non-pharmaceuticals | 254 | 250 | 231 | 210 | 184 |
| Contract manufacturing & human health | 78 | 86 | 82 | 83 | 85 |
| Total | 8,544 | 8,080 | 7,776 | 6,675 | 6,260 |
Returns Analyses
SEC Filings
Expand for More| Report Date | Filing Date | Filing |
|---|---|---|
| 9302025 | 11042025 | 10-Q 9/30/2025 |
| 6302025 | 8052025 | 10-Q 6/30/2025 |
| 3312025 | 5062025 | 10-Q 3/31/2025 |
| 12312024 | 2132025 | 10-K 12/31/2024 |
| 9302024 | 11042024 | 10-Q 9/30/2024 |
| 6302024 | 8062024 | 10-Q 6/30/2024 |
| 3312024 | 5022024 | 10-Q 3/31/2024 |
| 12312023 | 2132024 | 10-K 12/31/2023 |
| 9302023 | 11022023 | 10-Q 9/30/2023 |
| 6302023 | 8082023 | 10-Q 6/30/2023 |
| 3312023 | 5042023 | 10-Q 3/31/2023 |
| 12312022 | 2142023 | 10-K 12/31/2022 |
| 9302022 | 11032022 | 10-Q 9/30/2022 |
| 6302022 | 8042022 | 10-Q 6/30/2022 |
| 3312022 | 5052022 | 10-Q 3/31/2022 |
| 12312021 | 2152022 | 10-K 12/31/2021 |
External Quote Links
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