Tearsheet

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0

Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -37%

Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 267%

Valuation becoming less expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is -46%

Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, Precision Medicine, and Aging Population & Chronic Disease. Themes include Gene Editing & Therapy, Show more.

Weak multi-year price returns
2Y Excs Rtn is -128%, 3Y Excs Rtn is -121%

Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -136 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -1315%

Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 113%

Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -1311%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -1353%

Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -87%

Key risks
TCRX key risks include [1] significant clinical trial delays and regulatory hurdles for its lead programs and [2] specific efficacy and safety concerns for its lead candidate, Show more.

0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -37%
1 Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 267%
2 Valuation becoming less expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is -46%
3 Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, Precision Medicine, and Aging Population & Chronic Disease. Themes include Gene Editing & Therapy, Show more.
4 Weak multi-year price returns
2Y Excs Rtn is -128%, 3Y Excs Rtn is -121%
5 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -136 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -1315%
6 Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 113%
7 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -1311%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -1353%
8 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -87%
9 Key risks
TCRX key risks include [1] significant clinical trial delays and regulatory hurdles for its lead programs and [2] specific efficacy and safety concerns for its lead candidate, Show more.

Valuation, Metrics & Events

Price Chart

Why The Stock Moved

Qualitative Assessment

AI Analysis | Feedback

TScan Therapeutics (TCRX) stock has gained about 20% since 1/31/2026 because of the following key factors:

1. Significant Clinical Milestones for the Hematologic Malignancies Program.

TScan Therapeutics achieved key advancements in its ALLOHA™ clinical program for hematologic malignancies. On February 26, 2026, the company announced the successful completion of enrollment in Cohort C of its Phase 1 ALLOHA™ trial, where patients are being treated using a new commercial-ready manufacturing process. Concurrently, the FDA cleared Investigational New Drug (IND) applications for TSC-102-A01 and TSC-102-A03, expanding the program to address a broader patient population with specific HLA types (A01:01 and A03:01). These developments, including plans to initiate Phase 1 studies for the TSC-102 candidates in the second half of 2026, underscore progress in TScan's core therapeutic area.

2. Strategic Prioritization and Enhanced Financial Stability.

TScan Therapeutics implemented a strategic prioritization, announced in November 2025, which continued to positively impact its financial outlook in 2026. The company shifted its focus to accelerate the clinical development of its heme program, specifically TSC-101, and paused further enrollment in its solid tumor PLEXI-T trial. This strategic realignment included a workforce reduction of approximately 30% (66 employees), which is projected to generate significant annual cost savings of about $45 million in both 2026 and 2027. These measures are expected to extend the company's cash runway into the second half of 2027, alleviating near-term liquidity concerns.

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Stock Movement Drivers

Fundamental Drivers

The 18.6% change in TCRX stock from 1/31/2026 to 5/5/2026 was primarily driven by a 22.6% change in the company's Total Revenues ($ Mil).
(LTM values as of)13120265052026Change
Stock Price ($)1.021.2118.6%
Change Contribution By: 
Total Revenues ($ Mil)81022.6%
P/S Multiple15.715.2-3.2%
Shares Outstanding (Mil)1301300.0%
Cumulative Contribution18.6%

LTM = Last Twelve Months as of date shown

Market Drivers

1/31/2026 to 5/5/2026
ReturnCorrelation
TCRX18.6% 
Market (SPY)3.6%46.0%
Sector (XLV)-5.7%20.3%

Fundamental Drivers

The -37.6% change in TCRX stock from 10/31/2025 to 5/5/2026 was primarily driven by a -57.9% change in the company's P/S Multiple.
(LTM values as of)103120255052026Change
Stock Price ($)1.941.21-37.6%
Change Contribution By: 
Total Revenues ($ Mil)71048.3%
P/S Multiple36.215.2-57.9%
Shares Outstanding (Mil)130130-0.1%
Cumulative Contribution-37.6%

LTM = Last Twelve Months as of date shown

Market Drivers

10/31/2025 to 5/5/2026
ReturnCorrelation
TCRX-37.6% 
Market (SPY)5.5%34.4%
Sector (XLV)1.6%19.8%

Fundamental Drivers

The -24.6% change in TCRX stock from 4/30/2025 to 5/5/2026 was primarily driven by a -77.9% change in the company's P/S Multiple.
(LTM values as of)43020255052026Change
Stock Price ($)1.601.21-24.6%
Change Contribution By: 
Total Revenues ($ Mil)310266.7%
P/S Multiple68.915.2-77.9%
Shares Outstanding (Mil)121130-6.9%
Cumulative Contribution-24.6%

LTM = Last Twelve Months as of date shown

Market Drivers

4/30/2025 to 5/5/2026
ReturnCorrelation
TCRX-24.6% 
Market (SPY)30.4%31.8%
Sector (XLV)5.3%25.3%

Fundamental Drivers

The -46.7% change in TCRX stock from 4/30/2023 to 5/5/2026 was primarily driven by a -81.5% change in the company's Shares Outstanding (Mil).
(LTM values as of)43020235052026Change
Stock Price ($)2.271.21-46.7%
Change Contribution By: 
Total Revenues ($ Mil)1410-23.7%
P/S Multiple4.015.2276.9%
Shares Outstanding (Mil)24130-81.5%
Cumulative Contribution-46.7%

LTM = Last Twelve Months as of date shown

Market Drivers

4/30/2023 to 5/5/2026
ReturnCorrelation
TCRX-46.7% 
Market (SPY)78.7%19.3%
Sector (XLV)14.4%20.1%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
TCRX Return-57%-66%276%-48%-67%22%-88%
Peers Return8%-28%8%-15%-3%23%-15%
S&P 500 Return27%-19%24%23%16%5%92%

Monthly Win Rates [3]
TCRX Win Rate17%33%75%42%50%80% 
Peers Win Rate42%42%40%50%48%56% 
S&P 500 Win Rate75%42%67%75%67%40% 

Max Drawdowns [4]
TCRX Max Drawdown-57%-67%0%-51%-71%-9% 
Peers Max Drawdown-29%-42%-26%-31%-34%-8% 
S&P 500 Max Drawdown-1%-25%-1%-2%-15%-7% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: GILD, BMY, IOVA, CRSP, NTLA.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 5/5/2026 (YTD)

How Low Can It Go

EventTCRXS&P 500
2025 US Tariff Shock
  % Loss-47.1%-18.8%
  % Gain to Breakeven89.1%23.1%
  Time to Breakeven180 days79 days
2023 SVB Regional Banking Crisis
  % Loss-36.4%-6.7%
  % Gain to Breakeven57.3%7.1%
  Time to Breakeven8 days31 days
2022 Inflation Shock & Fed Tightening
  % Loss-65.1%-24.5%
  % Gain to Breakeven186.7%32.4%
  Time to Breakeven366 days427 days

Compare to GILD, BMY, IOVA, CRSP, NTLA

In The Past

TScan Therapeutics's stock fell -47.1% during the 2025 US Tariff Shock. Such a loss loss requires a 89.1% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

EventTCRXS&P 500
2025 US Tariff Shock
  % Loss-47.1%-18.8%
  % Gain to Breakeven89.1%23.1%
  Time to Breakeven180 days79 days
2023 SVB Regional Banking Crisis
  % Loss-36.4%-6.7%
  % Gain to Breakeven57.3%7.1%
  Time to Breakeven8 days31 days
2022 Inflation Shock & Fed Tightening
  % Loss-65.1%-24.5%
  % Gain to Breakeven186.7%32.4%
  Time to Breakeven366 days427 days

Compare to GILD, BMY, IOVA, CRSP, NTLA

In The Past

TScan Therapeutics's stock fell -47.1% during the 2025 US Tariff Shock. Such a loss loss requires a 89.1% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About TScan Therapeutics (TCRX)

TScan Therapeutics, Inc., a preclinical-stage biopharmaceutical company, develops T cell receptor-engineered T cell therapies for the treatment of patients with cancer. It is developing TSC-100 and TSC-101 for the treatment of patients with hematologic malignancies to eliminate residual leukemia and prevent relapse after hematopoietic stem cell transplantation; and TSC-200, TSC-201, TSC-202, TSC-203, and TSC-204 for the treatment of solid tumors. The company is also developing vaccines for infectious diseases, such as SARS-CoV-2. It has a collaboration and license agreement with Novartis Institutes for BioMedical Research, Inc., to identify novel cancer antigens from the T cells of patients with a certain specific type of cancer. TScan Therapeutics, Inc. was incorporated in 2018 and is headquartered in Waltham, Massachusetts.

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Analogy 1: "An early-stage Moderna or BioNTech, but focused on engineering T-cells to fight cancer rather than primarily developing mRNA vaccines."

Analogy 2: "Like a next-generation Gilead Sciences (Kite Pharma) or Novartis for advanced engineered T-cell cancer treatments."

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  • TCR-engineered T-cell therapies for hematologic malignancies: These therapies, including TSC-100 and TSC-101, are designed to eliminate residual leukemia and prevent relapse after hematopoietic stem cell transplantation.
  • TCR-engineered T-cell therapies for solid tumors: This pipeline includes candidates like TSC-200, TSC-201, TSC-202, TSC-203, and TSC-204 for the treatment of various solid tumor cancers.
  • Vaccines for infectious diseases: The company is also developing vaccines targeting infectious diseases, such as SARS-CoV-2.

AI Analysis | Feedback

TScan Therapeutics (TCRX) is a preclinical-stage biopharmaceutical company, meaning it is focused on research and development and has not yet brought products to market for sale to individuals or healthcare providers. Therefore, its primary "customers" or revenue-generating relationships are typically with other companies through collaborations and licensing agreements.

Based on the provided information, TScan Therapeutics has a significant collaboration and license agreement with:

  • Novartis Institutes for BioMedical Research, Inc. (a subsidiary of Novartis AG, symbol: NVS)

This agreement makes Novartis a major "customer" in the context of TScan Therapeutics' research, technology, and potential future product rights.

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Thermo Fisher Scientific (TMO)

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Gavin MacBeath, Ph.D. Chief Executive Officer Dr. MacBeath was appointed CEO in May 2023, having served as acting CEO since March 2023. He has over two decades of experience in academia and industry, including founding companies and advancing research from early-stage discovery to drug approval. Prior to TScan, he co-founded Merrimack Pharmaceuticals, serving as Senior Vice President of Discovery where he progressed several biologics through IND, Phase 1, and Phase 2 clinical development. He also served as Chief Scientific Officer at Abpro. Dr. MacBeath has co-founded three oncology companies. Jason Amello Chief Financial Officer and Treasurer Mr. Amello joined TScan as Chief Financial Officer and Treasurer in January 2024. He previously served as CFO, Treasurer, and Secretary at Candel Therapeutics, Inc. His extensive experience includes CFO and Treasurer roles at Saniona AB and Akebia Therapeutics, Inc., as well as Executive Vice President, CFO, and Treasurer of Alaunos Therapeutics, Inc. (formerly ZIOPHARM Oncology, Inc.). From 2000 to 2011, Mr. Amello held various finance leadership positions at Genzyme Corporation (acquired by Sanofi), including Senior Vice President and Chief Accounting Officer, where he advised on mergers and acquisitions, including the company's sale to Sanofi for approximately $20 billion. He also served on the Board of Directors of Acer Therapeutics, Inc. Chrystal Louis, M.D., M.P.H. Chief Medical Officer Dr. Louis joined TScan as Chief Medical Officer in April 2024. Before TScan, she was the Senior Vice President of hematology clinical development at Zentalis Pharmaceuticals, Inc. She also served as Vice President, Head of Medical Affairs at CRISPR Therapeutics, Inc. Zoran Zdraveski, J.D., Ph.D. Chief Legal and Strategy Officer and Secretary Dr. Zdraveski has served as TScan's Chief Legal and Strategy Officer and Secretary since September 2021. He brings over 20 years of legal, intellectual property, and business operations experience within the biopharmaceutical industry, with previous tenure at Alnylam Pharmaceuticals, Inc. Justin McCue, Ph.D. Chief Technology Officer Dr. McCue was appointed Chief Technology Officer in December 2023. He has over 20 years of experience in biologics and cell therapy manufacturing, encompassing process/analytical development, technical operations, clinical development, and commercialization of T cell therapy products. Prior to joining TScan, he served as Chief Technology Officer at Avectas, and previously as Vice President of Technical Operations at Repertoire Immune Medicines.

AI Analysis | Feedback

TScan Therapeutics (NASDAQ: TCRX) faces several key business risks inherent to its nature as a clinical-stage biopharmaceutical company. The most significant risk is the **uncertainty of clinical trial outcomes and regulatory approval** for its T cell receptor-engineered T cell (TCR-T) therapies. As a company whose business depends heavily on the success of its proprietary platform, the failure of any of its drug candidates, such as TSC-100, TSC-101, or those targeting solid tumors, in clinical trials or to gain regulatory approval would materially impact its share value and overall viability. The company's pipeline largely remains in early clinical stages, and the inherently speculative nature of biotechnology means most of its intellectual property is largely unproven. Its future largely hinges on the success of its lead hematologic malignancy candidate, TSC-101. Secondly, **financial health and the ongoing need for substantial additional funding** pose a critical risk. TScan Therapeutics has incurred significant losses since its inception and anticipates continuing to incur losses for several more years, with no guarantee of achieving or sustaining profitability. The company's financial challenges are highlighted by a negative earnings per share and net margin, and an Altman Z-Score in the "distress zone," indicating a potential risk of bankruptcy within two years, as of March 2026. Although TScan projects its current capital will sustain operations until the latter half of 2027, it will require substantial additional funding to complete the development and potential commercialization of its product candidates. Failure to raise sufficient capital could force the company to delay, reduce, or eliminate crucial product development programs or commercialization efforts. Finally, **intense competition and the protection of intellectual property** represent a substantial risk. TScan Therapeutics operates in a highly competitive and rapidly evolving biopharmaceutical environment. The company's business relies on its proprietary platform for identifying and developing novel TCR-T therapies, making the establishment and maintenance of intellectual property protection crucial. Competition from other companies developing similar therapies, or the inability to effectively protect its intellectual property, could limit TScan's market share and profitability.

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TScan Therapeutics (TCRX) is anticipated to drive future revenue growth over the next 2-3 years through the following key initiatives:

  1. Advancement and Potential Commercialization of TSC-101 for Hematologic Malignancies: The primary driver of future revenue growth is the progression and potential market entry of TSC-101, a T cell receptor-engineered T cell (TCR-T) therapy for hematologic malignancies. TScan Therapeutics plans to initiate a pivotal trial for TSC-101 for acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) in the second quarter of 2026. Positive clinical trial results and subsequent regulatory approval would be a significant catalyst for commercial revenue generation. Further, preliminary data has shown 100% relapse-free survival in AML patients treated with TSC-101 at two-year follow-up.
  2. Expansion of the Hematologic Malignancies Pipeline: TScan is actively expanding its heme malignancies program beyond TSC-101. The company received FDA clearance for Investigational New Drug (IND) applications for TSC-102-A01 and TSC-102-A03, designed to target CD45 in patients with specific HLA types. A Phase 1 study for these additional candidates is slated to begin in the second half of 2026, broadening the potential patient population and future revenue streams within this prioritized therapeutic area.
  3. Strategic Collaboration and Licensing Agreements: Collaboration and licensing agreements are expected to be a continued source of revenue. In 2025, TScan Therapeutics reported $10.3 million in collaboration and license revenue, primarily driven by timing of activities under its collaboration with Amgen. While a prior collaboration agreement with Novartis concluded in March 2023, ongoing and new partnerships leveraging TScan's proprietary T-cell receptor discovery platform could provide upfront payments, research funding, milestone payments, and royalties, contributing to revenue growth.

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Share Repurchases

TScan Therapeutics (TCRX) has made no share repurchases over the last 3-5 years.

Share Issuance

  • As of December 31, 2025, TScan Therapeutics had 52,625,035 shares of voting common stock and 4,276,588 shares of non-voting common stock outstanding.
  • Including common stock and pre-funded warrants, the pro forma outstanding shares were 129,913,390 as of December 31, 2025.
  • In January 2026, officers Dworak Leiden and Zoran Zdraveski received stock option grants for 100,000 and 350,000 shares, respectively, with an exercise price of $1.12 per share.

Inbound Investments

  • Revenue, primarily from its collaboration agreement with Amgen, increased to $10.3 million for the full-year 2025, up from $2.8 million in 2024.
  • The company held $152.4 million in cash and cash equivalents as of December 31, 2025, which is projected to fund operations into the second half of 2027.

Capital Expenditures

  • Capital expenditures for 2025 amounted to $4.4 million.
  • Research and development (R&D) expenses were $114.2 million for the full-year 2025, an increase from $107.4 million in 2024, reflecting a significant allocation towards its clinical programs.
  • TScan anticipates the need for substantial additional funding to complete the development and potential commercialization of its product candidates.

Better Bets vs. TScan Therapeutics (TCRX)

Latest Trefis Analyses

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Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
GEHC_4302026_Dip_Buyer_FCFYield04302026GEHCGE HealthCare TechnologiesDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
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IQV_4302026_Dip_Buyer_FCFYield04302026IQVIQVIADip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
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UHS_4302026_Dip_Buyer_FCFYield04302026UHSUniversal Health ServicesDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
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ABT_4302026_Dip_Buyer_ValueBuy04302026ABTAbbott LaboratoriesDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
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ZBIO_4302026_Insider_Buying_45D_2Buy_200K04302026ZBIOZenas BioPharmaInsiderInsider Buys 45DStrong Insider Buying
Companies with multiple insider buys in the last 45 days
0.0%0.0%0.0%

Recent Active Movers

Peer Comparisons

Peers to compare with:

Financials

TCRXGILDBMYIOVACRSPNTLAMedian
NameTScan Th.Gilead S.Bristol-.Iovance .CRISPR T.Intellia. 
Mkt Price1.21133.4856.953.9852.3813.3132.84
Mkt Cap0.2165.6116.11.65.01.53.3
Rev LTM1029,44148,483264168166
Op Inc LTM-13611,69913,591-398-646-441-267
FCF LTM-1409,45611,908-336-426-396-238
FCF 3Y Avg-1069,06112,501-361-301-386-204
CFO LTM-13510,01913,306-302-400-395-219
CFO 3Y Avg-1029,61813,780-339-289-379-196

Growth & Margins

TCRXGILDBMYIOVACRSPNTLAMedian
NameTScan Th.Gilead S.Bristol-.Iovance .CRISPR T.Intellia. 
Rev Chg LTM266.7%2.4%1.8%60.6%-97.1%16.9%9.7%
Rev Chg 3Y Avg78.5%2.6%1.9%--5.0%15.4%2.6%
Rev Chg Q286.0%4.7%2.6%17.7%-78.8%17.7%
QoQ Delta Rev Chg LTM22.6%1.2%0.6%5.2%-17.6%5.2%
Op Inc Chg LTM-0.7%10.4%72.7%-0.7%-36.3%17.5%4.8%
Op Inc Chg 3Y Avg-28.4%3.6%21.0%-0.7%-16.1%0.4%-0.1%
Op Mgn LTM-1,315.4%39.7%28.0%-151.1%-64,639.5%-651.7%-401.4%
Op Mgn 3Y Avg-2,182.4%36.4%20.2%-13,042.3%-22,035.2%-998.4%-1,590.4%
QoQ Delta Op Mgn LTM449.6%1.1%-0.4%13.1%-180.5%13.1%
CFO/Rev LTM-1,310.6%34.0%27.4%-114.8%-39,996.4%-583.3%-349.0%
CFO/Rev 3Y Avg-1,845.8%33.7%29.2%-10,253.5%-13,643.7%-757.5%-1,301.7%
FCF/Rev LTM-1,353.3%32.1%24.6%-127.6%-42,617.6%-585.0%-356.3%
FCF/Rev 3Y Avg-1,910.3%31.8%26.5%-10,884.9%-14,519.9%-774.2%-1,342.3%

Valuation

TCRXGILDBMYIOVACRSPNTLAMedian
NameTScan Th.Gilead S.Bristol-.Iovance .CRISPR T.Intellia. 
Mkt Cap0.2165.6116.11.65.01.53.3
P/S15.25.62.46.25,031.222.810.7
P/Op Inc-1.214.28.5-4.1-7.8-3.5-2.3
P/EBIT-1.215.310.2-4.1-7.8-3.5-2.4
P/E-1.219.516.0-4.1-8.8-3.7-2.5
P/CFO-1.216.58.7-5.4-12.6-3.9-2.5
Total Yield-82.6%7.6%10.6%-24.1%-11.3%-26.7%-17.7%
Dividend Yield0.0%2.4%4.4%0.0%0.0%0.0%0.0%
FCF Yield 3Y Avg-50.1%7.5%10.5%-21.6%-7.6%-27.5%-14.6%
D/E0.60.20.40.00.20.10.2
Net D/E-0.40.10.3-0.2-0.3-0.2-0.2

Returns

TCRXGILDBMYIOVACRSPNTLAMedian
NameTScan Th.Gilead S.Bristol-.Iovance .CRISPR T.Intellia. 
1M Rtn19.8%-4.5%-4.4%16.0%5.8%1.4%3.6%
3M Rtn21.5%-6.3%2.8%50.8%0.7%2.0%2.4%
6M Rtn8.0%9.9%27.7%118.7%-7.1%9.1%9.5%
12M Rtn-19.3%33.3%19.4%13.7%39.2%57.7%26.4%
3Y Rtn-49.6%85.3%-4.0%-41.9%-6.1%-69.7%-24.0%
1M Excs Rtn6.6%-14.5%-13.8%10.8%-3.2%-9.7%-6.5%
3M Excs Rtn16.6%-11.2%-2.2%45.8%-4.2%-2.9%-2.6%
6M Excs Rtn-43.8%6.7%20.2%95.9%-24.3%-0.7%3.0%
12M Excs Rtn-52.0%4.5%-9.4%-13.9%9.3%22.9%-2.4%
3Y Excs Rtn-120.8%5.6%-76.1%-103.5%-67.1%-138.8%-89.8%

Comparison Analyses

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Financials

Segment Financials

Revenue by Segment
$ Mil2025202420232022
Development of T cell receptor (TCR)-engineered T cell (TCR-T) therapies for the treatment of2114101
Total2114101


Price Behavior

Price Behavior
Market Price$1.21 
Market Cap ($ Bil)0.2 
First Trading Date07/16/2021 
Distance from 52W High-52.0% 
   50 Days200 Days
DMA Price$1.11$1.38
DMA Trenddownup
Distance from DMA8.9%-12.5%
 3M1YR
Volatility80.2%88.8%
Downside Capture1.661.81
Upside Capture319.61219.47
Correlation (SPY)44.4%31.6%
TCRX Betas & Captures as of 4/30/2026

 1M2M3M6M1Y3Y
Beta1.941.892.392.452.261.26
Up Beta1.041.092.022.532.491.32
Down Beta31.891.161.251.430.480.98
Up Capture254%324%408%251%389%128%
Bmk +ve Days15223166141428
Stock +ve Days12182450111332
Down Capture-114%194%219%226%193%110%
Bmk -ve Days4183056108321
Stock -ve Days9223363123377

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with TCRX
TCRX-23.4%89.1%0.11-
Sector ETF (XLV)6.8%15.7%0.2324.8%
Equity (SPY)27.8%12.5%1.7331.8%
Gold (GLD)40.6%27.2%1.235.0%
Commodities (DBC)50.1%18.0%2.16-7.3%
Real Estate (VNQ)11.0%13.4%0.5320.8%
Bitcoin (BTCUSD)-17.3%42.2%-0.3425.6%

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Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with TCRX
TCRX-34.0%98.8%0.01-
Sector ETF (XLV)5.2%14.6%0.1812.7%
Equity (SPY)12.8%17.1%0.5914.7%
Gold (GLD)20.2%17.9%0.924.8%
Commodities (DBC)14.0%19.1%0.60-0.1%
Real Estate (VNQ)3.4%18.8%0.0911.5%
Bitcoin (BTCUSD)7.9%56.2%0.357.6%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with TCRX
TCRX-18.8%98.8%0.01-
Sector ETF (XLV)9.2%16.5%0.4512.7%
Equity (SPY)14.9%17.9%0.7114.7%
Gold (GLD)13.4%15.9%0.704.8%
Commodities (DBC)9.6%17.7%0.45-0.1%
Real Estate (VNQ)5.6%20.7%0.2311.5%
Bitcoin (BTCUSD)67.4%66.9%1.067.6%

Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date4152026
Short Interest: Shares Quantity0.9 Mil
Short Interest: % Change Since 3312026-50.0%
Average Daily Volume1.6 Mil
Days-to-Cover Short Interest1
Basic Shares Quantity129.9 Mil
Short % of Basic Shares0.7%

Earnings Returns History

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 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
3/4/20264.3%14.0%-0.5%
11/12/2025-2.5%-18.8%-17.2%
8/12/20253.7%11.2%14.3%
3/5/2025-5.0%-9.9%-37.1%
11/12/2024-4.9%-26.3%-46.0%
8/12/20241.4%-3.0%0.0%
3/6/20241.7%-3.8%0.9%
11/9/2023-0.9%9.4%50.8%
...
SUMMARY STATS   
# Positive755
# Negative81010
Median Positive1.7%9.4%12.1%
Median Negative-3.7%-14.4%-26.0%
Max Positive5.4%14.0%50.8%
Max Negative-21.2%-30.9%-53.7%

SEC Filings

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Report DateFiling DateFiling
12/31/202503/04/202610-K
09/30/202511/12/202510-Q
06/30/202508/12/202510-Q
03/31/202505/06/202510-Q
12/31/202403/05/202510-K
09/30/202411/12/202410-Q
06/30/202408/12/202410-Q
03/31/202405/13/202410-Q
12/31/202303/06/202410-K
09/30/202311/09/202310-Q
06/30/202308/10/202310-Q
03/31/202305/10/202310-Q
12/31/202203/08/202310-K
09/30/202211/09/202210-Q
06/30/202208/10/202210-Q
03/31/202205/12/202210-Q

Recent Forward Guidance [BETA]

Latest: Q4 2025 Earnings Reported 3/4/2026

Forward GuidanceGuidance Change
MetricLowMidHigh% Chg% DeltaChangePrior
2027 Cash Runway      

Prior: Q3 2025 Earnings Reported 11/12/2025

Forward GuidanceGuidance Change
MetricLowMidHigh% Chg% DeltaChangePrior
2027 Cash Runway      

Insider Activity

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#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Lynx1, Capital Management LPSee footnoteBuy122320250.906,2325,6027,208,412Form
2Lynx1, Capital Management LPSee footnoteBuy122320250.9075,50067,9507,211,624Form
3Lynx1, Capital Management LPSee footnoteBuy122320250.9080,06971,9747,134,943Form
4Lynx1, Capital Management LPSee footnoteBuy52120251.201,200,0001,440,0009,535,369Form
5Lynx1, Capital Management LPSee footnoteBuy52120251.201,388,7941,666,5538,095,369Form