Tearsheet

SELLAS Life Sciences (SLS)


Market Price (4/25/2026): $4.61 | Market Cap: $651.2 Mil
Sector: Health Care | Industry: Biotechnology

SELLAS Life Sciences (SLS)


Market Price (4/25/2026): $4.61
Market Cap: $651.2 Mil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0

Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -11%

Megatrend and thematic drivers
Megatrends include Aging Population & Chronic Disease, and Precision Medicine. Themes include Oncology Treatments, Targeted Therapies, Show more.

Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 13.63

Very low revenue
Rev LTMTotal Revenue or Sales, Last Twelve Months is 0

Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -28 Mil

Stock price has recently run up significantly
6M Rtn6 month market price return is 124%, 12M Rtn12 month market price return is 233%

Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -8.4%

Significant short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 40%

Key risks
SLS key risks include [1] a critical dependency on the success of its pivotal Phase 3 REGAL trial for drug candidate GPS and [2] overcoming intense competition in the saturated Acute Myeloid Leukemia market to achieve market adoption.

0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -11%
1 Megatrend and thematic drivers
Megatrends include Aging Population & Chronic Disease, and Precision Medicine. Themes include Oncology Treatments, Targeted Therapies, Show more.
2 Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 13.63
3 Very low revenue
Rev LTMTotal Revenue or Sales, Last Twelve Months is 0
4 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -28 Mil
5 Stock price has recently run up significantly
6M Rtn6 month market price return is 124%, 12M Rtn12 month market price return is 233%
6 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -8.4%
7 Significant short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 40%
8 Key risks
SLS key risks include [1] a critical dependency on the success of its pivotal Phase 3 REGAL trial for drug candidate GPS and [2] overcoming intense competition in the saturated Acute Myeloid Leukemia market to achieve market adoption.

Valuation, Metrics & Events

Price Chart

Why The Stock Moved

Qualitative Assessment

AI Analysis | Feedback

SELLAS Life Sciences (SLS) stock has gained about 20% since 12/31/2025 because of the following key factors:

1. Strengthened Financial Position and Extended Cash Runway.

SELLAS Life Sciences significantly bolstered its financial standing by receiving an additional $42.6 million in proceeds from warrant exercises during the first quarter of 2026, building upon its $71.8 million in cash and cash equivalents as of December 31, 2025. This inflow provided the company with its strongest financial position in history, extending its cash runway.

2. Advancements and Expansion of the SLS009 Clinical Program.

The company announced the enrollment of the first patient in a randomized Phase 2 trial of SLS009 (tambiciclib) for newly diagnosed, first-line Acute Myeloid Leukemia (AML) on March 12, 2026, with topline data anticipated in Q4 2026. Additionally, in January 2026, SELLAS entered a strategic collaboration with IMPACT-AML, a European initiative, to expand the SLS009 clinical program into Europe, with European enrollment expected to commence in Q2 2026.

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Stock Movement Drivers

Fundamental Drivers

The 18.3% change in SLS stock from 12/31/2025 to 4/24/2026 was primarily driven by a 0.0% change in the company's Total Revenues ($ Mil).
(LTM values as of)123120254242026Change
Stock Price ($)3.774.4618.3%
Change Contribution By: 
Total Revenues ($ Mil)000.0%
P/S Multiple0.0%
Shares Outstanding (Mil)108141-23.3%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

12/31/2025 to 4/24/2026
ReturnCorrelation
SLS18.3% 
Market (SPY)4.2%29.2%
Sector (XLV)-6.9%22.6%

Fundamental Drivers

The 177.0% change in SLS stock from 9/30/2025 to 4/24/2026 was primarily driven by a 0.0% change in the company's Total Revenues ($ Mil).
(LTM values as of)93020254242026Change
Stock Price ($)1.614.46177.0%
Change Contribution By: 
Total Revenues ($ Mil)000.0%
P/S Multiple0.0%
Shares Outstanding (Mil)99141-30.2%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

9/30/2025 to 4/24/2026
ReturnCorrelation
SLS177.0% 
Market (SPY)7.0%21.7%
Sector (XLV)4.0%12.8%

Fundamental Drivers

The 313.0% change in SLS stock from 3/31/2025 to 4/24/2026 was primarily driven by a 0.0% change in the company's Total Revenues ($ Mil).
(LTM values as of)33120254242026Change
Stock Price ($)1.084.46313.0%
Change Contribution By: 
Total Revenues ($ Mil)000.0%
P/S Multiple0.0%
Shares Outstanding (Mil)74141-47.6%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

3/31/2025 to 4/24/2026
ReturnCorrelation
SLS313.0% 
Market (SPY)28.1%19.1%
Sector (XLV)0.1%19.2%

Fundamental Drivers

The 211.9% change in SLS stock from 3/31/2023 to 4/24/2026 was primarily driven by a 9.2233720368547763E17% change in the company's P/S Multiple.
(LTM values as of)33120234242026Change
Stock Price ($)1.434.46211.9%
Change Contribution By: 
Total Revenues ($ Mil)10 
P/S Multiple29.79.2233720368547763E17%
Shares Outstanding (Mil)21141-85.3%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

3/31/2023 to 4/24/2026
ReturnCorrelation
SLS211.9% 
Market (SPY)79.8%13.4%
Sector (XLV)16.6%14.6%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
SLS Return-5%-57%-55%-2%262%23%-20%
Peers Return-30%-42%107%-56%10%24%-50%
S&P 500 Return27%-19%24%23%16%4%89%

Monthly Win Rates [3]
SLS Win Rate42%50%50%33%58%50% 
Peers Win Rate27%40%57%40%48%70% 
S&P 500 Win Rate75%42%67%75%67%50% 

Max Drawdowns [4]
SLS Max Drawdown-8%-67%-63%-52%-12%-8% 
Peers Max Drawdown-39%-61%-43%-62%-53%-16% 
S&P 500 Max Drawdown-1%-25%-1%-2%-15%-7% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: KURA, TCRX, AGEN, MRKR, IMMX.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 4/24/2026 (YTD)

How Low Can It Go

Unique KeyEventSLSS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-93.6%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven1458.0%34.1%
2022 Inflation ShockTime to BreakevenTime to BreakevenNot Fully Recovered days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-67.3%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven206.1%51.3%
2020 Covid PandemicTime to BreakevenTime to BreakevenNot Fully Recovered days148 days
2018 Correction2018 Correction  
2018 Correction% Loss% Loss-99.9%-19.8%
2018 Correction% Gain to Breakeven% Gain to Breakeven81826.2%24.7%
2018 CorrectionTime to BreakevenTime to BreakevenNot Fully Recovered days120 days
2008 Global Financial Crisis2008 Global Financial Crisis  
2008 Global Financial Crisis% Loss% Loss-88.4%-56.8%
2008 Global Financial Crisis% Gain to Breakeven% Gain to Breakeven760.8%131.3%
2008 Global Financial CrisisTime to BreakevenTime to BreakevenNot Fully Recovered days1,480 days

Compare to KURA, TCRX, AGEN, MRKR, IMMX

In The Past

SELLAS Life Sciences's stock fell -93.6% during the 2022 Inflation Shock from a high on 6/28/2021. A -93.6% loss requires a 1458.0% gain to breakeven.

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About SELLAS Life Sciences (SLS)

SELLAS Life Sciences Group, Inc., a late-stage biopharmaceutical company, focuses on the development of novel cancer immunotherapies for various cancer indications in the United States. Its lead product candidate is galinpepimut-S (GPS), a cancer immunotherapeutic agent that targets Wilms tumor 1, which is in Phase III clinical trials for the treatment of acute myeloid leukemia; and in Phase 1/2 clinical trials for the treatment for ovarian cancer. The company also develops nelipepimut-S, a cancer immunotherapy that targets human epidermal growth factor receptor 2, which is in Phase 2b clinical trials for the treatment of early-stage breast cancer. It has a strategic collaboration with Merck & Co., Inc. to evaluate GPS as it is administered in combination with PD1 blocker pembrolizumab in a Phase 1/2 clinical trial enrolling patients in up to five cancer indications, including hematologic malignancies and solid tumors. The company was founded in 2012 and is headquartered in New York, New York.

AI Analysis | Feedback

Here are 1-2 brief analogies for SELLAS Life Sciences (SLS):

  • Think of them as a Moderna or BioNTech, but for novel cancer immunotherapies instead of vaccines, still aiming for their big breakthrough.
  • A focused biotech company, similar to a younger Genentech, specializing in developing new cancer immunotherapy drugs.

AI Analysis | Feedback

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  • galinpepimut-S (GPS): A cancer immunotherapeutic agent targeting Wilms tumor 1, in Phase III clinical trials for acute myeloid leukemia and Phase 1/2 for ovarian cancer.
  • nelipepimut-S: A cancer immunotherapy targeting human epidermal growth factor receptor 2, in Phase 2b clinical trials for early-stage breast cancer.
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AI Analysis | Feedback

SELLAS Life Sciences (SLS) is a late-stage biopharmaceutical company primarily focused on the research and development of novel cancer immunotherapies. Its lead product candidates, galinpepimut-S (GPS) and nelipepimut-S, are currently in various phases of clinical trials (Phase III, Phase 1/2, and Phase 2b).

As their product candidates are still in development and have not yet received regulatory approval for commercial sale, SELLAS Life Sciences does not currently have major customers that purchase its therapeutic products. The company's activities are centered on advancing its pipeline through clinical trials.

While SELLAS has a strategic collaboration with Merck & Co., Inc. (NYSE: MRK) for the evaluation of GPS in combination with pembrolizumab, this relationship is a development partnership rather than a customer-vendor arrangement for product sales.

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Dr. Angelos M. Stergiou, President and Chief Executive Officer

Dr. Stergiou is the founder of SELLAS Life Sciences Group, Inc.. Prior to founding SELLAS in 2012, he co-founded Genesis Life Sciences, Ltd. (now Genesis Research), where he served as President and Chief Operating Officer from 2009 to 2011. From 2002 to 2009, he held international positions of increasing responsibility in pharmaceutical and biotechnology companies, including PAION AG, Accentia Biopharmaceuticals, BioVest International, Analytica International, and Anavex Life Sciences. Dr. Stergiou led the Phase 3 development of a therapeutic cancer vaccine, BiovaxID, and holds a patent on the technology.

John T. Burns, Vice President Finance, Corporate Controller and Interim Principal Accounting Officer

John T. Burns serves as the Vice President Finance, Corporate Controller, and Interim Principal Accounting Officer at SELLAS Life Sciences.

Dragan Cicic, Senior Vice President, Clinical Development

Dr. Cicic has 20 years of experience in the biopharmaceutical industry. Before joining SELLAS, he was a Senior Vice President, Clinical Lead, at Klus Pharma, where he led the global clinical development of targeted solid cancer biologicals. He also held senior management positions at Actinium Pharmaceuticals, launching key clinical trials in hematologic malignancies. Dr. Cicic received his medical degree from the University of Belgrade and an MBA from the Wharton School of the University of Pennsylvania.

Stacy Yeung, Vice President, Associate General Counsel, and Head of Compliance

Stacy Yeung has 20 years of relevant experience and was promoted to Vice President, Associate General Counsel, and Head of Compliance as of March 8, 2024, leading the Company's legal and compliance functions.

AI Analysis | Feedback

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Here are the key risks to SELLAS Life Sciences (SLS):

  1. Clinical Trial and Regulatory Approval Risk: As a late-stage biopharmaceutical company, SELLAS Life Sciences' success is heavily dependent on the successful outcome of its ongoing clinical trials and the subsequent receipt of regulatory approvals for its product candidates. The lead candidate, galinpepimut-S (GPS), is in Phase III for acute myeloid leukemia and Phase 1/2 for ovarian cancer, while nelipepimut-S is in Phase 2b for early-stage breast cancer. There is no guarantee that these clinical trials will demonstrate sufficient efficacy and safety, or that regulatory bodies will grant approval, which could significantly jeopardize the company's future prospects.
  2. Pipeline Concentration Risk: The company's future value and viability are substantially tied to the successful development and commercialization of a limited number of product candidates, primarily galinpepimut-S (GPS) and nelipepimut-S. A failure in the development, clinical trials, or regulatory approval process of one or both of these key candidates would have a disproportionately severe negative impact on SELLAS Life Sciences, given the lack of a broad and diversified product pipeline.
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AI Analysis | Feedback

For SELLAS Life Sciences (symbol: SLS), the addressable markets for their main products are as follows:

  • Galinpepimut-S (GPS) for Acute Myeloid Leukemia (AML): The global acute myeloid leukemia treatment market was valued at approximately USD 3.91 billion in 2025. It is projected to grow to USD 9.79 billion by 2034. North America represented approximately 41% of this global market in 2025.
  • Galinpepimut-S (GPS) for Ovarian Cancer: The global ovarian cancer treatment market (specifically for High-Grade vs. Low-Grade Serous Ovarian Cancer) was valued at USD 3.012 billion in 2025 and is expected to grow to USD 5.703 billion by 2034. The United States accounted for nearly USD 1,922 million of this market in 2024.
  • Nelipepimut-S for Early-Stage Breast Cancer: The global breast cancer market was valued at USD 38.41 billion in 2025 and is projected to reach USD 89.91 billion by 2034. North America dominated the breast cancer market in 2024.

AI Analysis | Feedback

SELLAS Life Sciences (SLS) is a late-stage biopharmaceutical company with no current product revenue; therefore, its future revenue growth over the next 2-3 years is primarily dependent on the successful clinical development, regulatory approval, and commercialization of its lead product candidates. Key drivers of future revenue growth for SELLAS Life Sciences include:
  1. Commercialization of Galinpepimut-S (GPS) for Acute Myeloid Leukemia (AML) in the United States: The most significant anticipated driver is the potential U.S. regulatory approval and subsequent commercial launch of galinpepimut-S (GPS). GPS is currently in a pivotal Phase 3 REGAL trial for AML as maintenance therapy following second complete remission. Analysts' forecasts for substantial revenue beginning in 2026, reaching billions in subsequent years, indicate an expectation of successful product launch and sales for GPS.
  2. Advancement and Potential Commercialization of SLS009 in AML: The progression and potential regulatory approval of SLS009, a highly selective CDK9 inhibitor, for AML indications represent another crucial revenue driver. SLS009 has demonstrated positive Phase 2 data in relapsed/refractory AML, and a new randomized Phase 2 trial evaluating it in newly diagnosed, first-line AML patients commenced enrollment in early 2026. Successful outcomes from these trials could lead to accelerated regulatory approvals and market entry within the projected timeframe.
  3. Expansion into New Geographic Markets and Additional Cancer Indications through Strategic Collaborations: SELLAS's strategic partnerships could drive future revenue by expanding the market reach and therapeutic applications of its product candidates. This includes the existing collaboration with Merck & Co. to evaluate GPS in combination with pembrolizumab across various hematologic malignancies and solid tumors, which could lead to expanded indications. Furthermore, the agreement with IMPACT-AML to extend the SLS009 clinical program into Europe aims to broaden patient access and establish a foundation for potential European commercialization.
  4. Achievement of Milestone Payments from Strategic Partnerships: As a clinical-stage company, SELLAS's revenue growth can also be fueled by milestone payments triggered by the successful achievement of clinical development, regulatory, or commercial milestones from its various strategic collaborations. For example, the agreement with 3D Medicines for GPS commercialization in China includes potential future bonuses up to $191.5 million.

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Share Issuance

  • SELLAS completed multiple registered direct offerings in 2024, resulting in approximately $66.3 million in net proceeds through the issuance of common stock, pre-funded warrants, and accompanying warrants.
  • In 2025, the company received a total of approximately $54.6 million in gross proceeds from the immediate exercise of existing warrants.
  • Subsequent to December 31, 2025, SELLAS received approximately $42.6 million in cash proceeds from common stock warrant exercises.

Inbound Investments

  • SELLAS received approximately $42.6 million in cash from common stock warrant exercises after December 31, 2025.
  • The company received approximately $54.6 million in gross proceeds from warrant exercises in September and October 2025.
  • In January 2025, SELLAS closed a $25 million registered direct offering with a single healthcare-focused institutional investor.

Latest Trefis Analyses

TitleDate
0DASHBOARDS 
1SELLAS Life Sciences Earnings Notes12/16/2025
Title
0ARTICLES

Trade Ideas

Select ideas related to SLS.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
PGNY_3312026_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG03312026PGNYProgynyDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
0.0%0.0%0.0%
CNC_3272026_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG03272026CNCCenteneDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
2.3%2.3%-0.6%
OSCR_3272026_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG03272026OSCROscar HealthDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
3.0%3.0%-2.6%
WAT_3202026_Monopoly_xInd_xCD_Getting_Cheaper03202026WATWatersMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
-0.4%-0.4%-3.3%
GILD_3202026_Quality_Momentum_RoomToRun_10%03202026GILDGilead SciencesQualityQ | Momentum | UpsideQuality Stocks with Momentum and Upside
Buying quality stocks with strong momentum but still having room to run
1.6%1.6%-2.2%

Recent Active Movers

Peer Comparisons

Peers to compare with:

Financials

SLSKURATCRXAGENMRKRIMMXMedian
NameSELLAS L.Kura Onc.TScan Th.Agenus Marker T.Immix Bi. 
Mkt Price4.469.261.263.901.409.854.18
Mkt Cap0.60.80.20.10.00.40.3
Rev LTM06710114708
Op Inc LTM-28-304-136-21-8-30-29
FCF LTM-28-71-140-77-15-25-50
FCF 3Y Avg-33-21-106-157-15-17-27
CFO LTM-28-64-135-77-15-24-46
CFO 3Y Avg-32-18-102-153-15-17-25

Growth & Margins

SLSKURATCRXAGENMRKRIMMXMedian
NameSELLAS L.Kura Onc.TScan Th.Agenus Marker T.Immix Bi. 
Rev Chg LTM-25.2%266.7%10.4%99.1%-62.1%
Rev Chg 3Y Avg--78.5%12.0%--45.3%
Rev Chg Q--67.8%286.0%27.5%--27.5%
QoQ Delta Rev Chg LTM--35.1%22.6%6.9%0.0%-3.4%
Op Inc Chg LTM10.3%-57.2%-0.7%83.5%-13.7%-32.1%-7.2%
Op Inc Chg 3Y Avg2.8%-30.7%-28.4%39.0%30.5%-56.3%-12.8%
Op Mgn LTM--449.9%-1,315.4%-18.0%-118.7%--284.3%
Op Mgn 3Y Avg---2,182.4%-80.2%---1,131.3%
QoQ Delta Op Mgn LTM--219.4%449.6%40.9%4.0%-22.5%
CFO/Rev LTM--94.9%-1,310.6%-67.6%-224.8%--159.9%
CFO/Rev 3Y Avg---1,845.8%-121.3%---983.6%
FCF/Rev LTM--104.8%-1,353.3%-67.6%-224.8%--164.8%
FCF/Rev 3Y Avg---1,910.3%-123.7%---1,017.0%

Valuation

SLSKURATCRXAGENMRKRIMMXMedian
NameSELLAS L.Kura Onc.TScan Th.Agenus Marker T.Immix Bi. 
Mkt Cap0.60.80.20.10.00.40.3
P/S-12.115.81.23.6-7.8
P/Op Inc-22.3-2.7-1.2-6.5-3.0-13.2-4.8
P/EBIT-22.3-2.9-1.32.6-3.0-13.2-3.0
P/E-23.5-2.9-1.31,166.1-1.6-13.5-2.3
P/CFO-22.2-12.7-1.2-1.7-1.6-16.6-7.2
Total Yield-4.3%-34.2%-79.3%0.1%-60.9%-7.4%-20.8%
Dividend Yield0.0%0.0%0.0%0.0%0.0%0.0%0.0%
FCF Yield 3Y Avg-52.2%-0.4%-50.1%-132.8%-44.2%-14.5%-47.2%
D/E0.00.00.60.40.00.00.0
Net D/E-0.1-0.8-0.40.4-0.7-0.3-0.3

Returns

SLSKURATCRXAGENMRKRIMMXMedian
NameSELLAS L.Kura Onc.TScan Th.Agenus Marker T.Immix Bi. 
1M Rtn-15.8%8.3%21.2%9.6%4.5%10.5%8.9%
3M Rtn4.7%7.3%10.5%20.4%-33.3%83.1%8.9%
6M Rtn124.1%-4.5%-45.5%-5.8%35.9%172.9%15.7%
12M Rtn232.8%44.0%-26.7%38.3%10.2%462.9%41.2%
3Y Rtn220.9%-13.7%-49.4%-87.9%54.6%413.0%20.4%
1M Excs Rtn-24.5%-0.4%12.5%0.9%-4.2%1.9%0.2%
3M Excs Rtn1.1%3.7%6.9%16.8%-36.9%79.5%5.3%
6M Excs Rtn121.8%-7.2%-50.7%-10.7%34.1%211.8%13.5%
12M Excs Rtn207.2%12.1%-56.0%3.6%-13.6%442.7%7.8%
3Y Excs Rtn113.4%-90.7%-116.7%-161.4%-28.9%365.8%-59.8%

Comparison Analyses

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Financials

Segment Financials

Assets by Segment
$ Mil20252024202320222021
Development of novel therapeutics for a broad range of cancer indications196212646
Total196212646


Price Behavior

Price Behavior
Market Price$4.46 
Market Cap ($ Bil)0.6 
First Trading Date03/12/2008 
Distance from 52W High-25.2% 
   50 Days200 Days
DMA Price$4.80$2.90
DMA Trendupup
Distance from DMA-7.1%54.0%
 3M1YR
Volatility89.7%90.3%
Downside Capture2.370.84
Upside Capture342.06245.77
Correlation (SPY)45.5%19.4%
SLS Betas & Captures as of 3/31/2026

 1M2M3M6M1Y3Y
Beta3.602.821.581.310.770.72
Up Beta9.753.742.310.040.420.62
Down Beta2.282.23-0.361.060.560.39
Up Capture695%606%496%567%385%153%
Bmk +ve Days7162765139424
Stock +ve Days10233371126345
Down Capture237%145%99%28%68%94%
Bmk -ve Days12233358110323
Stock -ve Days12193054113356

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with SLS
SLS234.2%90.3%1.74-
Sector ETF (XLV)7.7%15.8%0.2817.8%
Equity (SPY)34.0%12.6%2.0519.2%
Gold (GLD)42.9%27.2%1.299.5%
Commodities (DBC)46.4%18.0%1.97-15.4%
Real Estate (VNQ)14.2%13.3%0.7416.3%
Bitcoin (BTCUSD)-16.6%42.1%-0.3210.8%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with SLS
SLS-10.1%93.9%0.35-
Sector ETF (XLV)5.1%14.6%0.1718.0%
Equity (SPY)12.7%17.1%0.5820.4%
Gold (GLD)21.2%17.8%0.976.0%
Commodities (DBC)14.5%19.1%0.620.7%
Real Estate (VNQ)3.7%18.8%0.1018.6%
Bitcoin (BTCUSD)7.0%56.3%0.3415.6%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with SLS
SLS-60.4%130.3%-0.12-
Sector ETF (XLV)9.3%16.5%0.468.9%
Equity (SPY)14.9%17.9%0.7110.7%
Gold (GLD)13.9%15.9%0.733.3%
Commodities (DBC)10.1%17.8%0.473.5%
Real Estate (VNQ)5.4%20.7%0.238.6%
Bitcoin (BTCUSD)68.3%66.9%1.077.7%

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Short Interest

Short Interest: As Of Date4152026
Short Interest: Shares Quantity56.6 Mil
Short Interest: % Change Since 33120265.8%
Average Daily Volume4.2 Mil
Days-to-Cover Short Interest13.6 days
Basic Shares Quantity141.3 Mil
Short % of Basic Shares40.1%

Earnings Returns History

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 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
3/19/2026-8.5%-4.8%-4.0%
11/12/2025-2.0%2.0%36.9%
8/12/2025-3.7%5.6%17.4%
3/20/2025-0.8%-4.1%6.6%
11/13/20240.0%-2.4%-31.3%
8/13/20240.8%10.1%11.8%
3/28/20245.9%32.7%19.8%
11/9/2023-0.2%1.2%13.2%
...
SUMMARY STATS   
# Positive687
# Negative131112
Median Positive1.2%7.8%17.4%
Median Negative-8.5%-17.2%-13.5%
Max Positive10.4%49.4%176.0%
Max Negative-53.7%-58.0%-66.7%

SEC Filings

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Report DateFiling DateFiling
12/31/202503/19/202610-K
09/30/202511/12/202510-Q
06/30/202508/12/202510-Q
03/31/202505/13/202510-Q
12/31/202403/20/202510-K
09/30/202411/13/202410-Q
06/30/202408/13/202410-Q
03/31/202405/14/202410-Q
12/31/202303/28/202410-K
09/30/202311/09/202310-Q
06/30/202308/10/202310-Q
03/31/202305/11/202310-Q
12/31/202203/16/202310-K
09/30/202211/14/202210-Q
06/30/202208/11/202210-Q
03/31/202205/12/202210-Q

Recent Forward Guidance [BETA]

Latest: Q4 2025 Earnings Reported 3/19/2026

Forward GuidanceGuidance Change
MetricLowMidHigh% Chg% DeltaChangePrior
Q2 2026 Patient Enrollment 40    

Prior: Q3 2025 Earnings Reported 11/12/2025

Forward GuidanceGuidance Change
MetricLowMidHigh% Chg% DeltaChangePrior
Q1 2026 Trial Enrollment Initiation      
2025 REGAL Trial Final Analysis