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Qualigen Therapeutics (QLGN)


Market Price (11/19/2025): $3.2 | Market Cap: $5.4 Mil
Sector: Health Care | Industry: Biotechnology

Qualigen Therapeutics (QLGN)


Market Price (11/19/2025): $3.2
Market Cap: $5.4 Mil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Which of these 2 stories sounds closer for this stock?

1. Generates cash flow

The stock generated 4% or more of the share price (called cash flow yield), and shows moderate 10-15% or more growth.

2. Riding a trend

Think Tesla during the pandemic of 2020 when EVs were riding a cultural high, or Nvidia in the current AI boom, or even Figma. These companies don’t have enough yield, or, enough growth, or both - however - they are riding a trend. They have momentum. These can be more volatile - they don’t have the floor of strong cash flow


0  Weak multi-year price returns
2Y Excs Rtn is -138%, 3Y Excs Rtn is -163%
Very low revenue
Rev LTMTotal Revenue or Sales, Last Twelve Months is 0
1   Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -6.2 Mil
2   Debt is significant
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is 61%
3   Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -134%
4   High stock price volatility
Vol 12M is 134%
5   Significant short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 23%
0 Weak multi-year price returns
2Y Excs Rtn is -138%, 3Y Excs Rtn is -163%
1 Very low revenue
Rev LTMTotal Revenue or Sales, Last Twelve Months is 0
2 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -6.2 Mil
3 Debt is significant
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is 61%
4 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -134%
5 High stock price volatility
Vol 12M is 134%
6 Significant short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 23%

Market Valuation & Key Metrics

QLGN Stock


Why The Stock Moved


Qualitative Assessment

AI Generated Analysis | Feedback

Here are the key points for the 45.9% stock movement of Qualigen Therapeutics (QLGN) from approximately July 31, 2025, to November 19, 2025: 1. Strategic Transformation to AI/Crypto/Web3 Focus

Qualigen Therapeutics (QLGN) initiated a significant strategic pivot, officially rebranding to AIxCrypto Holdings, Inc. (AIXC) and shifting its core business from a biopharmaceutical company to one focused on Web3, cryptocurrency, and artificial intelligence. This rebranding and strategic direction were approved by stockholders and publicly announced in October and November 2025, respectively.

2. Successful Closing of $41 Million PIPE Financing

In September 2025, Qualigen Therapeutics announced the successful closing of a $41 million private investment in public equity (PIPE) financing. This crucial funding, led by Faraday Future Intelligent Electric Inc., was primarily earmarked to establish and accelerate the company's new crypto business ventures.

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Stock Movement Drivers

Return vs. Risk


Price Returns Compared

 202020212022202320242025Total [1]
Returns
QLGN Return-29%-64%-88%-57%-85%-24%-100%
Peers Return-15%-9%-6%-3%-3%-17%-44%
S&P 500 Return16%27%-19%24%23%13%105%

Monthly Win Rates [3]
QLGN Win Rate42%25%8%25%8%30% 
Peers Win Rate18%15%23%31%22%62% 
S&P 500 Win Rate58%75%42%67%75%70% 

Max Drawdowns [4]
QLGN Max Drawdown-29%-69%-89%-57%-87%-60% 
Peers Max Drawdown-20%-13%-14%-15%-30%-27% 
S&P 500 Max Drawdown-31%-1%-25%-1%-2%-15% 


[1] Cumulative total returns since the beginning of 2020
[2] Peers: VRTX, APM, BBOT, GDTC, HIND.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2025 data is for the year up to 11/18/2025 (YTD)

How Low Can It Go

Unique KeyEventQLGNS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-98.7%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven7590.9%34.1%
2022 Inflation ShockTime to BreakevenTime to BreakevenNot Fully Recovered days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-83.3%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven499.7%51.3%
2020 Covid PandemicTime to BreakevenTime to BreakevenNot Fully Recovered days148 days
2018 Correction2018 Correction  
2018 Correction% Loss% Loss-99.6%-19.8%
2018 Correction% Gain to Breakeven% Gain to Breakeven22932.3%24.7%
2018 CorrectionTime to BreakevenTime to BreakevenNot Fully Recovered days120 days

Compare to VRTX, APM, BBOT, GDTC, HIND


In The Past

Qualigen Therapeutics's stock fell -98.7% during the 2022 Inflation Shock from a high on 2/8/2021. A -98.7% loss requires a 7590.9% gain to breakeven.

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About Qualigen Therapeutics (QLGN)

Better Bets than Qualigen Therapeutics (QLGN)

Trade Ideas

Select past ideas related to QLGN. For more, see Trefis Trade Ideas.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
GDRX_10312025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG10312025GDRXGoodRxDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
-15.4%-15.4%-15.4%
DXCM_10312025_Monopoly_xInd_xCD_Getting_Cheaper10312025DXCMDexComMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
0.5%0.5%-5.8%
ACHC_10242025_Dip_Buyer_ValueBuy10242025ACHCAcadia HealthcareDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
-33.1%-33.1%-33.1%
PBH_10102025_Dip_Buyer_ValueBuy10102025PBHPrestige Consumer HealthcareDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
-3.3%-3.3%-3.3%
REGN_10032025_Dip_Buyer_ValueBuy10032025REGNRegeneron PharmaceuticalsDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
17.4%17.4%-7.0%
Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
GDRX_10312025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG10312025GDRXGoodRxDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
-15.4%-15.4%-15.4%
DXCM_10312025_Monopoly_xInd_xCD_Getting_Cheaper10312025DXCMDexComMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
0.5%0.5%-5.8%
ACHC_10242025_Dip_Buyer_ValueBuy10242025ACHCAcadia HealthcareDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
-33.1%-33.1%-33.1%
PBH_10102025_Dip_Buyer_ValueBuy10102025PBHPrestige Consumer HealthcareDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
-3.3%-3.3%-3.3%
REGN_10032025_Dip_Buyer_ValueBuy10032025REGNRegeneron PharmaceuticalsDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
17.4%17.4%-7.0%

Recent Active Movers

Recent Active Movers

More From Trefis

Peer Comparisons for Qualigen Therapeutics

Financials

QLGNVRTXAPMBBOTGDTCHINDMedian
NameQualigen.Vertex P.Aptorum BridgeBi.CytoMed .Vyome  
Mkt Price3.21435.52-13.48-4.979.22
Mkt Cap0.0111.3----55.7
Rev LTM011,723-0--0
Op Inc LTM-6-92--93---92
FCF LTM-73,337--60---7
FCF 3Y Avg-82,064----1,028
CFO LTM-73,718--60---7
CFO 3Y Avg-82,419----1,205

Growth & Margins

QLGNVRTXAPMBBOTGDTCHINDMedian
NameQualigen.Vertex P.Aptorum BridgeBi.CytoMed .Vyome  
Rev Chg LTM-10.3%----10.3%
Rev Chg 3Y Avg-10.5%----10.5%
Rev Chg Q-11.0%----11.0%
QoQ Delta Rev Chg LTM-2.7%----2.7%
Op Mgn LTM--0.8%-----0.8%
Op Mgn 3Y Avg-26.2%----26.2%
QoQ Delta Op Mgn LTM-1.0%----1.0%
CFO/Rev LTM-31.7%----31.7%
CFO/Rev 3Y Avg-23.1%----23.1%
FCF/Rev LTM-28.5%----28.5%
FCF/Rev 3Y Avg-19.8%----19.8%

Valuation

QLGNVRTXAPMBBOTGDTCHINDMedian
NameQualigen.Vertex P.Aptorum BridgeBi.CytoMed .Vyome  
Mkt Cap0.0111.3----55.7
P/S-9.5----9.5
P/EBIT-0.925.0----12.0
P/E-0.830.3----14.8
P/CFO-0.829.9----14.6
Total Yield-129.2%3.3%-----62.9%
Dividend Yield0.0%0.0%----0.0%
FCF Yield 3Y Avg-300.5%2.3%-----149.1%
D/E0.70.0----0.3
Net D/E0.6-0.0----0.3

Returns

QLGNVRTXAPMBBOTGDTCHINDMedian
NameQualigen.Vertex P.Aptorum BridgeBi.CytoMed .Vyome  
1M Rtn-11.8%4.5%-20.9%--5.9%-0.7%
3M Rtn68.9%11.5%-32.2%--44.9%21.8%
6M Rtn-14.2%-2.6%-----8.4%
12M Rtn-11.8%-6.7%-----9.3%
3Y Rtn-97.0%38.4%-----29.3%
1M Excs Rtn-16.6%5.7%-21.6%--6.6%-0.4%
3M Excs Rtn66.8%7.0%-36.5%--48.2%21.7%
6M Excs Rtn-25.6%-14.0%-----19.8%
12M Excs Rtn-32.2%-21.2%-----26.7%
3Y Excs Rtn-162.7%-22.1%-----92.4%

Financials

Segment Financials

Assets by Segment

$ Mil20242023202220212020
Discovery, development, and commercialization of its products2    
Single Segment 19   
Total219   


Price Behavior

Short Interest

Short Interest: As Of Date10312025
Short Interest: Shares Quantity382,950
Short Interest: % Change Since 10152025146.7%
Average Daily Volume5,571,636
Days-to-Cover Short Interest1
Basic Shares Quantity1,683,881
Short % of Basic Shares22.7%

Earnings Returns History

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 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
8/15/20234.1%0.0%-6.9%
8/16/2022-2.1%-5.6%-22.4%
5/13/20227.6%3.0%11.4%
3/31/2020-2.6%-7.6%21.5%
11/14/2019-14.7%-23.7%-31.7%
8/14/20193.4%19.5%-62.8%
3/29/20191.6%8.8%2.4%
11/9/2018-6.3%-7.2%-24.4%
...
SUMMARY STATS   
# Positive454
# Negative656
Median Positive3.8%3.0%9.2%
Median Negative-2.4%-7.2%-23.4%
Max Positive7.6%19.5%21.5%
Max Negative-14.7%-23.7%-62.8%

SEC Filings

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Report DateFiling DateFiling
6302025814202510-Q 6/30/2025
3312025721202510-Q 3/31/2025
12312024630202510-K 12/31/2024
93020241114202410-Q 9/30/2024
6302024814202410-Q 6/30/2024
3312024702202410-Q 3/31/2024
12312023408202410-K 12/31/2023
93020231114202310-Q 9/30/2023
6302023814202310-Q 6/30/2023
3312023515202310-Q 3/31/2023
12312022502202310-K 12/31/2022
93020221114202210-Q 9/30/2022
6302022815202210-Q 6/30/2022
3312022513202210-Q 3/31/2022
12312021331202210-K 12/31/2021
93020211115202110-Q 9/30/2021

Insider Activity

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