Monte Rosa Therapeutics (GLUE)


Market Price (8/24/2026): $14.4 | Market Cap: $1.5 BilSector: Health Care | Industry: Biotechnology

Monte Rosa Therapeutics (GLUE)


Market Price (8/24/2026): $14.4
Market Cap: $1.5 Bil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0

Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -40%

Megatrend and thematic drivers
Megatrends include Precision Medicine. Themes include Targeted Therapies, and Biopharmaceutical R&D.

Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 10.59, Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 16%

Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -182 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -633%

Stock price has recently run up significantly
12M Rtn12 month market price return is 197%

Weak revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is -84%, Rev Chg QQuarterly Revenue Change % is -61%

Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 72%

Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -84%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -112%

Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -15%

Key risks
GLUE key risks include [1] reliance on its novel molecular glue degrader (MGD) platform which is largely unproven in humans, Show more.

0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -40%
1 Megatrend and thematic drivers
Megatrends include Precision Medicine. Themes include Targeted Therapies, and Biopharmaceutical R&D.
2 Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 10.59, Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 16%
3 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -182 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -633%
4 Stock price has recently run up significantly
12M Rtn12 month market price return is 197%
5 Weak revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is -84%, Rev Chg QQuarterly Revenue Change % is -61%
6 Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 72%
7 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -84%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -112%
8 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -15%
9 Key risks
GLUE key risks include [1] reliance on its novel molecular glue degrader (MGD) platform which is largely unproven in humans, Show more.

GLUE in ETFs

Weight = GLUE's share of each fund

VTI0.00%
ITOT0.00%
IWM0.03%
XBI0.29%
IWO0.07%
IBB0.06%
VTWO0.04%
AVUV0.02%
+7 more covered ETFs

Valuation & Metrics

Price Chart

Why The Stock Moved

Qualitative Assessment

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Updated on 8/21/2026

Monte Rosa Therapeutics (GLUE) stock has lost about 25% since 4/30/2026 because of the following key factors:

1. Monte Rosa Therapeutics experienced a significant stock decline following its fiscal Q1 2026 financial results.

The company reported its fiscal Q1 2026 earnings on May 7, 2026, with an Earnings Per Share (EPS) of -$0.45, missing analysts' consensus estimates of -$0.39 by $0.06. Quarterly revenue also fell significantly short, coming in at $4.21 million against an estimated $10.95 million. This financial underperformance was a core reason for a sharp stock decline, notably a 29.4% gap down on July 31, 2026, when the stock opened at $15.47 after closing at $22.68 on the previous day.

2. Fiscal Q2 2026 results further exacerbated negative investor sentiment due to continued misses and widening losses.

On August 6, 2026, Monte Rosa Therapeutics announced its fiscal Q2 2026 earnings (for the quarter ended June 30, 2026), reporting an EPS of -$0.43, missing consensus estimates of -$0.38 by $0.05. The company's quarterly revenue was $8.97 million, below analysts' expectations of $12.91 million. More concerningly, Q2 2026 revenue declined 61% year-over-year from $23.19 million in Q2 2025, and the net loss widened by 253% from $12.30 million in Q2 2025 to $43.40 million in Q2 2026. This reflected a significant deterioration in financial performance.

Show more
Updated on 8/21/2026

Monte Rosa Therapeutics (GLUE) stock has lost about 25% since 4/30/2026 because of the following key factors:

1. Monte Rosa Therapeutics experienced a significant stock decline following its fiscal Q1 2026 financial results.

The company reported its fiscal Q1 2026 earnings on May 7, 2026, with an Earnings Per Share (EPS) of -$0.45, missing analysts' consensus estimates of -$0.39 by $0.06. Quarterly revenue also fell significantly short, coming in at $4.21 million against an estimated $10.95 million. This financial underperformance was a core reason for a sharp stock decline, notably a 29.4% gap down on July 31, 2026, when the stock opened at $15.47 after closing at $22.68 on the previous day.

2. Fiscal Q2 2026 results further exacerbated negative investor sentiment due to continued misses and widening losses.

On August 6, 2026, Monte Rosa Therapeutics announced its fiscal Q2 2026 earnings (for the quarter ended June 30, 2026), reporting an EPS of -$0.43, missing consensus estimates of -$0.38 by $0.05. The company's quarterly revenue was $8.97 million, below analysts' expectations of $12.91 million. More concerningly, Q2 2026 revenue declined 61% year-over-year from $23.19 million in Q2 2025, and the net loss widened by 253% from $12.30 million in Q2 2025 to $43.40 million in Q2 2026. This reflected a significant deterioration in financial performance.

3. Increased Research and Development (R&D) expenses contributed to expanded operational losses.

As a clinical-stage biopharmaceutical company focused on developing novel molecular glue degraders, Monte Rosa Therapeutics incurred substantial R&D costs. For fiscal Q2 2026, R&D expenses rose to $48.0 million, a notable increase from $30.7 million in fiscal Q2 2025. This rise was primarily driven by accelerated spending on the MRT-8102 program and other ongoing development and discovery initiatives. While necessary for pipeline advancement, these escalating expenditures, coupled with limited collaboration revenue, directly contributed to the widening net losses and increased cash burn, impacting investor confidence in the company's near-term profitability.

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Stock Movement Drivers

Fundamental Drivers

The -25.3% change in GLUE stock from 4/30/2026 to 8/23/2026 was primarily driven by a -76.8% change in the company's Total Revenues ($ Mil).
(LTM values as of)43020268232026Change
Stock Price ($)19.1514.30-25.3%
Change Contribution By: 
Total Revenues ($ Mil)12429-76.8%
P/S Multiple13.250.5281.3%
Shares Outstanding (Mil)86101-15.7%
Cumulative Contribution-25.3%

LTM = Last Twelve Months as of date shown

Market Drivers

4/30/2026 to 8/23/2026
ReturnCorrelation
GLUE-25.3% 
Market (SPY)6.5%10.6%
Sector (XLV)19.6%10.1%

Fundamental Drivers

The -30.3% change in GLUE stock from 1/31/2026 to 8/23/2026 was primarily driven by a -84.2% change in the company's Total Revenues ($ Mil).
(LTM values as of)13120268232026Change
Stock Price ($)20.5214.30-30.3%
Change Contribution By: 
Total Revenues ($ Mil)18229-84.2%
P/S Multiple9.350.5442.4%
Shares Outstanding (Mil)82101-18.8%
Cumulative Contribution-30.3%

LTM = Last Twelve Months as of date shown

Market Drivers

1/31/2026 to 8/23/2026
ReturnCorrelation
GLUE-30.3% 
Market (SPY)11.0%20.2%
Sector (XLV)13.3%15.1%

Fundamental Drivers

The 188.9% change in GLUE stock from 7/31/2025 to 8/23/2026 was primarily driven by a 1881.3% change in the company's P/S Multiple.
(LTM values as of)73120258232026Change
Stock Price ($)4.9514.30188.9%
Change Contribution By: 
Total Revenues ($ Mil)15929-82.0%
P/S Multiple2.550.51881.3%
Shares Outstanding (Mil)82101-19.0%
Cumulative Contribution188.9%

LTM = Last Twelve Months as of date shown

Market Drivers

7/31/2025 to 8/23/2026
ReturnCorrelation
GLUE188.9% 
Market (SPY)22.2%13.5%
Sector (XLV)35.6%10.9%

Fundamental Drivers

The 102.3% change in GLUE stock from 7/31/2023 to 8/23/2026 was primarily driven by a 9.2233720368547763E17% change in the company's Total Revenues ($ Mil).
(LTM values as of)73120238232026Change
Stock Price ($)7.0714.30102.3%
Change Contribution By: 
Total Revenues ($ Mil)0299.2233720368547763E17%
P/S Multiple50.5 
Shares Outstanding (Mil)49101-51.4%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

7/31/2023 to 8/23/2026
ReturnCorrelation
GLUE102.3% 
Market (SPY)73.2%19.6%
Sector (XLV)36.3%17.3%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
GLUE Return-4%-63%-26%23%126%-6%-30%
Peers Return-3%-49%-3%13%2%42%-20%
S&P 500 Return27%-19%24%23%16%12%103%

Monthly Win Rates [3]
GLUE Win Rate71%33%33%50%50%50% 
Peers Win Rate52%43%35%48%55%52% 
S&P 500 Win Rate75%42%67%75%67%50% 

Max Drawdowns [4]
GLUE Max Drawdown--70%-70%-60%-48%-42% 
Peers Max Drawdown-44%-63%-64%-45%-57%-29% 
S&P 500 Max Drawdown-5%-25%-10%-8%-19%-9% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: KYMR, NRIX, ARVN, CCCC, BMY.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 8/21/2026 (YTD)

How Low Can It Go

EventGLUES&P 500
2025 US Tariff Shock
  % Loss-44.2%-18.8%
  % Gain to Breakeven79.2%23.1%
  Time to Breakeven124 days79 days
Summer-Fall 2023 Five Percent Yield Shock
  % Loss-62.7%-9.5%
  % Gain to Breakeven168.0%10.5%
  Time to Breakeven76 days24 days
2023 SVB Regional Banking Crisis
  % Loss-31.3%-6.7%
  % Gain to Breakeven45.5%7.1%
  Time to Breakeven34 days31 days
2022 Inflation Shock & Fed Tightening
  % Loss-69.9%-24.5%
  % Gain to Breakeven231.9%32.4%
  Time to Breakeven1301 days427 days

Compare to KYMR, NRIX, ARVN, CCCC, BMY

In The Past

Monte Rosa Therapeutics's stock fell -44.2% during the 2025 US Tariff Shock. Such a loss loss requires a 79.2% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

EventGLUES&P 500
2025 US Tariff Shock
  % Loss-44.2%-18.8%
  % Gain to Breakeven79.2%23.1%
  Time to Breakeven124 days79 days
Summer-Fall 2023 Five Percent Yield Shock
  % Loss-62.7%-9.5%
  % Gain to Breakeven168.0%10.5%
  Time to Breakeven76 days24 days
2023 SVB Regional Banking Crisis
  % Loss-31.3%-6.7%
  % Gain to Breakeven45.5%7.1%
  Time to Breakeven34 days31 days
2022 Inflation Shock & Fed Tightening
  % Loss-69.9%-24.5%
  % Gain to Breakeven231.9%32.4%
  Time to Breakeven1301 days427 days

Compare to KYMR, NRIX, ARVN, CCCC, BMY

In The Past

Monte Rosa Therapeutics's stock fell -44.2% during the 2025 US Tariff Shock. Such a loss loss requires a 79.2% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About Monte Rosa Therapeutics (GLUE)

Monte Rosa Therapeutics, Inc. (GLUE) is a biopharmaceutical company at the forefront of developing a novel class of precision medicines called "molecular glue degraders." These innovative small molecule drugs are designed to harness the body's natural protein degradation mechanisms to selectively eliminate specific disease-causing proteins. This approach seeks to provide highly targeted and effective treatments across a spectrum of difficult-to-treat diseases.

The company's pipeline includes several key programs. Its lead candidate is an oral molecular glue degrader targeting GSPT1, specifically developed for the treatment of Myc-driven cancers. In oncology, Monte Rosa is also advancing a program for CDK2, aimed at addressing ovarian, uterine, and breast cancers. Beyond cancer, the company is developing NEK7 for inflammatory diseases such as Crohn's disease, neurodegenerative conditions, diabetes, and liver disease.

Monte Rosa Therapeutics further expands its therapeutic focus with programs targeting VAV1 for autoimmune diseases and BCL11A for hemoglobinopathies. By leveraging its molecular glue degrader platform, Monte Rosa aims to serve patients in need of advanced treatments for a wide range of cancers, inflammatory and autoimmune disorders, and genetic blood diseases.

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  • Genentech for targeted protein degradation.
  • Moderna for protein 'clean-up' drugs.

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  • Oral molecular glue degrader for GSPT1: A precision medicine for the treatment of Myc-driven cancers.
  • CDK2: A treatment in development for ovarian, uterine, and breast cancers.
  • NEK7: A therapeutic target for inflammatory diseases, including Crohn's disease, neurodegenerative disease, diabetes, and liver disease.
  • VAV1: A target protein being developed for autoimmune diseases.
  • BCL11A: A therapeutically-relevant protein targeted for hemoglobinopathies.

AI Analysis | Feedback

Monte Rosa Therapeutics, Inc. (GLUE) is a clinical-stage biopharmaceutical company focused on the research and development of novel small molecule precision medicines. As of now, the company does not have any commercialized products on the market.

Therefore, Monte Rosa Therapeutics does not currently have major customers that purchase its products. Its primary activities are advancing its pipeline candidates through preclinical and clinical development.

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Markus Warmuth, M.D., Chief Executive Officer

Dr. Warmuth has served as President and Chief Executive Officer of Monte Rosa Therapeutics since January 2020. He brings over 20 years of experience in drug discovery and precision medicine. Prior to Monte Rosa, he was an Entrepreneur-in-Residence at Third Rock Ventures, where he was involved in forming new biotech companies. He also served as Chief Executive Officer of H3 Biomedicine for seven years, an oncology biopharmaceutical company, leading teams involved in developing Ceritinib and Ribociclib. Dr. Warmuth also held multiple leadership roles at the Novartis Institutes for Biomedical Research (NIBR) and the Genomics Institute of the Novartis Research Foundation (GNF), contributing to the development of Ceritinib and Ribociclib, and the discovery of allosteric SHP2 and Abl inhibitors. He currently serves as a Venture Partner at Versant Ventures.

Ajim Tamboli, CFA, Chief Financial Officer

Mr. Tamboli has served as Chief Financial Officer of Monte Rosa Therapeutics since September 2020. He was instrumental in leading private and public fundraises exceeding $465 million for Monte Rosa, including an upsized $255 million IPO. Before joining Monte Rosa, Mr. Tamboli was CFO at Rodin Therapeutics, where he managed investor fundraising and supported its acquisition by Alkermes for up to $950 million. He also previously served as a founding partner of Endurant Capital Management, a healthcare-dedicated asset management firm, and worked with Columbia Management, focusing on life sciences investing and managing a global portfolio of biotech and pharmaceutical companies. Earlier in his career, he led coverage and executed IPOs and follow-on offerings for numerous biotech and healthcare companies at Lehman Brothers, Credit Suisse, and Lazard Frères.

Sharon Townson, Ph.D., Chief Scientific Officer

Dr. Townson was promoted to Chief Scientific Officer on May 30, 2024, after joining Monte Rosa as Chief Technology Officer. She brings extensive expertise in molecular glues and targeted protein degradation technology platforms. Prior to Monte Rosa, she served as Executive Director of Platform Biology at Kymera Therapeutics. Dr. Townson was also part of the leadership team at Warp Drive Bio, where she was responsible for developing a novel molecular glue approach targeting KRAS. She began her career at Pfizer as a structural biologist.

Jennifer Champoux, Chief Operating Officer

Ms. Champoux was promoted to Chief Operating Officer on May 30, 2024. She previously held the roles of Chief People and Operations Officer since March 2023 and Senior Vice President of Operations from March 2021 to March 2023 at Monte Rosa. Before joining the company, Ms. Champoux was Executive Director of Operations at H3 Biomedicine, leading operations, communications, and finance operations teams. She also led operations for the Discovery Chemistry group at Novartis Institutes for Biomedical Research in Cambridge. Her career began in various pharmaceutical development functions at Merck and Array BioPharma.

Phil Nickson, Ph.D., J.D., Chief Business and Legal Officer

Dr. Nickson was promoted to Chief Business and Legal Officer on May 30, 2024, having joined Monte Rosa in 2021 as General Counsel to support the company's IPO. In his role, he leads Monte Rosa's business development and legal departments. Prior to Monte Rosa, he spent over 10 years with Momenta Pharmaceuticals until its acquisition by Johnson and Johnson in 2020, and then supported the integration of Momenta into J&J for approximately one year.

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Key Risks to Monte Rosa Therapeutics (GLUE)

  1. Clinical Trial Success and Development Risk: As an early-stage biopharmaceutical company, Monte Rosa Therapeutics' business heavily relies on the successful development and clinical validation of its novel small molecule precision medicines. The inherent failure rates in clinical trials are high, and the success of its drug candidates, currently in Phase 1 and progressing to Phase 2, is the primary and highest-impact catalyst for the company. Biopharmaceutical drug development is a highly speculative undertaking with a substantial degree of risk.
  2. Funding, Cash Burn, and Shareholder Dilution Risk: Developing new drugs is an expensive and capital-intensive process. Monte Rosa Therapeutics has a significant cash burn and, as an early-stage biotech, will likely require future financing, which poses a substantial risk of dilution for existing shareholders. Despite a current cash runway expected to last into 2028, recent equity raises have already highlighted concerns about potential dilution. The company has also experienced unstable profits and declining revenue forecasts.
  3. Regulatory Approval and Unproven Technology Risk: Even with successful clinical trials, obtaining regulatory approval (e.g., from the FDA) for its drug candidates is not guaranteed and can be unpredictable, potentially hindering market entry and future opportunities. Furthermore, Monte Rosa's core molecular glue degrader technology, while innovative and promising, is still largely unproven in its broader application and commercialization, introducing an additional layer of uncertainty regarding its long-term viability and competitive standing.

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Monte Rosa Therapeutics (symbol: GLUE) is developing precision medicines targeting various diseases. The addressable markets for their main product candidates are outlined below.
  • Oral molecular glue degrader for GSPT1 (Myc-driven cancers): The global Myc proto-oncogene protein market was valued at USD 1.68 billion in 2024 and is projected to grow to USD 3.06 billion by 2029. The GSPT1 segment of the global molecular glue degrader market was estimated at approximately USD 74.3 million in 2024.
  • CDK2 inhibitor (Ovarian, Uterine, and Breast Cancers):
    • Ovarian Cancer: The global ovarian cancer treatment market size was estimated at USD 3.5 billion in 2023, with projections to reach approximately USD 6.5 billion by 2032. The global ovarian cancer drugs market size was USD 4.09 billion in 2025 and is projected to hit around USD 7.78 billion by 2035.
    • Uterine Cancer: The global uterine cancer treatment market size was approximately USD 23,633.46 million (USD 23.63 billion) in 2024 and is expected to reach nearly USD 39,007.22 million (USD 39.01 billion) by 2033.
    • Breast Cancer: The global breast cancer market size was estimated at USD 26.23 billion in 2025 and is predicted to increase to approximately USD 40.11 billion by 2035.
  • NEK7 inhibitor (Inflammatory Diseases, such as Crohn's disease, Neurodegenerative disease, Diabetes, and Liver disease):
    • Crohn's Disease: The global Crohn's Disease Market was estimated at USD 11.93 billion in 2024 and is projected to grow to USD 17.83 billion by 2035.
    • Neurodegenerative Disease: The global neurodegenerative disease market size is estimated to be valued at USD 55.6 billion in 2025 and is projected to reach USD 109.5 billion by 2035.
    • Diabetes: The global diabetes drugs market size was valued at USD 101.48 billion in 2025 and is projected to grow to USD 283.36 billion by 2034.
    • Liver Disease: A specific addressable market size for "inflammatory liver disease" was not identified in the provided search results.
  • VAV1 (Autoimmune Diseases): The global autoimmune disease therapeutics market is valued at USD 168.6 billion in 2025 and is forecast to reach USD 226.2 billion by 2035.
  • BCL11A (Hemoglobinopathies): The global hemoglobinopathies market size is valued at USD 5.12 billion in 2025 and is predicted to increase to approximately USD 8.87 billion by 2035.

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Here are 3-5 expected drivers of future revenue growth for Monte Rosa Therapeutics (GLUE) over the next 2-3 years:

  1. Milestone Payments from Novartis Collaboration for MRT-6160: Monte Rosa Therapeutics is eligible to receive significant development, regulatory, and sales milestones, potentially up to $2.1 billion, from its collaboration with Novartis for the VAV1-directed molecular glue degrader (MGD) MRT-6160. These payments are expected to begin upon the initiation of Phase 2 studies, which Novartis is anticipated to commence for MRT-6160 in immune-mediated diseases in 2026.
  2. Advancement of MRT-2359 into Phase 2 Studies: The company plans to initiate a Phase 2 study in the third quarter of 2026 for MRT-2359, its GSPT1 degrader, in combination with apalutamide for metastatic castration-resistant prostate cancer (mCRPC). This progression into a later-stage clinical trial, following encouraging Phase 1/2 data, is a key clinical catalyst that could drive future revenue.
  3. Progression of MRT-8102 into Phase 2 Studies: Monte Rosa Therapeutics expects to share data from its GFORCE-1 study of MRT-8102, a NEK7-directed MGD for inflammatory diseases, in the second half of 2026. This is expected to lead to the initiation of the Phase 2 GFORCE-2 study in atherosclerotic cardiovascular disease (ASCVD) in 2026. Positive interim Phase 1 data showing robust activity and reduction in inflammatory markers supports this advancement.
  4. Initiation of New Clinical Programs from the QuEEN™ Discovery Engine: Leveraging its proprietary QuEEN™ AI/ML-powered discovery engine, Monte Rosa Therapeutics anticipates submitting an Investigational New Drug (IND) application in 2026 for a CDK2 and/or cyclin E1-directed MGD. This would introduce a new oncology program into clinical development, expanding the company's pipeline and future revenue potential.

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Share Issuance

  • Monte Rosa Therapeutics completed its Initial Public Offering (IPO) on June 24, 2021, issuing 11,700,000 shares of common stock at $19.00 per share and receiving net proceeds of $203.9 million after deducting underwriting discounts and offering costs.
  • The company terminated its at-the-market (ATM) equity program prospectus on January 7, 2026, after raising $24.2 million through this program.
  • The number of outstanding shares for Monte Rosa Therapeutics increased by 22.34% in the year prior to March 2026.

Inbound Investments

  • Monte Rosa Therapeutics reported collaboration revenue of $12.8 million in Q3 2025, up from $9.2 million a year prior.
  • The company recorded net income of $7.5 million year-to-date in Q3 2025, reflecting collaboration activity, including the completion of a $150.0 million upfront payment under a 2024 Novartis license.
  • In October 2023, Monte Rosa Therapeutics AG, a wholly-owned subsidiary, entered into a strategic collaboration and licensing agreement with F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. (Roche).

Capital Expenditures

  • Monte Rosa Therapeutics, Inc. invested $651,000 in capital expenditures in Q3 2025, a 61.6% decrease from the previous quarter.
  • For the last 12 months (ending around Q3 2025), capital expenditures were -$4.12 million.
  • The company expects its capital expenditures to continue increasing.

Peer Outperformance in Biotechnology

GLUE has outperformed 59% of its 364 Biotechnology peers over 5Y. Biotechnology ranks 10th of 10 industries in Health Care by median 5Y return. The sector’s gains have largely come from elsewhere.
Share of Biotechnology constituents that GLUE has outperformed, by holding period. Peers without a full price history over a given window are excluded from that window.
1Y
89%
of 460 industry peers · 196.7% return
3Y
80%
of 406 industry peers · 123.1% return
5Y
59%
of 364 industry peers · -62.1% return
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Median price return by industry across the Health Care sector, ranked by 5Y. Biotechnology is GLUE's own industry. Use this to see which corners of the sector have carried the returns.
Industry Names 1Y med3Y med5Y med Top 3 by 5Y
Health Care Distributors 7 9.5%82.4%124.2% CAH 394% · MCK 340% · COR 184%
Health Care Services 20 20.6%46.6%7.5% HIMS 337% · RDNT 157% · DGX 80%
Managed Health Care 8 29.7%-3.0%0.6% OSCR 158% · HQY 63% · ELV 14%
Health Care Facilities 24 7.9%-0.8%-16.4% THC 286% · NHC 265% · ENSG 123%
Health Care Equipment 51 -4.5%-4.5%-17.6% POCI 11300% · UFPT 373% · GKOS 260%
Health Care Supplies 12 33.9%-12.1%-26.0% LNTH 297% · HAE 78% · MMSI 29%
Pharmaceuticals 63 4.5%4.1%-38.2% LQDA 2499% · INDV 1253% · ETON 1190%
Health Care Technology 21 -19.9%-53.0%-72.5% SPOK 115% · HSTM -1% · VEEV -23%
Life Sciences Tools & Services 108 -2.5%-28.0%-72.6% SNWV 1782% · MEDP 245% · ELMD 225%
Biotechnology ← 365 7.8%-24.2%-78.3% BRTX 107550% · CELZ 1771% · DNTH 1543%
Median of constituents with a full price history over each window. Top names are unfiltered by size in this render.

Recent Active Movers

Peer Comparisons

Peers to compare with:

Financials

GLUEKYMRNRIXARVNCCCCBMYMedian
NameMonte Ro.Kymera T.Nurix Th.Arvinas C4 Thera.Bristol-. 
Mkt Price14.30119.8026.729.374.0067.0120.51
Mkt Cap1.511.83.00.60.5136.82.2
Rev LTM29105373173549,18771
Op Inc LTM-182-346-361-18-10113,842-141
FCF LTM-32-238-305-209-8511,440-147
FCF 3Y Avg-25-210-212-275-8412,988-147
CFO LTM-24-237-294-207-8512,782-146
CFO 3Y Avg-19-198-202-273-8314,282-141

Growth & Margins

GLUEKYMRNRIXARVNCCCCBMYMedian
NameMonte Ro.Kymera T.Nurix Th.Arvinas C4 Thera.Bristol-. 
Rev Chg LTM-83.9%134.8%-58.4%-15.0%2.3%3.1%-6.4%
Rev Chg 3Y Avg-52.2%-4.8%81.2%34.0%2.9%34.0%
Rev Chg Q-61.3%466.4%-79.5%1,014.7%2.8%5.7%4.2%
QoQ Delta Rev Chg LTM-33.1%104.0%-48.8%254.3%0.5%1.5%1.0%
Op Inc Chg LTM-1,315.7%-11.1%-56.7%84.7%18.3%39.1%3.6%
Op Inc Chg 3Y Avg-403.4%-29.5%-31.3%43.3%10.5%22.3%-9.5%
Op Mgn LTM-633.0%-329.8%-982.4%-5.7%-288.3%28.1%-309.1%
Op Mgn 3Y Avg-1,015.2%-410.5%-510.2%-145.1%-348.6%21.4%-379.5%
QoQ Delta Op Mgn LTM-287.8%360.4%-543.1%278.1%7.4%0.1%3.8%
CFO/Rev LTM-83.8%-225.5%-798.8%-65.4%-242.2%26.0%-154.6%
CFO/Rev 3Y Avg-375.8%-302.2%-398.9%-134.1%-254.1%29.9%-278.2%
FCF/Rev LTM-111.7%-226.6%-828.3%-65.9%-243.7%23.3%-169.1%
FCF/Rev 3Y Avg-424.9%-316.2%-417.9%-135.2%-255.5%27.2%-285.8%

Valuation

GLUEKYMRNRIXARVNCCCCBMYMedian
NameMonte Ro.Kymera T.Nurix Th.Arvinas C4 Thera.Bristol-. 
Mkt Cap1.511.83.00.60.5136.82.2
P/S50.5112.080.71.914.92.832.7
P/Op Inc-8.0-34.0-8.2-33.5-5.29.9-8.1
P/EBIT-8.0-39.3-8.2-33.5-5.210.0-8.1
P/E-9.0-39.3-8.765.3-5.214.7-6.9
P/CFO-60.3-49.7-10.1-2.9-6.210.7-8.1
Total Yield-11.1%-2.5%-11.5%1.5%-19.4%10.5%-6.8%
Dividend Yield0.0%0.0%0.0%0.0%0.0%3.7%0.0%
FCF Yield 3Y Avg-6.8%-5.2%-14.4%-41.5%-41.6%13.5%-10.6%
D/E0.00.00.00.00.10.30.0
Net D/E-0.4-0.1-0.1-0.9-0.40.2-0.3

Returns

GLUEKYMRNRIXARVNCCCCBMYMedian
NameMonte Ro.Kymera T.Nurix Th.Arvinas C4 Thera.Bristol-. 
1M Rtn-37.2%8.3%14.3%16.6%17.6%7.9%11.3%
3M Rtn-24.0%51.9%52.7%3.0%12.4%14.0%13.2%
6M Rtn-24.7%37.1%69.3%-21.9%85.2%12.9%25.0%
12M Rtn196.7%171.7%163.5%27.9%53.3%46.5%108.4%
3Y Rtn123.1%519.1%218.1%-63.5%25.0%25.9%74.5%
1M Excs Rtn-41.5%4.9%9.0%11.7%6.0%5.4%5.7%
3M Excs Rtn-27.3%45.5%49.4%-0.2%10.6%10.7%10.6%
6M Excs Rtn-35.7%26.0%58.3%-33.0%74.1%1.8%13.9%
12M Excs Rtn202.8%162.9%160.4%11.9%33.9%25.5%97.1%
3Y Excs Rtn46.8%447.8%136.5%-135.7%-53.4%-47.6%-0.4%

Comparison Analyses

null

Financials

Segment Financials

Revenue by Segment
$ Mil202520242023
Developing a portfolio of novel and proprietary molecular glue degraders (MGDs)124760
Total124760


Operating Income by Segment
$ Mil20242023
Developing a portfolio of novel and proprietary molecular glue degraders (MGDs)-81-143
Total-81-143


Net Income by Segment
$ Mil202520242023
Developing a portfolio of novel and proprietary molecular glue degraders (MGDs)-39-73-135
Total-39-73-135


Assets by Segment
$ Mil2023202220212020
Developing a portfolio of novel and proprietary molecular glue degraders (MGDs)30434236649
Total30434236649


Price Behavior

Price Behavior
Market Price$14.30 
Market Cap ($ Bil)1.4 
First Trading Date06/24/2021 
Distance from 52W High-43.5% 
   50 Days200 Days
DMA Price$19.80$18.44
DMA Trendupindeterminate
Distance from DMA-27.8%-22.5%
 3M1YR
Volatility81.6%96.7%
Downside Capture67.7755.14
Upside Capture-67.07170.57
Correlation (SPY)6.4%13.4%
GLUE Betas & Captures as of 7/31/2026

 1M2M3M6M1Y3Y
Beta-0.730.160.540.951.041.39
Up Beta1.342.512.381.612.271.32
Down Beta0.470.20-0.040.25-0.530.80
Up Capture-415%-113%-23%46%258%707%
Bmk +ve Days11223567138427
Stock +ve Days8192753119356
Down Capture89%-15%49%120%70%110%
Bmk -ve Days11212859114326
Stock -ve Days14243672131385

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with GLUE
GLUE224.3%96.5%1.61-
Sector ETF (XLV)28.8%16.0%1.399.3%
Equity (SPY)21.1%12.9%1.2212.9%
Gold (GLD)37.5%28.8%1.1011.4%
Commodities (DBC)43.2%20.2%1.66-7.5%
Real Estate (VNQ)12.9%13.8%0.644.1%
Bitcoin (BTCUSD)-31.6%44.1%-0.738.8%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with GLUE
GLUE-16.7%101.2%0.25-
Sector ETF (XLV)7.1%15.1%0.2823.3%
Equity (SPY)12.9%17.2%0.5727.2%
Gold (GLD)20.6%18.6%0.905.5%
Commodities (DBC)10.4%19.6%0.41-2.3%
Real Estate (VNQ)2.3%18.9%0.0223.4%
Bitcoin (BTCUSD)10.4%52.8%0.3817.4%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with GLUE
GLUE-4.3%100.7%0.34-
Sector ETF (XLV)10.7%16.7%0.5223.1%
Equity (SPY)15.2%17.9%0.7226.9%
Gold (GLD)12.7%16.2%0.645.3%
Commodities (DBC)8.0%18.0%0.36-2.1%
Real Estate (VNQ)5.0%20.7%0.2023.0%
Bitcoin (BTCUSD)63.1%66.1%1.0317.3%

Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date7312026
Short Interest: Shares Quantity16.5 Mil
Short Interest: % Change Since 7152026-4.3%
Average Daily Volume1.6 Mil
Days-to-Cover Short Interest10.6 days
Basic Shares Quantity101.5 Mil
Short % of Basic Shares16.2%

Earnings Returns History

Updated 8/17/2026
Expand for More
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
8/6/20260.6%2.2% 
5/7/2026-2.8%-7.0%-19.7%
3/17/2026-2.0%-8.1%11.5%
11/6/20255.7%15.0%45.0%
8/7/2025-2.9%2.0%13.4%
5/8/20259.6%-3.9%30.1%
3/20/20255.4%-18.1%-32.1%
1/10/2025-4.8%-3.8%7.7%
...
SUMMARY STATS   
# Positive10812
# Negative10127
Median Positive5.2%5.4%12.2%
Median Negative-3.4%-5.9%-19.7%
Max Positive9.6%21.8%45.0%
Max Negative-16.0%-18.1%-32.1%
Collapse to Preview
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
8/6/20260.6%2.2% 
5/7/2026-2.8%-7.0%-19.7%
3/17/2026-2.0%-8.1%11.5%
11/6/20255.7%15.0%45.0%
8/7/2025-2.9%2.0%13.4%
5/8/20259.6%-3.9%30.1%
3/20/20255.4%-18.1%-32.1%
1/10/2025-4.8%-3.8%7.7%
11/7/20240.8%-8.7%-0.4%
5/9/2024-1.5%-0.6%-24.3%
3/14/2024-8.4%12.0%8.4%
11/9/2023-10.6%-0.3%17.3%
8/10/2023-1.6%-4.7%-12.1%
5/11/20231.0%-2.4%13.8%
3/16/20237.4%7.2%4.9%
11/10/20225.3%21.8%12.9%
8/11/20225.2%3.6%4.0%
5/11/2022-16.0%-8.8%-17.2%
11/12/20212.3%-13.8%-28.3%
8/12/2021-3.9%0.4%4.1%
SUMMARY STATS   
# Positive10812
# Negative10127
Median Positive5.2%5.4%12.2%
Median Negative-3.4%-5.9%-19.7%
Max Positive9.6%21.8%45.0%
Max Negative-16.0%-18.1%-32.1%

SEC Filings

Expand for More
Report DateFiling DateFiling
06/30/202608/06/202610-Q
03/31/202605/07/202610-Q
12/31/202503/17/202610-K
09/30/202511/06/202510-Q
06/30/202508/07/202510-Q
03/31/202505/08/202510-Q
12/31/202403/20/202510-K
09/30/202411/07/202410-Q
06/30/202408/08/202410-Q
03/31/202405/09/202410-Q
12/31/202303/14/202410-K
09/30/202311/09/202310-Q
06/30/202308/10/202310-Q
03/31/202305/11/202310-Q
12/31/202203/16/202310-K
09/30/202211/10/202210-Q
Collapse to Preview
Report DateFiling DateFiling
06/30/202608/06/202610-Q
03/31/202605/07/202610-Q
12/31/202503/17/202610-K
09/30/202511/06/202510-Q
06/30/202508/07/202510-Q
03/31/202505/08/202510-Q
12/31/202403/20/202510-K
09/30/202411/07/202410-Q
06/30/202408/08/202410-Q
03/31/202405/09/202410-Q
12/31/202303/14/202410-K
09/30/202311/09/202310-Q
06/30/202308/10/202310-Q
03/31/202305/11/202310-Q
12/31/202203/16/202310-K
09/30/202211/10/202210-Q
06/30/202208/11/202210-Q
03/31/202205/11/202210-Q
12/31/202103/29/202210-K
09/30/202111/10/202110-Q
06/30/202108/12/202110-Q
03/31/202106/21/2021S-1/A

Recent Forward Guidance

Updated 8/7/2026

Latest: Q2 2026 Earnings Reported 8/6/2026

Forward GuidanceGuidance Change
MetricLowMidHigh% Chg% DeltaChangePrior
2029 Cash Runway     Affirmed

Prior: Q1 2026 Earnings Reported 5/7/2026

Forward GuidanceGuidance Change
MetricLowMidHigh% Chg% DeltaChangePrior
2029 Cash Runway     AffirmedGuidance: 0 for 2029

Q4 2025 Earnings Reported 3/17/2026

Forward GuidanceGuidance Change
MetricLowMidHigh% Chg% DeltaChangePrior
2029 Cash Runway     RaisedGuidance: 2,028 for 2028

Q3 2025 Earnings Reported 11/6/2025

Forward GuidanceGuidance Change
MetricLowMidHigh% Chg% DeltaChangePrior
2028 Cash Runway 2,028    

Insider Activity

Updated 7/16/2026
Expand for More
#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Champoux, JenniferChief Operating OfficerDirectSell716202623.384,351101,7301,458,284Form
2Townson, SharonChief Scientific OfficerDirectSell707202623.316,000139,8491,581,345Form
3Janku, FilipChief Medical OfficerDirectSell701202624.505,407132,4721,484,994Form
4Janku, FilipChief Medical OfficerDirectSell630202622.956,000137,7001,376,816Form
5Manning, Anthony M DirectSell630202623.1110,000  Form
Collapse to Preview
#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Champoux, JenniferChief Operating OfficerDirectSell716202623.384,351101,7301,458,284Form
2Townson, SharonChief Scientific OfficerDirectSell707202623.316,000139,8491,581,345Form
3Janku, FilipChief Medical OfficerDirectSell701202624.505,407132,4721,484,994Form
4Janku, FilipChief Medical OfficerDirectSell630202622.956,000137,7001,376,816Form
5Manning, Anthony M DirectSell630202623.1110,000  Form
6Janku, FilipChief Medical OfficerDirectSell625202621.4230,000642,6811,285,191Form
7Janku, FilipChief Medical OfficerDirectSell625202620.2211,845239,5221,213,122Form
8Champoux, JenniferChief Operating OfficerDirectSell625202620.002,17543,5001,247,420Form
9Townson, SharonChief Scientific OfficerDirectSell625202620.003,00060,0001,356,900Form
10Champoux, JenniferChief Operating OfficerDirectSell618202619.002,17641,3441,185,049Form
11Townson, SharonChief Scientific OfficerDirectSell618202619.003,00057,0001,289,055Form
12Warmuth, MarkusPresident & CEODirectSell602202619.445,466106,25311,557,166Form
13Townson, SharonChief Scientific OfficerDirectSell601202619.876,000119,2201,348,080Form
14Champoux, JenniferChief Operating OfficerDirectSell528202620.002,17543,5001,247,420Form
15Champoux, JenniferChief Operating OfficerDirectSell526202619.002,17641,3441,185,049Form
16Manning, Anthony M DirectSell522202618.0110,000  Form
17Warmuth, MarkusPresident & CEODirectSell505202618.925,467103,44711,353,276Form
18Warmuth, MarkusPresident & CEODirectSell415202617.648,000141,12510,680,872Form
19Nickson, PhilipChief Business & Legal OfficerDirectSell410202617.695,845103,413973,088Form
20Warmuth, MarkusPresident & CEODirectSell304202617.925,46697,97410,996,038Form
21Dunn, EdmundPrincipal Accounting OfficerDirectSell302202617.505369,380397,128Form
22Dunn, EdmundPrincipal Accounting OfficerDirectSell302202618.1025,164455,506410,777Form
23Janku, FilipChief Medical OfficerDirectSell224202619.509,189179,1611,283,644Form
24Warmuth, MarkusPresident & CEODirectSell109202623.495,466128,37314,536,138Form
25Nickson, PhilipChief Business & Legal OfficerDirectSell105202615.173,15547,861923,019Form
26Champoux, JenniferChief Operating OfficerDirectSell105202615.172,62939,882946,168Form
27Dunn, EdmundPrincipal Accounting OfficerDirectSell105202615.171,03915,762344,253Form
28Warmuth, MarkusPresident & CEODirectSell105202615.1710,135153,7489,472,194Form
29Janku, FilipChief Medical OfficerDirectSell105202615.173,15547,8611,138,144Form
30Townson, SharonChief Scientific OfficerDirectSell105202615.173,15547,8611,029,209Form

Investor Activity (13F)

Updated Aug 24, 2026
13F holdings as of Mar 31, 2026 (Q1 2026)

Active managers (13F portfolio over $250M, at least 3 holdings) with a position over $5M that is either over 10% of their portfolio or held in a concentrated book of 50 or fewer total positions. Index/ETF, sovereign, bank, community-bank and charitable/donor-advised filers are excluded.

Active ManagerValue% of PortfolioTotal PositionsQoQFiling
NEA Management Company, LLC$126.5 Mil7.2%26Hold13F
Aisling Capital Management LP$25.6 Mil5.4%13ADD +5.7%13F
BVF Inc/Il$73.4 Mil2.3%41ADD +16.3%13F
TCG Crossover Management, LLC$76.0 Mil2.2%49Hold13F
MPM Bioimpact LLC$19.4 Mil1.5%41Hold13F
Frazier Life Sciences Management, L.P.$16.4 Mil0.4%38New13F
Nextech Invest, Ltd.$5.0 Mil0.4%17ADD +9.0%13F
Cormorant Asset Management, LP$6.6 Mil0.3%46New13F
Alphabet Inc.$11.3 Mil0.3%27TRIM -8.1%13F
Active ManagerValue% of PortfolioTotal PositionsQoQFiling
Frazier Life Sciences Management, L.P.$16.4 Mil0.4%38New13F
Cormorant Asset Management, LP$6.6 Mil0.3%46New13F
BVF Inc/Il$73.4 Mil2.3%41ADD +16.3%13F
Nextech Invest, Ltd.$5.0 Mil0.4%17ADD +9.0%13F
Aisling Capital Management LP$25.6 Mil5.4%13ADD +5.7%13F
Active ManagerValue% of PortfolioTotal PositionsQoQFiling
Alphabet Inc.$11.3 Mil0.3%27TRIM -8.1%13F
Active ManagerValue% of PortfolioTotal PositionsQoQFiling
NEA Management Company, LLC$126.5 Mil7.2%26Hold13F
TCG Crossover Management, LLC$76.0 Mil2.2%49Hold13F
BVF Inc/Il$73.4 Mil2.3%41ADD +16.3%13F
Aisling Capital Management LP$25.6 Mil5.4%13ADD +5.7%13F
MPM Bioimpact LLC$19.4 Mil1.5%41Hold13F
Frazier Life Sciences Management, L.P.$16.4 Mil0.4%38New13F
Alphabet Inc.$11.3 Mil0.3%27TRIM -8.1%13F
Cormorant Asset Management, LP$6.6 Mil0.3%46New13F
Nextech Invest, Ltd.$5.0 Mil0.4%17ADD +9.0%13F
Core Cache Last Updated: 8/23/2026