Fennec Pharmaceuticals (FENC)


Market Price (10/9/2026): $10.62 | Market Cap: $366.9 MilSector: Health Care | Industry: Biotechnology

Fennec Pharmaceuticals (FENC)


Market Price (10/9/2026): $10.62
Market Cap: $366.9 Mil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0

Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -11%

Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 78%

Megatrend and thematic drivers
Megatrends include Aging Population & Chronic Disease, and Precision Medicine. Themes include Oncology Treatments, and Biopharmaceutical R&D.

Weak multi-year price returns
3Y Excs Rtn is -32%

Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -1.2 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -2.0%

Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 13%

Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -3.4%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -3.4%

Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -6.2%

Key risks
FENC key risks include [1] significant financial distress and potential bankruptcy risk, Show more.

0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -11%
1 Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 78%
2 Megatrend and thematic drivers
Megatrends include Aging Population & Chronic Disease, and Precision Medicine. Themes include Oncology Treatments, and Biopharmaceutical R&D.
3 Weak multi-year price returns
3Y Excs Rtn is -32%
4 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -1.2 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -2.0%
5 Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 13%
6 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -3.4%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -3.4%
7 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -6.2%
8 Key risks
FENC key risks include [1] significant financial distress and potential bankruptcy risk, Show more.

FENC in ETFs

Weight = FENC's share of each fund

VTI0.00%
IWO0.02%
VTWO0.01%

Valuation & Metrics

Price Chart

Why The Stock Moved

Qualitative Assessment

AI Analysis | Feedback

Updated on 10/1/2026

Fennec Pharmaceuticals (FENC) stock has remained largely at the same level since 6/30/2026 because of the following key factors:

1. Shift in Analyst Outlook on Future Profitability: Analysts revised their view during the period, moving from focusing on long-term concentration and pricing risks to more immediate concerns that heavier operating spend in fiscal year 2026 could outpace revenue growth from PEDMARK® and limit earnings and margin progress.

2. Delayed Breakeven Projections: The consensus forecast for Fennec Pharmaceuticals to achieve profitability was pushed back from fiscal year 2025 to fiscal year 2026. This revision indicates a longer timeline to financial self-sufficiency than previously anticipated.

Show more
Updated on 10/1/2026

Fennec Pharmaceuticals (FENC) stock has remained largely at the same level since 6/30/2026 because of the following key factors:

1. Shift in Analyst Outlook on Future Profitability: Analysts revised their view during the period, moving from focusing on long-term concentration and pricing risks to more immediate concerns that heavier operating spend in fiscal year 2026 could outpace revenue growth from PEDMARK® and limit earnings and margin progress.

2. Delayed Breakeven Projections: The consensus forecast for Fennec Pharmaceuticals to achieve profitability was pushed back from fiscal year 2025 to fiscal year 2026. This revision indicates a longer timeline to financial self-sufficiency than previously anticipated.

3. Concerns over PEDMARK® Revenue Growth and Plateau Risk: Analyst narratives highlighted a "plateau risk" for PEDMARK® revenue, suggesting that the growth of the company's primary commercial product might not be sufficient to offset the anticipated heavier operating expenses in fiscal year 2026. This implies doubts about the product's ability to drive the aggressive top-line expansion needed for profitability.

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Stock Movement Drivers

Fundamental Drivers

The -1.1% change in FENC stock from 6/30/2026 to 10/8/2026 was primarily driven by a -14.3% change in the company's P/S Multiple.
(LTM values as of)630202610082026Change
Stock Price ($)10.7510.63-1.1%
Change Contribution By: 
Total Revenues ($ Mil)515916.1%
P/S Multiple7.26.2-14.3%
Shares Outstanding (Mil)3435-0.6%
Cumulative Contribution-1.1%

LTM = Last Twelve Months as of date shown

Market Drivers

6/30/2026 to 10/8/2026
ReturnCorrelation
FENC-1.1% 
Market (SPY)3.6%21.8%
Sector (XLV)6.0%6.9%

Fundamental Drivers

The 72.8% change in FENC stock from 3/31/2026 to 10/8/2026 was primarily driven by a 44.4% change in the company's P/S Multiple.
(LTM values as of)331202610082026Change
Stock Price ($)6.1510.6372.8%
Change Contribution By: 
Total Revenues ($ Mil)455932.7%
P/S Multiple4.36.244.4%
Shares Outstanding (Mil)3135-9.8%
Cumulative Contribution72.8%

LTM = Last Twelve Months as of date shown

Market Drivers

3/31/2026 to 10/8/2026
ReturnCorrelation
FENC72.8% 
Market (SPY)19.3%23.6%
Sector (XLV)15.2%11.2%

Fundamental Drivers

The 13.6% change in FENC stock from 9/30/2025 to 10/8/2026 was primarily driven by a 77.8% change in the company's Total Revenues ($ Mil).
(LTM values as of)930202510082026Change
Stock Price ($)9.3610.6313.6%
Change Contribution By: 
Total Revenues ($ Mil)335977.8%
P/S Multiple7.86.2-20.3%
Shares Outstanding (Mil)2835-19.9%
Cumulative Contribution13.6%

LTM = Last Twelve Months as of date shown

Market Drivers

9/30/2025 to 10/8/2026
ReturnCorrelation
FENC13.6% 
Market (SPY)17.1%25.9%
Sector (XLV)22.4%20.4%

Fundamental Drivers

The 41.5% change in FENC stock from 9/30/2023 to 10/8/2026 was primarily driven by a 805.9% change in the company's Total Revenues ($ Mil).
(LTM values as of)930202310082026Change
Stock Price ($)7.5110.6341.5%
Change Contribution By: 
Total Revenues ($ Mil)759805.9%
P/S Multiple30.46.2-79.6%
Shares Outstanding (Mil)2635-23.4%
Cumulative Contribution41.5%

LTM = Last Twelve Months as of date shown

Market Drivers

9/30/2023 to 10/8/2026
ReturnCorrelation
FENC41.5% 
Market (SPY)87.3%25.1%
Sector (XLV)36.8%22.5%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
FENC Return-41%118%17%-44%22%35%39%
Peers Return-36%-56%-39%-24%-8%137%-72%
S&P 500 Return27%-19%24%23%16%14%108%

Monthly Win Rates [3]
FENC Win Rate50%75%42%33%50%50% 
Peers Win Rate40%37%37%43%53%46% 
S&P 500 Win Rate75%42%67%75%67%50% 

Max Drawdowns [4]
FENC Max Drawdown-61%-18%-37%-64%-29%-36% 
Peers Max Drawdown-72%-79%-75%-74%-69%-65% 
S&P 500 Max Drawdown-5%-25%-10%-8%-19%-9% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: BYSI, GTBP, AGEN, VSTM, KPTI.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 10/8/2026 (YTD)

How Low Can It Go

EventFENCS&P 500
2025 US Tariff Shock
  % Loss-24.5%-18.8%
  % Gain to Breakeven32.5%23.1%
  Time to Breakeven38 days79 days
2024 Yen Carry Trade Unwind
  % Loss-11.2%-7.8%
  % Gain to Breakeven12.6%8.5%
  Time to Breakeven104 days18 days
Summer-Fall 2023 Five Percent Yield Shock
  % Loss-20.4%-9.5%
  % Gain to Breakeven25.6%10.5%
  Time to Breakeven33 days24 days
2023 SVB Regional Banking Crisis
  % Loss-25.2%-6.7%
  % Gain to Breakeven33.7%7.1%
  Time to Breakeven26 days31 days
2020 COVID-19 Crash
  % Loss-39.0%-33.7%
  % Gain to Breakeven63.9%50.9%
  Time to Breakeven79 days140 days
Q4 2018 Fed Policy Error / Growth Scare
  % Loss-36.0%-19.2%
  % Gain to Breakeven56.2%23.8%
  Time to Breakeven541 days105 days

Compare to BYSI, GTBP, AGEN, VSTM, KPTI

In The Past

Fennec Pharmaceuticals's stock fell -24.5% during the 2025 US Tariff Shock. Such a loss loss requires a 32.5% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

EventFENCS&P 500
2025 US Tariff Shock
  % Loss-24.5%-18.8%
  % Gain to Breakeven32.5%23.1%
  Time to Breakeven38 days79 days
Summer-Fall 2023 Five Percent Yield Shock
  % Loss-20.4%-9.5%
  % Gain to Breakeven25.6%10.5%
  Time to Breakeven33 days24 days
2023 SVB Regional Banking Crisis
  % Loss-25.2%-6.7%
  % Gain to Breakeven33.7%7.1%
  Time to Breakeven26 days31 days
2020 COVID-19 Crash
  % Loss-39.0%-33.7%
  % Gain to Breakeven63.9%50.9%
  Time to Breakeven79 days140 days
Q4 2018 Fed Policy Error / Growth Scare
  % Loss-36.0%-19.2%
  % Gain to Breakeven56.2%23.8%
  Time to Breakeven541 days105 days
2013 Taper Tantrum
  % Loss-66.6%-0.2%
  % Gain to Breakeven199.6%0.2%
  Time to Breakeven190 days1 days
2010 Eurozone Sovereign Debt Crisis / Flash Crash
  % Loss-41.2%-15.4%
  % Gain to Breakeven70.2%18.2%
  Time to Breakeven151 days125 days
2008-2009 Global Financial Crisis
  % Loss-96.0%-53.4%
  % Gain to Breakeven2422.4%114.4%
  Time to Breakeven926 days1085 days
Summer 2007 Credit Crunch
  % Loss-50.0%-8.6%
  % Gain to Breakeven100.0%9.5%
  Time to Breakeven1493 days47 days

Compare to BYSI, GTBP, AGEN, VSTM, KPTI

In The Past

Fennec Pharmaceuticals's stock fell -24.5% during the 2025 US Tariff Shock. Such a loss loss requires a 32.5% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About Fennec Pharmaceuticals (FENC)

Fennec Pharmaceuticals Inc. (FENC) is a biopharmaceutical company dedicated to developing innovative product candidates for the treatment of cancer-related issues in the United States. The company's primary focus is on addressing severe side effects associated with existing cancer therapies, aiming to improve the overall treatment experience and long-term health outcomes for patients.

The flagship product for Fennec Pharmaceuticals is PEDMARK, a proprietary formulation of Sodium Thiosulfate. PEDMARK has successfully completed Phase III clinical trials and is specifically designed for the prevention of cisplatin-induced hearing loss, or ototoxicity, in children. Its main customers are pediatric oncology centers and patients undergoing cisplatin chemotherapy, targeting a crucial unmet need in the care of young cancer patients by mitigating a common and debilitating side effect of their life-saving treatments.

AI Analysis | Feedback

Here are a few analogies to describe Fennec Pharmaceuticals (FENC):

  • A specialized biotech company, much like a smaller BioMarin Pharmaceutical, but focused on preventing hearing loss in children undergoing cancer treatment.
  • Think of them as the Vertex Pharmaceuticals for preventing a specific, devastating side effect (hearing loss) in children undergoing chemotherapy.

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  • PEDMARK: A formulation of Sodium Thiosulfate developed for the prevention of cisplatin-induced hearing loss (ototoxicity) in children.

AI Analysis | Feedback

Fennec Pharmaceuticals Inc. (FENC) is a biopharmaceutical company that develops and commercializes prescription drugs. As such, it does not sell directly to individual consumers. Its major customers are typically other companies involved in the pharmaceutical supply chain, which then distribute the drug to healthcare providers and patients.

Based on the standard distribution model for biopharmaceutical companies, Fennec Pharmaceuticals' major customers would likely include:

  • Pharmaceutical Wholesalers/Distributors: These companies purchase drugs in bulk from manufacturers and then distribute them to hospitals, clinics, and pharmacies. Key players in this sector that could be Fennec's customers include:
    • McKesson Corporation (MCK)
    • AmerisourceBergen Corporation (ABC)
    • Cardinal Health, Inc. (CAH)
  • Large Hospital Systems and Specialty Pharmacies: While often supplied through wholesalers, very large health systems (especially those with significant pediatric oncology departments) or specialized pediatric hospitals, and specialty pharmacies, might have direct purchasing agreements or be significant customers through the distribution channels due to the specific nature of PEDMARK's use.

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  • Hovione Sociedade Gestora, S.A.
  • IDT Biologika GmbH

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Jeffrey S. Hackman, Chief Executive Officer

Jeffrey S. Hackman was appointed Chief Executive Officer in August 2024. He previously served as a director of Fennec Pharmaceuticals. His background includes significant leadership experience in the biopharmaceutical industry.

Robert J. Andrade, Chief Financial Officer

Robert J. Andrade has served as Chief Financial Officer since November 2015. He previously held the CFO and Director role at Fennec from September 2009 to August 2013. In 2015, Mr. Andrade worked as a private investor, and from 2013 to 2014, he was a senior analyst at Magnetar Capital. He earned a Master of Arts degree and a Bachelor of Arts degree in economics from the University of Southern California.

Pierre S. Sayad, PhD, M.S., Chief Medical Officer

Dr. Pierre Sayad was appointed Chief Medical Officer on October 28, 2024. He is an accomplished biopharmaceutical executive with over 22 years of experience, having successfully launched nine novel drugs across 14 therapeutic areas, including oncology and neuroscience. Prior to joining Fennec, he served as chief operating officer and interim chief medical officer at Zephyr Labz. He is a graduate of the School of Medicine, Loma Linda University, and Harvard Business School.

Terry Evans, Chief Commercial Officer

Terry Evans was appointed Chief Commercial Officer on October 28, 2024. He is a seasoned commercial and operations leader known for driving significant revenue growth and leading high-performing teams, with extensive experience across all aspects of commercial operations. Before his appointment at Fennec, Mr. Evans was the chief executive officer of UNITE Pharma Trade Advisors.

Christiana Cioffi, MBA, Chief Strategy Officer

Christiana Cioffi was appointed Chief Strategy Officer on October 28, 2024. She is a seasoned biopharmaceutical industry executive with proven clinical, commercial, operational, and oncology market expertise.

AI Analysis | Feedback

The key risks to Fennec Pharmaceuticals (FENC) primarily revolve around its strong reliance on its sole commercial product, PEDMARK, and the associated challenges in its market adoption and defense. Here are the key risks: 1.

Single Product Dependence

Fennec Pharmaceuticals' business is almost entirely centered on the success of PEDMARK (sodium thiosulfate injection), which is indicated to reduce the risk of ototoxicity associated with cisplatin treatment in pediatric cancer patients. The company's value proposition is "inextricably linked" to the successful commercialization and market defense of this single asset. Any significant setback related to PEDMARK, such as slower-than-expected market adoption, manufacturing issues, or unexpected post-market safety concerns, could have a devastating impact on the company's valuation and financial health. 2.

Commercialization and Market Penetration Challenges

Despite PEDMARK being the first and only FDA-approved therapy for its specific indication, Fennec faces substantial risks in executing its commercialization strategy and achieving widespread market penetration. The company must successfully convince oncologists to adopt PEDMARK as a standard of care and navigate complex reimbursement landscapes with payers. Analysts acknowledge an "implicit execution risk" as the investment case heavily leans on the commercial success of this single product, with any slowdown in uptake potentially weighing on the valuation. 3.

Competitive and Patent Landscape Risk

While PEDMARK currently holds a temporary monopoly due to its Orphan Drug Exclusivity in the U.S. (providing market protection) and its unique approval status, the competitive landscape presents an ongoing risk. Although Fennec recently settled patent litigation with Cipla, delaying generic entry until September 1, 2033, or earlier under specific circumstances, the potential for future generic competition or challenges to its patent protection remains a concern. The risk of patents being challenged, invalidated, or circumvented by competitors is explicitly listed in the company's forward-looking statements.

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The addressable markets for Fennec Pharmaceuticals' main product, PEDMARK (known as PEDMARQSI in some regions outside the U.S.), are as follows:

  • United States: The addressable market in the U.S. includes approximately 2,157 estimated cisplatin-treated pediatric patients annually who are eligible for PEDMARK. An analyst estimated the peak U.S. sales potential for PEDMARK to be over $300 million.
  • Europe: The addressable market in Europe includes approximately 1,250 estimated cisplatin-treated pediatric patients annually who are eligible for PEDMARQSI.
  • Global Drug-Induced Ototoxicity Treatment Market: A broader global market for drug-induced ototoxicity treatment, which includes PEDMARK, was estimated at approximately $1.2 billion in 2023 and is projected to reach about $2.5 billion by 2032. North America holds the largest share of this market, estimated at around $450 million in 2023, and is expected to reach approximately $900 million by 2032.

AI Analysis | Feedback

Fennec Pharmaceuticals (FENC) is poised for future revenue growth over the next 2-3 years, primarily driven by the continued commercialization and market expansion of its lead product, PEDMARK (sodium thiosulfate). Here are the key drivers of future revenue growth: * **Increased Adoption and Market Penetration of PEDMARK in Pediatric Patients (U.S.).** Fennec Pharmaceuticals is focused on expanding the use of PEDMARK, the first and only FDA-approved therapy to reduce cisplatin-induced ototoxicity in pediatric cancer patients, within key accounts across academic and community providers in the United States. The company's refined, targeted sales strategy and enhanced patient support services, including the Fennec HEARS™ program, are designed to facilitate broader institutional adoption and sustained growth. The company reported a 33% increase in net product sales year-over-year and 10% sequential growth in the second quarter of 2025, signaling strong commercial momentum. * **Expansion into Adolescent and Young Adult (AYA) and Adult Patient Populations (U.S.).** Beyond its current pediatric indication, Fennec is actively pursuing the expansion of PEDMARK's use into adolescent and young adult (AYA) and adult cancer patient populations. The National Comprehensive Cancer Network (NCCN) already recommends PEDMARK for AYA patients, and the company is generating clinical evidence, including investigator-initiated studies and real-world data, to support its utility in a broader range of patient demographics, such as those receiving metastatic tumor treatments and adults with head and neck cancers. * **International Commercialization of PEDMARQSI in Europe, Australia, and New Zealand.** Fennec Pharmaceuticals has established an exclusive licensing agreement with Norgine Pharmaceuticals Ltd. for the commercialization of PEDMARQSI (the European brand name for sodium thiosulfate injection) in Europe, Australia, and New Zealand. This partnership includes an upfront payment, potential commercial and regulatory milestone payments of up to approximately $230 million, and double-digit tiered royalties on net sales. PEDMARQSI has already launched commercially in Germany and the United Kingdom, indicating the initiation of international revenue streams. * **Protection of Market Exclusivity for PEDMARK.** Fennec Pharmaceuticals has successfully settled a patent litigation case with Cipla Limited, which sought to market a generic version of PEDMARK. Under the settlement terms, Cipla is restricted from entering the market with its generic product until September 1, 2033, or potentially earlier under specific circumstances. This agreement, combined with Fennec's existing patents providing protection for PEDMARK until 2039 in the U.S. and internationally, ensures crucial market exclusivity and provides a stable revenue generation period without direct generic competition.

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Share Repurchases

  • Fennec Pharmaceuticals utilized proceeds from a November 2025 public offering and concurrent private placement to repurchase and redeem all outstanding convertible notes held by Petrichor Opportunities Fund I LP and Petrichor Opportunities Fund I Intermediate LP.
  • The aggregate repurchase and redemption price for these notes was approximately $21.73 million, which covered outstanding principal, accrued interest, and a redemption fee.
  • This transaction, completed in November 2025, resulted in Fennec Pharmaceuticals having no outstanding debt on its balance sheet.

Share Issuance

  • In November 2025, Fennec Pharmaceuticals completed an underwritten registered public offering in the United States, selling 5,366,667 common shares (including the full exercise of the underwriters' option) at a price of $7.50 per share, generating approximately $40.25 million in total gross proceeds.
  • Concurrently, in November 2025, the company engaged in a non-brokered private offering of its common shares in Canada to existing institutional shareholders, with aggregate gross proceeds of up to US$5.025 million.

Inbound Investments

  • In March 2024, Fennec Pharmaceuticals entered into an exclusive licensing agreement with Norgine Pharmaceuticals Ltd. for the commercialization of PEDMARQSI® in Europe, the U.K., Australia, and New Zealand.
  • Licensing revenue from the Norgine deal contributed $17,958 to Fennec Pharmaceuticals' total net revenue of $39,613 in the third quarter of 2024.

Capital Expenditures

  • Fennec Pharmaceuticals reported a Capital Expenditure Compound Annual Growth Rate (CAGR) of null over the last 5 years, indicating minimal to no significant capital expenditures during this period.
  • The company's latest trailing twelve months (TTM) CapEx CAGR 5YRS stands at 0%.
  • Development costs, including drug substance costs, clinical study expenses, and regulatory expenses, are expensed as incurred rather than capitalized.

Better Bets vs. Fennec Pharmaceuticals (FENC)

Peer Outperformance in Biotechnology

FENC has outperformed 81% of its 363 Biotechnology peers over 5Y. Biotechnology ranks 9th of 10 industries in Health Care by median 5Y return. The sector’s gains have largely come from elsewhere.
Share of Biotechnology constituents that FENC has outperformed, by holding period. Peers without a full price history over a given window are excluded from that window.
1Y
69%
of 454 industry peers · 15.3% return
3Y
71%
of 401 industry peers · 60.8% return
5Y
81%
of 363 industry peers · 14.5% return
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Median price return by industry across the Health Care sector, ranked by 5Y. Biotechnology is FENC's own industry. Use this to see which corners of the sector have carried the returns.
Industry Names 1Y med3Y med5Y med Top 3 by 5Y
Health Care Distributors 6 13.9%45.7%94.9% CAH 443% · MCK 376% · COR 184%
Health Care Services 20 21.0%35.1%10.5% HIMS 280% · RDNT 141% · DGX 79%
Health Care Facilities 24 -0.8%5.1%4.8% THC 321% · NHC 279% · ENSG 139%
Managed Health Care 8 22.1%-7.9%-0.1% OSCR 123% · HQY 44% · ELV 12%
Health Care Equipment 50 -8.0%-3.8%-17.3% POCI 11563% · UFPT 346% · GKOS 257%
Pharmaceuticals 62 -10.6%0.2%-30.4% INDV 1090% · ETON 997% · LQDA 926%
Health Care Supplies 12 20.5%-8.5%-37.1% LNTH 322% · HAE 77% · MMSI 18%
Life Sciences Tools & Services 109 -10.9%-14.7%-64.2% SNWV 2286% · NTRA 243% · MEDP 219%
Biotechnology ← 364 -22.1%-23.8%-80.1% CELZ 1129% · DNTH 1093% · TRVI 969%
Health Care Technology 21 -38.6%-60.0%-82.5% SPOK 80% · HSTM 16% · VEEV -1%
Median of constituents with a full price history over each window. Top names are unfiltered by size in this render.

Latest Trefis Analyses

Title
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Recent Active Movers

Peer Comparisons

Peers to compare with:

Financials

FENCBYSIGTBPAGENVSTMKPTIMedian
NameFennec P.BeyondSp.GT Bioph.Agenus Verastem Karyopha. 
Mkt Price10.940.635.957.538.160.606.74
Mkt Cap0.40.00.00.30.80.00.2
Rev LTM59001338814773
Op Inc LTM-1-8-1636-160-82-12
FCF LTM-2-17-14-99-164-65-41
FCF 3Y Avg3-20-12-138-129-100-60
CFO LTM-2-17-14-99-162-65-41
CFO 3Y Avg3-19-12-136-128-100-59

Growth & Margins

FENCBYSIGTBPAGENVSTMKPTIMedian
NameFennec P.BeyondSp.GT Bioph.Agenus Verastem Karyopha. 
Rev Chg LTM77.8%--30.5%3,995.7%6.8%54.1%
Rev Chg 3Y Avg231.3%--18.3%-0.3%18.3%
Rev Chg Q85.2%--34.4%1,775.4%-11.9%59.8%
QoQ Delta Rev Chg LTM16.1%--7.1%76.5%-3.0%11.6%
Op Inc Chg LTM88.1%3.1%-51.1%139.2%-2.1%28.5%15.8%
Op Inc Chg 3Y Avg-19.6%43.5%0.5%68.1%-31.2%12.0%6.2%
Op Mgn LTM-2.0%--27.0%-182.6%-56.2%-29.1%
Op Mgn 3Y Avg-6.5%---44.7%-2,832.2%-76.7%-60.7%
QoQ Delta Op Mgn LTM9.1%--20.7%162.0%-0.4%14.9%
CFO/Rev LTM-3.4%---74.2%-185.3%-44.6%-59.4%
CFO/Rev 3Y Avg2.9%---104.6%-2,277.7%-69.7%-87.2%
FCF/Rev LTM-3.4%---74.2%-186.8%-44.6%-59.4%
FCF/Rev 3Y Avg2.9%---105.5%-2,278.3%-69.7%-87.6%

Valuation

FENCBYSIGTBPAGENVSTMKPTIMedian
NameFennec P.BeyondSp.GT Bioph.Agenus Verastem Karyopha. 
Mkt Cap0.40.00.00.30.80.00.2
P/S6.4--2.39.30.14.4
P/Op Inc-325.0-3.1-0.68.7-5.1-0.2-1.8
P/EBIT-171.9-3.1-0.32.1-4.1-0.1-1.7
P/E-116.2-3.9-1.93.4-4.0-0.1-2.9
P/CFO-185.3-1.5-0.6-3.2-5.0-0.3-2.4
Total Yield-0.9%-26.7%-51.4%29.5%-25.0%-1,294.4%-25.8%
Dividend Yield0.0%0.0%0.0%0.0%0.0%0.0%0.0%
FCF Yield 3Y Avg3.9%-35.0%-3,521.7%-101.1%-71.4%-721.6%-86.3%
D/E0.00.00.00.10.114.70.1
Net D/E-0.1-0.2-0.50.1-0.111.0-0.1

Returns

FENCBYSIGTBPAGENVSTMKPTIMedian
NameFennec P.BeyondSp.GT Bioph.Agenus Verastem Karyopha. 
1M Rtn-12.1%1.5%13.6%1.3%1.0%-65.0%1.2%
3M Rtn6.1%-57.7%1,230.5%132.4%51.1%-94.1%28.6%
6M Rtn70.9%-64.4%1,424.5%69.2%46.0%-92.6%57.6%
12M Rtn18.7%-64.8%450.9%80.6%-8.7%-89.8%5.0%
3Y Rtn65.5%-6.0%-17.4%-62.7%7.4%-96.8%-11.7%
1M Excs Rtn-7.8%-1.6%-2.2%8.1%1.1%-66.1%-1.9%
3M Excs Rtn1.7%-58.9%1,297.5%122.3%45.0%-96.7%23.4%
6M Excs Rtn56.8%-78.7%1,410.7%55.4%32.1%-106.4%43.8%
12M Excs Rtn-0.7%-81.1%675.9%61.5%-25.1%-105.3%-12.9%
3Y Excs Rtn-30.4%-103.6%-99.6%-146.9%-80.8%-180.7%-101.6%

Comparison Analyses

null

FDA Approved Drugs Data

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Post-Approval Fwd Returns
FDA
App #
Brand
Name
Generic
Name
Dosage
Form
FDA
Approval
3M
Rtn
6M
Rtn
1Y
Rtn
2Y
Rtn
Total
Rtn
NDA212937  PEDMARKsodium thiosulfatesolution920202228.3%4.7%-0.1%-30.7%39.3%
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Post-Approval Fwd Returns
FDA
App #
Brand
Name
Generic
Name
Dosage
Form
FDA
Approval
3M
Rtn
6M
Rtn
1Y
Rtn
2Y
Rtn
Total
Rtn
NDA212937  PEDMARKsodium thiosulfatesolution920202228.3%4.7%-0.1%-30.7%39.3%

Financials

Segment Financials

Revenue by Segment
$ Mil20252024202320222020
Gross product revenues5439   
Discounts and allowances-9-9   
Licensing revenue 18   
Production and commercialization of PEDMARK  21 0
Net product revenues   2 
Total45482120


Assets by Segment
$ Mil20212019201820172016
Production and commercialization of PEDMARK221423284
Total221423284


Price Behavior

Price Behavior
Market Price$10.63 
Market Cap ($ Bil)0.4 
First Trading Date12/29/2006 
Distance from 52W High-16.8% 
   50 Days200 Days
DMA Price$11.18$8.97
DMA Trendupup
Distance from DMA-4.9%18.5%
 3M1YR
Volatility59.4%66.9%
Downside Capture70.05134.05
Upside Capture75.36127.80
Correlation (SPY)22.4%26.1%
FENC Betas & Captures as of 9/30/2026

 1M2M3M6M1Y3Y
Beta1.761.351.271.471.360.98
Up Beta1.841.911.952.011.760.64
Down Beta2.443.531.50-0.140.970.85
Up Capture106%126%95%260%159%167%
Bmk +ve Days6162766132424
Stock +ve Days9223168125362
Down Capture292%43%112%122%124%107%
Bmk -ve Days16263760120328
Stock -ve Days13193256122370

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with FENC
FENC12.2%66.8%0.42-
Sector ETF (XLV)18.2%15.7%0.8619.9%
Equity (SPY)16.7%13.0%0.9125.9%
Gold (GLD)3.4%29.6%0.114.8%
Commodities (DBC)45.0%20.9%1.67-19.7%
Real Estate (VNQ)2.8%13.7%-0.0516.6%
Bitcoin (BTCUSD)-31.7%44.2%-0.7315.1%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with FENC
FENC2.6%59.9%0.30-
Sector ETF (XLV)7.4%15.2%0.2917.9%
Equity (SPY)14.0%17.1%0.6319.8%
Gold (GLD)18.2%18.9%0.782.7%
Commodities (DBC)10.3%19.6%0.40-0.1%
Real Estate (VNQ)1.3%18.8%-0.0415.1%
Bitcoin (BTCUSD)13.7%52.2%0.439.7%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with FENC
FENC-1.1%59.7%0.24-
Sector ETF (XLV)10.6%16.7%0.5120.7%
Equity (SPY)15.4%17.9%0.7324.9%
Gold (GLD)11.6%16.4%0.585.9%
Commodities (DBC)8.3%18.1%0.379.3%
Real Estate (VNQ)4.2%20.7%0.1619.1%
Bitcoin (BTCUSD)63.6%66.2%1.0312.0%

Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date9152026
Short Interest: Shares Quantity0.5 Mil
Short Interest: % Change Since 83120264.7%
Average Daily Volume0.3 Mil
Days-to-Cover Short Interest2.1 days
Basic Shares Quantity34.5 Mil
Short % of Basic Shares1.6%

Earnings Returns History

Updated 6/10/2026
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 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
3/24/20262.5%2.2%10.6%
3/10/20254.7%3.4%-18.0%
3/25/2024-1.0%-0.1%-17.5%
11/7/2023-6.6%-0.7%14.1%
8/4/20230.2%4.5%4.5%
SUMMARY STATS   
# Positive333
# Negative222
Median Positive2.5%3.4%10.6%
Median Negative-3.8%-0.4%-17.8%
Max Positive4.7%4.5%14.1%
Max Negative-6.6%-0.7%-18.0%
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 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
3/24/20262.5%2.2%10.6%
3/10/20254.7%3.4%-18.0%
3/25/2024-1.0%-0.1%-17.5%
11/7/2023-6.6%-0.7%14.1%
8/4/20230.2%4.5%4.5%
SUMMARY STATS   
# Positive333
# Negative222
Median Positive2.5%3.4%10.6%
Median Negative-3.8%-0.4%-17.8%
Max Positive4.7%4.5%14.1%
Max Negative-6.6%-0.7%-18.0%

SEC Filings

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Report DateFiling DateFiling
06/30/202608/13/202610-Q
12/31/202503/27/202610-K
09/30/202511/13/202510-Q
06/30/202508/14/202510-Q
03/31/202505/14/202510-Q
12/31/202403/26/202510-K
09/30/202411/08/202410-Q
06/30/202408/13/202410-Q
03/31/202405/14/202410-Q
12/31/202303/29/202410-K
09/30/202311/09/202310-Q
06/30/202308/07/202310-Q
03/31/202305/12/202310-Q
12/31/202203/29/202310-K
09/30/202211/14/202210-Q
06/30/202208/12/202210-Q
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Report DateFiling DateFiling
06/30/202608/13/202610-Q
12/31/202503/27/202610-K
09/30/202511/13/202510-Q
06/30/202508/14/202510-Q
03/31/202505/14/202510-Q
12/31/202403/26/202510-K
09/30/202411/08/202410-Q
06/30/202408/13/202410-Q
03/31/202405/14/202410-Q
12/31/202303/29/202410-K
09/30/202311/09/202310-Q
06/30/202308/07/202310-Q
03/31/202305/12/202310-Q
12/31/202203/29/202310-K
09/30/202211/14/202210-Q
06/30/202208/12/202210-Q
03/31/202205/12/202210-Q
12/31/202102/28/202210-K
09/30/202111/10/202110-Q
06/30/202108/10/202110-Q
03/31/202105/13/202110-Q
12/31/202003/30/202110-K
09/30/202011/16/202010-Q
06/30/202008/05/202010-Q
03/31/202005/14/202010-Q
12/31/201902/14/202010-K
09/30/201911/12/201910-Q
06/30/201908/09/201910-Q

Insider Activity

Updated 9/16/2026
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#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Brughera, Marco MariaDirectSell916202610.2915,545  Form
2Raykov, RostyDirectSell901202612.1110,000121,1001,506,617Form
3Sayad, Pierre SargisChief Medical OfficerDirectSell831202612.1812,000146,160115,941Form
4Andrade, RobertCHIEF FINANCIAL OFFICERDirectSell828202611.7875,000883,5002,564,212Form
5Raykov, RostyDirectSell80420269.5810,00095,8001,261,044Form
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#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Brughera, Marco MariaDirectSell916202610.2915,545  Form
2Raykov, RostyDirectSell901202612.1110,000121,1001,506,617Form
3Sayad, Pierre SargisChief Medical OfficerDirectSell831202612.1812,000146,160115,941Form
4Andrade, RobertCHIEF FINANCIAL OFFICERDirectSell828202611.7875,000883,5002,564,212Form
5Raykov, RostyDirectSell80420269.5810,00095,8001,261,044Form
6Raykov, RostyDirectSell702202610.419,59999,9261,445,481Form
7Raykov, RostyDirectSell60220269.629,74793,7661,251,360Form
8Rallis, Chris ADirectSell51220267.048,34658,756444,062Form
9Raykov, RostyDirectSell50120266.4710,78169,753785,788Form
10Raykov, RostyDirectSell40220266.3110,94669,069718,431Form
11Raykov, RostyDirectSell30320268.3610,07984,260869,407Form
12Raykov, RostyDirectSell20220267.7610,34980,308764,182Form
13Raykov, RostyDirectSell10520267.6010,31278,371668,952Form
14Southpoint, Capital Advisors LP See FootnoteSell122920257.501,000,0007,500,00020,585,558Form
15Raykov, RostyDirectSell120520257.5410,00075,400584,546Form
16Southpoint, Capital Advisors LP See FootnoteSell112020258.7919,341170,04832,924,137Form
17Southpoint, Capital Advisors LP See FootnoteSell111720258.7985,918755,19333,085,152Form
18Southpoint, Capital Advisors LP See FootnoteSell111720258.00160,1001,280,43230,791,145Form
19Raykov, RostyDirectSell110620258.1010,00081,000666,776Form
20Rallis, Chris ADirectSell101420259.241,77516,401527,410Form
21Southpoint, Capital Advisors LP See FootnoteSell100920259.3520,609192,61437,478,796Form
22Southpoint, Capital Advisors LP See FootnoteSell100920259.4719,605185,72238,183,712Form
23Southpoint, Capital Advisors LP See FootnoteSell100920259.5926,900257,89338,830,765Form
24Raykov, RostyDirectSell100620259.7810,00097,800806,860Form
25Raykov, RostyDirectSell90420258.9210,00089,200455,687Form

Investor Activity (13F)

Updated Oct 9, 2026
13F holdings as of Mar 31, 2026 (Q1 2026)

Active managers (13F portfolio over $250M, at least 3 holdings) with a position over $5M that is either over 10% of their portfolio or held in a concentrated book of 50 or fewer total positions. Index/ETF, sovereign, bank, community-bank and charitable/donor-advised filers are excluded.

Active ManagerValue% of PortfolioTotal PositionsQoQFiling
Southpoint Capital Advisors LP$16.9 Mil0.3%41Hold13F
Active Manager
Active Manager
Active ManagerValue% of PortfolioTotal PositionsQoQFiling
Southpoint Capital Advisors LP$16.9 Mil0.3%41Hold13F
Core Cache Last Updated: 10/8/2026