Tearsheet

TNF Pharmaceuticals (TNFA)


Market Price (9/30/2025): $4.04 | Market Cap: $0.6 Mil
Sector: Health Care | Industry: Biotechnology

TNF Pharmaceuticals (TNFA)


Market Price (9/30/2025): $4.04
Market Cap: $0.6 Mil
Sector: Health Care
Industry: Biotechnology

Investment Highlights

0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -517%
Weak multi-year price returns
2Y Excs Rtn is -153%, 3Y Excs Rtn is -177%
Very low revenue
Rev LTMTotal Revenue or Sales, Last Twelve Months is 0
1   Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -8.4 Mil
2   Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -941%
3   High stock price volatility
Vol 12M is 7771%
4   Significant short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 198%
0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -517%
1 Weak multi-year price returns
2Y Excs Rtn is -153%, 3Y Excs Rtn is -177%
2 Very low revenue
Rev LTMTotal Revenue or Sales, Last Twelve Months is 0
3 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -8.4 Mil
4 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -941%
5 High stock price volatility
Vol 12M is 7771%
6 Significant short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 198%

Market Valuation

 9/30/252024202320222021
Share Price CYE$4.04$115.00$776.10$3,450.00$18,180.00
Market Cap CYE ($ Mil)0.6330.61,397.64,576.722,951.8
Total Debt ($ Mil)0.00.00.00.10.1
Total Cash ($ Mil)3.88.54.94.811.6
Enterprise Value ($ Mil)-3.2330.61,397.64,576.822,951.9
Valuation Ratios     
P/S TTM0.00.00.00.00.0
P/EBIT TTM-0.10.0-0.0-0.0-0.1
P/E TTM-0.10.0-0.0-0.0-0.1
Sector Ratios     
P/S TTM (Sector)3.73.64.04.57.3
P/EBIT TTM (Sector)-1.6-1.3-1.4-1.3-2.8
P/E TTM (Sector)-1.9-1.5-1.5-1.3-2.8
 9/30/2520242023
Share Price CYE$4.04$115.00$776.10
Market Cap CYE ($ Mil)0.6330.61,397.6
Total Debt ($ Mil)0.00.00.0
Total Cash ($ Mil)3.88.54.9
Enterprise Value ($ Mil)-3.2330.61,397.6
Valuation Ratios   
P/S TTM0.00.00.0
P/EBIT TTM-0.10.0-0.0
P/E TTM-0.10.0-0.0
Sector Ratios   
P/S TTM (Sector)3.73.64.0
P/EBIT TTM (Sector)-1.6-1.3-1.4
P/E TTM (Sector)-1.9-1.5-1.5

Business Description

TNF Pharmaceuticals, Inc., a clinical stage pharmaceutical company, focuses on developing two novel therapeutic platforms that treat the causes of disease rather than addressing the symptoms. Its MYMD-1 is a drug platform based on a clinical stage small molecule that regulates the immune system to control TNF-a, which drives chronic inflammation, and other pro-inflammatory cell signaling cytokines. The MYMD-1 is being developed to treat diseases and disorders marked by acute or chronic inflammation. Show more

Price Returns Compared

Expand for Detailed View

 202020212022202320242025Total [1]
Returns
TNFA Return-38%52%-81%-78%-85%-96%-100%
Peers Return75%-16%-34%-21%-51%47%-45%
S&P 500 Return16%27%-19%24%23%13%106%

[1] Cumulative total returns since the beginning of 2020
[2] Peers: VRTX, EDIT, INFIQ, SRNE, STA.
[3] 2025 data is for the year up to 9/29/2025 (YTD)

Better Bets than TNF Pharmaceuticals (TNFA)

Trade Ideas

Select past trade ideas related to TNFA and Biotechnology.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
LNTH_8312025_Dip_Buyer_High_CFO_Margins_ExInd_DE08312025LNTHLantheusDip BuyDB | CFO/Rev | Low D/EDip Buy with High Cash Flow Margins
Buying dips for companies with significant cash flows from operations and reasonable debt / market cap
-7.8%-7.8%-8.7%
COO_8312025_Monopoly_xInd_xCD_Getting_Cheaper08312025COOCooper CompaniesMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
0.2%0.2%-4.6%
WST_8312025_Monopoly_xInd_xCD_Getting_Cheaper08312025WSTWest Pharmaceutical ServicesMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
5.9%5.9%-1.3%
BMY_7312025_Dip_Buyer_FCFYield07312025BMYBristol-Myers SquibbDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
1.9%1.9%0.0%
UTHR_7312025_Dip_Buyer_FCFYield07312025UTHRUnited TherapeuticsDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
57.5%57.5%0.0%
Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
LNTH_8312025_Dip_Buyer_High_CFO_Margins_ExInd_DE08312025LNTHLantheusDip BuyDB | CFO/Rev | Low D/EDip Buy with High Cash Flow Margins
Buying dips for companies with significant cash flows from operations and reasonable debt / market cap
-7.8%-7.8%-8.7%
COO_8312025_Monopoly_xInd_xCD_Getting_Cheaper08312025COOCooper CompaniesMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
0.2%0.2%-4.6%
WST_8312025_Monopoly_xInd_xCD_Getting_Cheaper08312025WSTWest Pharmaceutical ServicesMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
5.9%5.9%-1.3%
BMY_7312025_Dip_Buyer_FCFYield07312025BMYBristol-Myers SquibbDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
1.9%1.9%0.0%
UTHR_7312025_Dip_Buyer_FCFYield07312025UTHRUnited TherapeuticsDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
57.5%57.5%0.0%

See Trefis Trade Ideas for more.

Recent Active Movers

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Peer Comparisons for TNF Pharmaceuticals

Financials

TNFAVRTXEDITINFIQSRNESTAMedian
NameTNF Phar.Vertex P.Editas M.Infinity.Sorrento.Starton . 
Mkt Price4.70395.313.52---4.70
Mkt Cap0.0101.50.3---0.3
Rev LTM011,41939--019
Op Inc LTM-8-199-161---11-86
FCF LTM-93,500-205----9
FCF 3Y Avg-111,984-182----11
CFO LTM-93,846-201----9
CFO 3Y Avg-112,324-177----11

Growth & Margins

TNFAVRTXEDITINFIQSRNESTAMedian
NameTNF Phar.Vertex P.Editas M.Infinity.Sorrento.Starton . 
Rev Chg LTM-10.5%-42.0%----15.8%
Rev Chg 3Y Avg-11.0%55.3%---33.1%
Rev Chg Q-12.1%597.5%---304.8%
QoQ Delta Rev Chg LTM-2.9%8.6%---5.7%
Op Mgn LTM--1.7%-413.4%----207.5%
Op Mgn 3Y Avg-26.5%-616.5%----295.0%
QoQ Delta Op Mgn LTM-2.0%164.9%---83.5%
CFO/Rev LTM-33.7%-517.6%----242.0%
CFO/Rev 3Y Avg-22.5%-538.7%----258.1%
FCF/Rev LTM-30.6%-526.8%----248.1%
FCF/Rev 3Y Avg-19.2%-552.8%----266.8%

Valuation

TNFAVRTXEDITINFIQSRNESTAMedian
NameTNF Phar.Vertex P.Editas M.Infinity.Sorrento.Starton . 
Mkt Cap0.0101.50.3---0.3
P/S-8.97.6---8.3
P/EBIT-0.123.1-1.3----0.1
P/E-0.127.9-1.3----0.1
P/CFO-0.126.4-1.5----0.1
Total Yield-937.1%3.6%-79.7%----79.7%
Dividend Yield0.0%0.0%0.0%---0.0%
FCF Yield 3Y Avg-24,326.3%2.1%-61.3%----61.3%
D/E0.00.00.1---0.0
Net D/E-5.2-0.0-0.5----0.5

Returns

TNFAVRTXEDITINFIQSRNESTAMedian
NameTNF Phar.Vertex P.Editas M.Infinity.Sorrento.Starton . 
1M Rtn9,630.8%1.1%37.0%---37.0%
3M Rtn-61.7%-11.2%60.0%----11.2%
6M Rtn-86.6%-18.5%203.4%----18.5%
12M Rtn-96.9%-14.6%1.1%----14.6%
3Y Rtn-99.9%36.5%-71.2%----71.2%
1M Excs Rtn7,527.4%-1.6%30.4%---30.4%
3M Excs Rtn-69.1%-18.6%52.6%----18.6%
6M Excs Rtn-106.3%-39.1%162.2%----39.1%
12M Excs Rtn-113.5%-30.8%-12.6%----30.8%
3Y Excs Rtn-177.2%-39.2%-150.7%----150.7%

Financials

Price Behavior

Short Interest

Short Interest: As Of Date9152025
Short Interest: Shares Quantity311,340
Short Interest: % Change Since 8312025-94.6%
Average Daily Volume626,202
Days-to-Cover Short Interest1
Basic Shares Quantity156,988
Short % of Basic Shares198.3%

Earnings Returns History

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 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
11/15/2018-29.5%-25.6%-55.9%
SUMMARY STATS   
# Positive000
# Negative111
Median Positive   
Median Negative-29.5%-25.6%-55.9%
Max Positive   
Max Negative-29.5%-25.6%-55.9%

SEC Filings

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Report DateFiling DateFiling
6302025819202510-Q 6/30/2025
3312025515202510-Q 3/31/2025
12312024411202510-K 12/31/2024
93020241114202410-Q 9/30/2024
6302024819202410-Q 6/30/2024
3312024515202410-Q 3/31/2024
12312023401202410-K 12/31/2023
93020231114202310-Q 9/30/2023
6302023814202310-Q 6/30/2023
3312023515202310-Q 3/31/2023
12312022331202310-K 12/31/2022
93020221110202210-Q 9/30/2022
6302022815202210-Q 6/30/2022
3312022516202210-Q 3/31/2022
12312021331202210-K 12/31/2021
93020211112202110-Q 9/30/2021

Insider Activity

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