TNF Pharmaceuticals (TNFA)
Market Price (9/30/2025): $4.04 | Market Cap: $0.6 MilSector: Health Care | Industry: Biotechnology
TNF Pharmaceuticals (TNFA)
Market Price (9/30/2025): $4.04Market Cap: $0.6 MilSector: Health CareIndustry: Biotechnology
Investment Highlights
| Cash is significant % of market capNet D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -517% | Weak multi-year price returns2Y Excs Rtn is -153%, 3Y Excs Rtn is -177% | Very low revenueRev LTMTotal Revenue or Sales, Last Twelve Months is 0 |
| Not profitable at operating income levelOp Inc LTMOperating Income, Last Twelve Months is -8.4 Mil | ||
| Yield minus risk free rate is negativeERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -941% | ||
| High stock price volatilityVol 12M is 7771% | ||
| Significant short interestShort Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 198% |
| Cash is significant % of market capNet D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -517% |
| Weak multi-year price returns2Y Excs Rtn is -153%, 3Y Excs Rtn is -177% |
| Very low revenueRev LTMTotal Revenue or Sales, Last Twelve Months is 0 |
| Not profitable at operating income levelOp Inc LTMOperating Income, Last Twelve Months is -8.4 Mil |
| Yield minus risk free rate is negativeERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -941% |
| High stock price volatilityVol 12M is 7771% |
| Significant short interestShort Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 198% |
Market Valuation
| 9/30/25 | 2024 | 2023 | 2022 | 2021 | |
|---|---|---|---|---|---|
| Share Price CYE | $4.04 | $115.00 | $776.10 | $3,450.00 | $18,180.00 |
| Market Cap CYE ($ Mil) | 0.6 | 330.6 | 1,397.6 | 4,576.7 | 22,951.8 |
| Total Debt ($ Mil) | 0.0 | 0.0 | 0.0 | 0.1 | 0.1 |
| Total Cash ($ Mil) | 3.8 | 8.5 | 4.9 | 4.8 | 11.6 |
| Enterprise Value ($ Mil) | -3.2 | 330.6 | 1,397.6 | 4,576.8 | 22,951.9 |
| Valuation Ratios | |||||
| P/S TTM | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| P/EBIT TTM | -0.1 | 0.0 | -0.0 | -0.0 | -0.1 |
| P/E TTM | -0.1 | 0.0 | -0.0 | -0.0 | -0.1 |
| Sector Ratios | |||||
| P/S TTM (Sector) | 3.7 | 3.6 | 4.0 | 4.5 | 7.3 |
| P/EBIT TTM (Sector) | -1.6 | -1.3 | -1.4 | -1.3 | -2.8 |
| P/E TTM (Sector) | -1.9 | -1.5 | -1.5 | -1.3 | -2.8 |
| 9/30/25 | 2024 | 2023 | |
|---|---|---|---|
| Share Price CYE | $4.04 | $115.00 | $776.10 |
| Market Cap CYE ($ Mil) | 0.6 | 330.6 | 1,397.6 |
| Total Debt ($ Mil) | 0.0 | 0.0 | 0.0 |
| Total Cash ($ Mil) | 3.8 | 8.5 | 4.9 |
| Enterprise Value ($ Mil) | -3.2 | 330.6 | 1,397.6 |
| Valuation Ratios | |||
| P/S TTM | 0.0 | 0.0 | 0.0 |
| P/EBIT TTM | -0.1 | 0.0 | -0.0 |
| P/E TTM | -0.1 | 0.0 | -0.0 |
| Sector Ratios | |||
| P/S TTM (Sector) | 3.7 | 3.6 | 4.0 |
| P/EBIT TTM (Sector) | -1.6 | -1.3 | -1.4 |
| P/E TTM (Sector) | -1.9 | -1.5 | -1.5 |
Business Description
TNF Pharmaceuticals, Inc., a clinical stage pharmaceutical company, focuses on developing two novel therapeutic platforms that treat the causes of disease rather than addressing the symptoms. Its MYMD-1 is a drug platform based on a clinical stage small molecule that regulates the immune system to control TNF-a, which drives chronic inflammation, and other pro-inflammatory cell signaling cytokines. The MYMD-1 is being developed to treat diseases and disorders marked by acute or chronic inflammation.
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Price Returns Compared
Expand for Detailed View| 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total [1] | |
|---|---|---|---|---|---|---|---|
| Returns | |||||||
| TNFA Return | -38% | 52% | -81% | -78% | -85% | -96% | -100% |
| Peers Return | 75% | -16% | -34% | -21% | -51% | 47% | -45% |
| S&P 500 Return | 16% | 27% | -19% | 24% | 23% | 13% | 106% |
[1] Cumulative total returns since the beginning of 2020
[2] Peers: VRTX, EDIT, INFIQ, SRNE, STA.
[3] 2025 data is for the year up to 9/29/2025 (YTD)
Trade Ideas
Select past trade ideas related to TNFA and Biotechnology.
| Date | Ticker | Company | Category | Trade Strategy | 6M Fwd Rtn | 12M Fwd Rtn | 12M Max DD |
|---|---|---|---|---|---|---|---|
| 08312025 | LNTH | Lantheus | Dip Buy | DB | CFO/Rev | Low D/EDip Buy with High Cash Flow MarginsBuying dips for companies with significant cash flows from operations and reasonable debt / market cap | -7.8% | -7.8% | -8.7% |
| 08312025 | COO | Cooper Companies | Monopoly | MY | Getting CheaperMonopoly-Like with P/S DeclineLarge cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple | 0.2% | 0.2% | -4.6% |
| 08312025 | WST | West Pharmaceutical Services | Monopoly | MY | Getting CheaperMonopoly-Like with P/S DeclineLarge cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple | 5.9% | 5.9% | -1.3% |
| 07312025 | BMY | Bristol-Myers Squibb | Dip Buy | DB | FCFY OPMDip Buy with High FCF Yield and High MarginBuying dips for companies with high FCF yield and meaningfully high operating margin | 1.9% | 1.9% | 0.0% |
| 07312025 | UTHR | United Therapeutics | Dip Buy | DB | FCFY OPMDip Buy with High FCF Yield and High MarginBuying dips for companies with high FCF yield and meaningfully high operating margin | 57.5% | 57.5% | 0.0% |
| Date | Ticker | Company | Category | Trade Strategy | 6M Fwd Rtn | 12M Fwd Rtn | 12M Max DD |
|---|---|---|---|---|---|---|---|
| 08312025 | LNTH | Lantheus | Dip Buy | DB | CFO/Rev | Low D/EDip Buy with High Cash Flow MarginsBuying dips for companies with significant cash flows from operations and reasonable debt / market cap | -7.8% | -7.8% | -8.7% |
| 08312025 | COO | Cooper Companies | Monopoly | MY | Getting CheaperMonopoly-Like with P/S DeclineLarge cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple | 0.2% | 0.2% | -4.6% |
| 08312025 | WST | West Pharmaceutical Services | Monopoly | MY | Getting CheaperMonopoly-Like with P/S DeclineLarge cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple | 5.9% | 5.9% | -1.3% |
| 07312025 | BMY | Bristol-Myers Squibb | Dip Buy | DB | FCFY OPMDip Buy with High FCF Yield and High MarginBuying dips for companies with high FCF yield and meaningfully high operating margin | 1.9% | 1.9% | 0.0% |
| 07312025 | UTHR | United Therapeutics | Dip Buy | DB | FCFY OPMDip Buy with High FCF Yield and High MarginBuying dips for companies with high FCF yield and meaningfully high operating margin | 57.5% | 57.5% | 0.0% |
See Trefis Trade Ideas for more.
Research & Analysis
Invest in Strategies
Wealth Management
Peer Comparisons for TNF Pharmaceuticals
Financials
| Median | |
|---|---|
| Name | |
| Mkt Price | 4.70 |
| Mkt Cap | 0.3 |
| Rev LTM | 19 |
| Op Inc LTM | -86 |
| FCF LTM | -9 |
| FCF 3Y Avg | -11 |
| CFO LTM | -9 |
| CFO 3Y Avg | -11 |
Growth & Margins
| Median | |
|---|---|
| Name | |
| Rev Chg LTM | -15.8% |
| Rev Chg 3Y Avg | 33.1% |
| Rev Chg Q | 304.8% |
| QoQ Delta Rev Chg LTM | 5.7% |
| Op Mgn LTM | -207.5% |
| Op Mgn 3Y Avg | -295.0% |
| QoQ Delta Op Mgn LTM | 83.5% |
| CFO/Rev LTM | -242.0% |
| CFO/Rev 3Y Avg | -258.1% |
| FCF/Rev LTM | -248.1% |
| FCF/Rev 3Y Avg | -266.8% |
Valuation
| Median | |
|---|---|
| Name | |
| Mkt Cap | 0.3 |
| P/S | 8.3 |
| P/EBIT | -0.1 |
| P/E | -0.1 |
| P/CFO | -0.1 |
| Total Yield | -79.7% |
| Dividend Yield | 0.0% |
| FCF Yield 3Y Avg | -61.3% |
| D/E | 0.0 |
| Net D/E | -0.5 |
Returns
| Median | |
|---|---|
| Name | |
| 1M Rtn | 37.0% |
| 3M Rtn | -11.2% |
| 6M Rtn | -18.5% |
| 12M Rtn | -14.6% |
| 3Y Rtn | -71.2% |
| 1M Excs Rtn | 30.4% |
| 3M Excs Rtn | -18.6% |
| 6M Excs Rtn | -39.1% |
| 12M Excs Rtn | -30.8% |
| 3Y Excs Rtn | -150.7% |
Earnings Returns History
Expand for More| Forward Returns | |||
|---|---|---|---|
| Earnings Date | 1D Returns | 5D Returns | 21D Returns |
| 11/15/2018 | -29.5% | -25.6% | -55.9% |
| SUMMARY STATS | |||
| # Positive | 0 | 0 | 0 |
| # Negative | 1 | 1 | 1 |
| Median Positive | |||
| Median Negative | -29.5% | -25.6% | -55.9% |
| Max Positive | |||
| Max Negative | -29.5% | -25.6% | -55.9% |
SEC Filings
Expand for More| Report Date | Filing Date | Filing |
|---|---|---|
| 6302025 | 8192025 | 10-Q 6/30/2025 |
| 3312025 | 5152025 | 10-Q 3/31/2025 |
| 12312024 | 4112025 | 10-K 12/31/2024 |
| 9302024 | 11142024 | 10-Q 9/30/2024 |
| 6302024 | 8192024 | 10-Q 6/30/2024 |
| 3312024 | 5152024 | 10-Q 3/31/2024 |
| 12312023 | 4012024 | 10-K 12/31/2023 |
| 9302023 | 11142023 | 10-Q 9/30/2023 |
| 6302023 | 8142023 | 10-Q 6/30/2023 |
| 3312023 | 5152023 | 10-Q 3/31/2023 |
| 12312022 | 3312023 | 10-K 12/31/2022 |
| 9302022 | 11102022 | 10-Q 9/30/2022 |
| 6302022 | 8152022 | 10-Q 6/30/2022 |
| 3312022 | 5162022 | 10-Q 3/31/2022 |
| 12312021 | 3312022 | 10-K 12/31/2021 |
| 9302021 | 11122021 | 10-Q 9/30/2021 |
Industry Resources
External Quote Links
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