Tearsheet

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0 Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 147%
Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 10.61, Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 11%
Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -107 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -1101%
1 Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, Precision Medicine, and Aging Population & Chronic Disease. Themes include Gene Editing & Therapy, Show more.
  Expensive valuation multiples
P/SPrice/Sales ratio is 142x
2   Stock price has recently run up significantly
12M Rtn12 month market price return is 142%
3   Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 112%
4   Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -907%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -928%
5   Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -22%
6   High stock price volatility
Vol 12M is 107%
7   Key risks
PGEN key risks include [1] a history of substantial net losses and a high cash burn rate necessitating additional financing, Show more.
0 Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 147%
1 Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, Precision Medicine, and Aging Population & Chronic Disease. Themes include Gene Editing & Therapy, Show more.
2 Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 10.61, Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 11%
3 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -107 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -1101%
4 Expensive valuation multiples
P/SPrice/Sales ratio is 142x
5 Stock price has recently run up significantly
12M Rtn12 month market price return is 142%
6 Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 112%
7 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -907%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -928%
8 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -22%
9 High stock price volatility
Vol 12M is 107%
10 Key risks
PGEN key risks include [1] a history of substantial net losses and a high cash burn rate necessitating additional financing, Show more.

Valuation, Metrics & Events

Price Chart

Why The Stock Moved

Qualitative Assessment

AI Analysis | Feedback

Precigen (PGEN) stock has remained largely at the same level since 11/30/2025 because of the following key factors:

1. Mixed Q4 2025 Financial Performance and Outlook.

Precigen reported Q4 2025 earnings per share (EPS) of -$0.01 on March 25, 2026, which significantly beat analyst estimates of -$0.09 by 89.47%. However, this positive surprise was largely offset by a revenue miss, as the reported revenue of $4.57 million fell short of the estimated $8.45 million. This divergence between better-than-expected earnings and lower-than-expected revenue likely created a balanced, rather than decisive, impact on investor sentiment, contributing to the stock remaining largely at the same level.

2. Early PAPZIMEOS Commercialization Progress Amidst Initial Revenue Expectations.

The commercial launch of PAPZIMEOS, the first and only FDA-approved treatment for adult recurrent respiratory papillomatosis (RRP), began in November 2025, generating $3.4 million in net product revenue for Q4 2025. Management provided a positive outlook, anticipating Q1 2026 revenue to exceed $18 million and expecting to achieve cash flow breakeven by the end of 2026. Despite these strong commercial signals and a broadening payer coverage to 215 million lives by January 2026, the initial Q4 product revenue, when viewed against broader analyst revenue estimates, may have curbed more substantial upward stock movement.

Show more

Stock Movement Drivers

Fundamental Drivers

The 1.6% change in PGEN stock from 11/30/2025 to 3/26/2026 was primarily driven by a 53.5% change in the company's Total Revenues ($ Mil).
(LTM values as of)113020253262026Change
Stock Price ($)3.833.891.6%
Change Contribution By: 
Total Revenues ($ Mil)61053.5%
P/S Multiple186.5142.3-23.7%
Shares Outstanding (Mil)307354-13.3%
Cumulative Contribution1.6%

LTM = Last Twelve Months as of date shown

Market Drivers

11/30/2025 to 3/26/2026
ReturnCorrelation
PGEN1.6% 
Market (SPY)-5.3%5.3%
Sector (XLV)-7.2%27.1%

Fundamental Drivers

The -13.7% change in PGEN stock from 8/31/2025 to 3/26/2026 was primarily driven by a -53.8% change in the company's P/S Multiple.
(LTM values as of)83120253262026Change
Stock Price ($)4.513.89-13.7%
Change Contribution By: 
Total Revenues ($ Mil)410123.1%
P/S Multiple308.0142.3-53.8%
Shares Outstanding (Mil)296354-16.3%
Cumulative Contribution-13.7%

LTM = Last Twelve Months as of date shown

Market Drivers

8/31/2025 to 3/26/2026
ReturnCorrelation
PGEN-13.7% 
Market (SPY)0.6%10.8%
Sector (XLV)7.0%15.9%

Fundamental Drivers

The 124.9% change in PGEN stock from 2/28/2025 to 3/26/2026 was primarily driven by a 144.4% change in the company's Total Revenues ($ Mil).
(LTM values as of)22820253262026Change
Stock Price ($)1.733.89124.9%
Change Contribution By: 
Total Revenues ($ Mil)410144.4%
P/S Multiple120.4142.318.2%
Shares Outstanding (Mil)276354-22.1%
Cumulative Contribution124.9%

LTM = Last Twelve Months as of date shown

Market Drivers

2/28/2025 to 3/26/2026
ReturnCorrelation
PGEN124.9% 
Market (SPY)9.8%29.4%
Sector (XLV)-0.4%30.7%

Fundamental Drivers

The 208.7% change in PGEN stock from 2/28/2023 to 3/26/2026 was primarily driven by a 1522.7% change in the company's P/S Multiple.
(LTM values as of)22820233262026Change
Stock Price ($)1.263.89208.7%
Change Contribution By: 
Total Revenues ($ Mil)2910-66.4%
P/S Multiple8.8142.31522.7%
Shares Outstanding (Mil)201354-43.4%
Cumulative Contribution208.7%

LTM = Last Twelve Months as of date shown

Market Drivers

2/28/2023 to 3/26/2026
ReturnCorrelation
PGEN208.7% 
Market (SPY)69.4%28.7%
Sector (XLV)20.4%27.7%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
PGEN Return-64%-59%-12%-16%273%-26%-70%
Peers Return-26%-62%19%-52%-3%21%-81%
S&P 500 Return27%-19%24%23%16%-4%75%

Monthly Win Rates [3]
PGEN Win Rate17%33%42%50%67%33% 
Peers Win Rate33%33%45%33%43%53% 
S&P 500 Win Rate75%42%67%75%67%33% 

Max Drawdowns [4]
PGEN Max Drawdown-65%-69%-42%-50%-4%-26% 
Peers Max Drawdown-55%-65%-39%-54%-42%-10% 
S&P 500 Max Drawdown-1%-25%-1%-2%-15%-5% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: CRSP, NTLA, EDIT, IOVA, NKTX.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 3/26/2026 (YTD)

How Low Can It Go

Unique KeyEventPGENS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-92.0%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven1146.4%34.1%
2022 Inflation ShockTime to BreakevenTime to BreakevenNot Fully Recovered days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-79.7%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven392.5%51.3%
2020 Covid PandemicTime to BreakevenTime to Breakeven253 days148 days
2018 Correction2018 Correction  
2018 Correction% Loss% Loss-84.5%-19.8%
2018 Correction% Gain to Breakeven% Gain to Breakeven544.8%24.7%
2018 CorrectionTime to BreakevenTime to BreakevenNot Fully Recovered days120 days

Compare to CRSP, NTLA, EDIT, IOVA, NKTX

In The Past

Precigen's stock fell -92.0% during the 2022 Inflation Shock from a high on 1/4/2021. A -92.0% loss requires a 1146.4% gain to breakeven.

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About Precigen (PGEN)

Precigen, Inc. discovers and develops the next generation of gene and cellular therapies in the United States. It also provides disease-modifying therapeutics; genetically engineered swine for regenerative medicine applications; and reproductive and embryo transfer technologies. In addition, the company offers UltraVector platform that incorporates advanced DNA construction technologies and computational models to design and assemble genetic components into complex gene expression programs; mbIL15, a gene that enhances functional characteristics of immune cells; Sleeping Beauty, a non-viral transposon/transposase system; AttSite recombinases, which breaks and rejoins DNA at specific sequences; AdenoVerse technology platform, a library of engineered adenovector serotypes; and L. lactis is a food-grade bacterium. Additionally, it provides RheoSwitch, an inducible gene switch system that provides quantitative dose-proportionate regulation of the amount and timing of target protein expression; kill switches to selectively eliminate cell therapies in vivo; tissue-specific promoters; UltraCAR-T platform for the treatment of cancer; AdenoVerse Immunotherapy, a library of proprietary adenovectors for the gene delivery; and ActoBiotics platform, genetically modified bacteria that deliver proteins and peptides at mucosal sites. Precigen, Inc. has collaboration and license agreements with Alaunos Therapeutics, Inc.; Ares Trading S.A.; Oragenics, Inc.; Castle Creek Biosciences, Inc.; Intrexon Energy Partners, LLC; and Intrexon Energy Partners II, LLC. The company was formerly known as Intrexon Corporation and changed its name to Precigen, Inc. in January 2020. Precigen, Inc. was founded in 1998 and is based in Germantown, Maryland.

AI Analysis | Feedback

  • Like CRISPR Therapeutics, but with a broader set of advanced genetic and cellular engineering platforms for diverse next-generation therapies.
  • Imagine Moderna developing cutting-edge therapies, but Precigen focuses on building and utilizing a diverse suite of genetic and cellular engineering platforms to create a wider range of next-generation treatments.

AI Analysis | Feedback

Precigen (PGEN) Major Products and Platforms

  • Gene and Cellular Therapies: Precigen discovers and develops advanced treatments by engineering genes and cells.
  • Disease-Modifying Therapeutics: These therapies are designed to alter the progression of various diseases.
  • Genetically Engineered Swine: The company provides swine specifically modified for regenerative medicine applications.
  • UltraVector Platform: This technology platform designs and assembles complex gene expression programs using advanced DNA construction.
  • UltraCAR-T Platform: A specialized platform for developing CAR-T cell therapies to treat cancer.
  • AdenoVerse Platform: This platform utilizes a library of engineered adenovectors for gene delivery and immunotherapy.
  • ActoBiotics Platform: A platform employing genetically modified bacteria to deliver therapeutic proteins and peptides at mucosal sites.
  • Sleeping Beauty System: A non-viral transposon/transposase system used for efficient gene delivery and engineering.
  • RheoSwitch System: An inducible gene switch system enabling precise, dose-proportionate control over gene expression.
  • Kill Switches: Engineered genetic mechanisms designed to selectively eliminate cell therapies in vivo for enhanced safety.

AI Analysis | Feedback

Precigen (PGEN) primarily sells its technologies, platforms, and services to other companies in the biotechnology, pharmaceutical, and research sectors through collaboration and license agreements.

Based on the provided description, its major customers and partners include:

  • Alaunos Therapeutics, Inc. (Symbol: TCRT)
  • Ares Trading S.A. (Not publicly traded as a standalone entity)
  • Oragenics, Inc. (Symbol: OGEN)
  • Castle Creek Biosciences, Inc. (Private company)
  • Intrexon Energy Partners, LLC (Private company)
  • Intrexon Energy Partners II, LLC (Private company)

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Helen Sabzevari, PhD – President, Chief Executive Officer, and Director

Dr. Helen Sabzevari was appointed CEO of Precigen in January 2020. She has dedicated her career to eradicating disease, contributing to the development of multiple therapeutics for various cancers, autoimmune disorders, and infectious diseases. Dr. Sabzevari cofounded Compass Therapeutics in 2015, serving as its Chief Scientific Officer until 2017. Prior to Precigen, she held executive leadership positions at Merck KGaA, where she helped bring forth Bavencio, an anti-PD-L1 checkpoint inhibitor, and the National Institutes of Health (NIH), where she led the Molecular Immunology Group at the Laboratory of Tumor Immunology and Biology. She holds a doctorate in cell and molecular immunology and received the National Institutes of Health (NIH) merit award for her work in immuno-oncology.

Harry Thomasian, Jr. – Chief Financial Officer and Principal Accounting Officer

Mr. Harry Thomasian, Jr. is a global finance leader with over 35 years of international business experience. His expertise encompasses equity and debt financings, P&L management, business operations, regulatory compliance, generally accepted accounting principles, SEC filings, and Sarbanes-Oxley compliance. Before joining Precigen, Mr. Thomasian was with EY (formerly Ernst & Young LLP), a global professional services firm, where he served as a Senior Client Services Partner, the Baltimore Office Growth Markets Leader for the life sciences industry, and a Senior Partner in EY's Capital Markets Center in Tokyo. He is a licensed certified public accountant in multiple states and jurisdictions.

Rutul R. Shah – Chief Operating Officer

Mr. Rutul R. Shah was named Chief Operating Officer in September 2021.

Donald P. Lehr – Chief Legal Officer

Mr. Donald P. Lehr possesses extensive experience in corporate, securities, and general business law. Before his tenure at Intrexon (now Precigen), he worked at Hogan Lovells LLP, where his practice involved representing privately and publicly held corporations across diverse sectors, including biotechnology, pharmaceuticals, healthcare, software, technology, and manufacturing. He also served as a judicial clerk for the Honorable Irma S. Raker of the Court of Appeals of Maryland.

Phil Tennant – Chief Commercial Officer

Mr. Phil Tennant's current focus is on the commercial launch of Papzimeos, which received approval in August 2025.

AI Analysis | Feedback

The key risks to Precigen's business, which trades under the symbol PGEN, revolve around its financial stability, the commercial success of its recently approved gene therapy, and the progress of its broader development pipeline.

  1. Financial Stability and Cash Burn: Precigen has consistently incurred significant net losses and has been "quickly burning through cash." While the company secured up to $125 million in non-dilutive financing in September 2025, and management aims for cash flow breakeven by late 2026 or early 2027, the substantial operating expenses associated with commercializing its first product raise concerns about its ability to maintain a sufficient cash runway. The company has a notably high debt-to-equity ratio.
  2. Single Asset Dependency and Commercialization Risk of PAPZIMEOS: Precigen's investment narrative is heavily reliant on the successful commercial launch and market uptake of PAPZIMEOS (formerly PRGN-2012), its first and currently only FDA-approved therapy for adult recurrent respiratory papillomatosis (RRP). Risks include potential payer pushback on pricing and reimbursement, slower-than-expected patient uptake, and competition from existing off-label drugs and investigational assets, such as INO-3107. A failure to meet revenue expectations for PAPZIMEOS could severely impact the company's financial outlook and its ability to achieve cash flow breakeven.
  3. Clinical Trial Setbacks and Pipeline Risk: Although PAPZIMEOS has achieved approval, the long-term value and growth of Precigen are tied to the continued advancement and success of its broader gene and cell therapy pipeline, including its UltraCAR-T and AdenoVerse programs. The company has recently prioritized the development of PAPZIMEOS, leading to the pausing of other UltraCAR-T clinical programs and all preclinical programs, as well as the shutdown of its ActoBio subsidiary. Any delays or negative data from ongoing or future clinical trials for these remaining pipeline assets could significantly impact the company's stock value and future prospects.

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Precigen (PGEN) operates in several significant addressable markets with its gene and cellular therapies.

UltraCAR-T Platform (for cancer treatment)

The global CAR T-cell therapy market, which includes Precigen's UltraCAR-T platform for cancer treatment, was estimated to be between approximately USD 4.20 billion and USD 20.54 billion in 2025. This market is projected to grow significantly, potentially reaching between USD 9.95 billion by 2030 and USD 268.0 billion by 2035.

AdenoVerse Immunotherapy (e.g., PAPZIMEOS for Recurrent Respiratory Papillomatosis - RRP)

For its AdenoVerse Immunotherapy platform, particularly for PAPZIMEOS in Recurrent Respiratory Papillomatosis (RRP), the estimated addressable patient population in the U.S. is approximately 27,000 adults. More broadly, the global oncolytic virus therapy market, of which AdenoVerse immunotherapy is a part, has varying estimates. One report valued the global oncolytic virus therapy market size at USD 411.4 million in 2024, projected to grow to USD 3.22 billion by 2033. Another source estimated the global oncolytic adenovirus market to be valued at USD 140.2 billion in 2025, projected to reach USD 288.9 billion by 2035.

ActoBiotics Platform (genetically modified bacteria for mucosal sites, e.g., Type 1 Diabetes)

Precigen's ActoBiotics platform, which delivers proteins and peptides at mucosal sites, falls within the oral transmucosal drugs and transmucosal drug delivery devices markets. The global oral transmucosal drugs market was valued at approximately USD 36.72 billion in 2024 and is expected to reach around USD 70.37 billion by 2034. Another estimate places the global oral transmucosal drugs market size at USD 45.82 billion in 2025, projected to reach USD 96.8 billion by 2033. The global transmucosal drug delivery devices market was valued at approximately USD 46.63 billion in 2024 and is predicted to grow to around USD 86.64 billion by 2034.

Genetically Engineered Swine (for regenerative medicine/xenotransplantation)

The market for genetically engineered swine for regenerative medicine applications, including xenotransplantation, is also substantial. The global xenotransplantation market was valued at approximately USD 14.68 billion in 2024, growing to USD 15.82 billion in 2025. Other estimates place the global market value at USD 47.9 billion in 2024, projected to reach USD 109.7 billion by 2034, or from USD 3.12 billion in 2025 to around USD 7.26 billion by 2034. The U.S. xenotransplantation market was valued at USD 13.8 billion in 2024 and is forecasted to reach USD 32.7 billion by 2034.

AI Analysis | Feedback

Precigen (PGEN) is expected to experience significant revenue growth over the next two to three years, primarily driven by the following factors:

  1. Commercialization and Market Penetration of PAPZIMEOS for Adult Recurrent Respiratory Papillomatosis (RRP): The commercial launch and rapid adoption of PAPZIMEOS (zopapogene imadenovec) for adult RRP, following its full FDA approval in August 2025, is a primary driver of near-term revenue. Increased patient uptake, broad insurer coverage (including Medicare and Medicaid), and its endorsement as a first-line therapy are expected to contribute to accelerated sales.
  2. Geographic Expansion and New Indications for PAPZIMEOS: Beyond the current adult RRP market in the US, future revenue growth is anticipated from the ongoing geographic expansion of PAPZIMEOS, including submissions to regulatory bodies like the European Medicines Agency (EMA), and the initiation of pediatric clinical trials to address younger patient populations with RRP.
  3. Advancement of the Gene and Cell Therapy Pipeline: Precigen's robust pipeline of differentiated gene and cell therapies across immuno-oncology, autoimmune disorders, and infectious diseases, leveraging proprietary platforms such as UltraCAR-T and AdenoVerse, is expected to provide long-term revenue optionality as these programs progress through clinical development towards potential commercialization.

AI Analysis | Feedback

Share Issuance

  • Precigen experienced a substantial increase in its outstanding shares, growing from approximately 206.74 million at the end of 2021 to 307.17 million by February 2026.
  • In 2024, the net issuance of preferred shares amounted to $79.0 million.
  • The conversion of Series A Convertible Perpetual Preferred Stock into common stock has also contributed to share issuance.

Inbound Investments

  • In September 2025, Precigen secured a non-dilutive credit facility of up to $125 million with investment funds managed by Pharmakon Advisors, LP.
  • The initial tranche of $100 million from this credit facility was funded at closing.
  • An additional $25 million from the credit facility can be drawn at Precigen's discretion through March 31, 2027.

Capital Expenditures

  • Capital expenditures for Precigen were approximately $0.389 million in Q3 2025.
  • Over the last 12 months, Precigen's capital expenditures totaled approximately $3.01 million.
  • These capital investments are focused on long-term sustainable strategies, likely including innovative research and development efforts.

Better Bets vs. Precigen (PGEN)

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Recent Active Movers

Peer Comparisons

Peers to compare with:

Financials

PGENCRSPNTLAEDITIOVANKTXMedian
NamePrecigen CRISPR T.Intellia.Editas M.Iovance .Nkarta  
Mkt Price3.8947.5513.242.323.692.143.79
Mkt Cap1.44.51.50.21.50.21.4
Rev LTM1006841264025
Op Inc LTM-107-665-441-99-398-122-260
FCF LTM-90-371-396-166-336-90-251
FCF 3Y Avg-78-263-386-174-361-103-218
CFO LTM-88-345-395-165-302-89-234
CFO 3Y Avg-74-249-379-169-339-92-209

Growth & Margins

PGENCRSPNTLAEDITIOVANKTXMedian
NamePrecigen CRISPR T.Intellia.Editas M.Iovance .Nkarta  
Rev Chg LTM146.7%-100.0%16.9%25.4%60.6%-25.4%
Rev Chg 3Y Avg11.0%28,190.6%15.4%87.7%--51.5%
Rev Chg Q283.6%-100.0%78.8%-19.2%17.7%-17.7%
QoQ Delta Rev Chg LTM53.5%-100.0%17.6%-12.6%5.2%-5.2%
Op Mgn LTM-1,100.8%--651.7%-245.2%-151.1%--448.4%
Op Mgn 3Y Avg-1,647.4%--998.4%-400.4%-13,042.3%--1,322.9%
QoQ Delta Op Mgn LTM605.8%-180.5%12.9%13.1%-96.8%
CFO/Rev LTM-907.0%--583.3%-407.8%-114.8%--495.6%
CFO/Rev 3Y Avg-1,239.7%--757.5%-409.3%-10,253.5%--998.6%
FCF/Rev LTM-927.6%--585.0%-409.3%-127.6%--497.1%
FCF/Rev 3Y Avg-1,327.7%--774.2%-420.9%-10,884.9%--1,051.0%

Valuation

PGENCRSPNTLAEDITIOVANKTXMedian
NamePrecigen CRISPR T.Intellia.Editas M.Iovance .Nkarta  
Mkt Cap1.44.51.50.21.50.21.4
P/S142.3-22.75.65.7-14.2
P/EBIT-5.6-6.8-3.5-1.5-3.8-1.3-3.6
P/E-5.5-7.8-3.7-1.4-3.8-1.5-3.8
P/CFO-15.7-13.1-3.9-1.4-5.0-1.8-4.4
Total Yield-18.2%-12.8%-26.9%-70.9%-26.0%-65.7%-26.4%
Dividend Yield0.0%0.0%0.0%0.0%0.0%0.0%0.0%
FCF Yield 3Y Avg-16.7%-5.7%-27.5%-102.8%-21.6%-52.6%-24.6%
D/E0.10.00.10.10.00.50.1
Net D/E0.0-0.4-0.2-0.6-0.2-1.3-0.3

Returns

PGENCRSPNTLAEDITIOVANKTXMedian
NamePrecigen CRISPR T.Intellia.Editas M.Iovance .Nkarta  
1M Rtn-2.3%-16.2%-2.5%10.0%-2.4%-14.7%-2.4%
3M Rtn-7.2%-16.2%38.1%5.0%28.6%18.2%11.6%
6M Rtn11.6%-21.2%-20.3%-28.2%82.7%7.0%-6.6%
12M Rtn141.6%21.4%59.3%82.7%7.3%56.2%57.8%
3Y Rtn342.8%7.2%-64.4%-68.9%-40.0%-38.7%-39.3%
1M Excs Rtn8.1%-7.1%5.4%15.7%3.1%-10.6%4.3%
3M Excs Rtn1.8%-9.5%46.8%12.2%37.1%25.2%18.7%
6M Excs Rtn3.2%-19.7%-23.0%-28.7%76.5%6.3%-8.2%
12M Excs Rtn115.4%4.2%39.5%66.3%-6.1%37.5%38.5%
3Y Excs Rtn195.1%-56.3%-128.5%-133.0%-103.1%-101.0%-102.1%

Comparison Analyses

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Financials

Segment Financials

Revenue by Segment
$ Mil20252024202320222021
Exemplar6121310 
Biopharmaceuticals015122 
Trans Ova   7170
ActoBio    0
Elimination of intersegment revenues    -15
Human Biotherapeutics    4
Other revenues, including from other operating segments    18
PGEN Therapeutics    14
Total6271410391


Price Behavior

Price Behavior
Market Price$3.89 
Market Cap ($ Bil)1.2 
First Trading Date08/08/2013 
Distance from 52W High-25.3% 
   50 Days200 Days
DMA Price$4.08$3.44
DMA Trendupdown
Distance from DMA-4.7%13.0%
 3M1YR
Volatility90.4%107.1%
Downside Capture86.7936.10
Upside Capture76.78124.54
Correlation (SPY)28.4%31.7%
PGEN Betas & Captures as of 2/28/2026

 1M2M3M6M1Y3Y
Beta1.971.401.081.091.701.81
Up Beta-2.630.400.610.841.992.05
Down Beta4.922.051.422.402.441.42
Up Capture146%64%98%23%149%1202%
Bmk +ve Days9203170142431
Stock +ve Days8162954113348
Down Capture313%194%107%90%69%111%
Bmk -ve Days12213054109320
Stock -ve Days13253169130366

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with PGEN
PGEN131.1%107.3%1.23-
Sector ETF (XLV)1.7%17.6%-0.0630.6%
Equity (SPY)13.1%18.9%0.5228.3%
Gold (GLD)45.0%27.5%1.34-9.2%
Commodities (DBC)17.7%17.5%0.844.0%
Real Estate (VNQ)1.7%16.4%-0.0729.4%
Bitcoin (BTCUSD)-18.7%43.9%-0.3512.9%

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Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with PGEN
PGEN-13.6%87.7%0.21-
Sector ETF (XLV)6.5%14.5%0.2726.5%
Equity (SPY)12.0%17.0%0.5533.5%
Gold (GLD)19.8%17.6%0.921.0%
Commodities (DBC)11.6%18.9%0.502.4%
Real Estate (VNQ)3.4%18.8%0.0931.6%
Bitcoin (BTCUSD)4.1%56.7%0.2917.5%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with PGEN
PGEN-19.7%91.4%0.16-
Sector ETF (XLV)10.1%16.5%0.5028.7%
Equity (SPY)14.0%17.9%0.6732.2%
Gold (GLD)12.9%15.8%0.671.7%
Commodities (DBC)8.2%17.6%0.3910.7%
Real Estate (VNQ)4.7%20.7%0.1925.5%
Bitcoin (BTCUSD)67.1%66.8%1.0612.4%

Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date3132026
Short Interest: Shares Quantity39.8 Mil
Short Interest: % Change Since 2282026-5.0%
Average Daily Volume3.8 Mil
Days-to-Cover Short Interest10.6 days
Basic Shares Quantity354.3 Mil
Short % of Basic Shares11.2%

Earnings Returns History

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 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
3/25/202625.5%  
11/13/202525.6%1.0%0.3%
3/19/20250.6%-10.1%-22.3%
11/14/2024-7.1%2.3%-23.7%
8/6/2024-12.6%-19.3%-29.0%
3/19/20240.0%-2.8%-8.3%
11/9/2023-13.5%-8.7%-7.9%
8/9/20236.9%31.9%38.8%
...
SUMMARY STATS   
# Positive1199
# Negative101111
Median Positive7.9%7.5%12.2%
Median Negative-8.6%-10.2%-17.9%
Max Positive25.6%31.9%71.1%
Max Negative-24.7%-39.0%-45.2%

SEC Filings

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Report DateFiling DateFiling
12/31/202503/25/202610-K
09/30/202511/13/202510-Q
06/30/202508/12/202510-Q
03/31/202505/14/202510-Q
12/31/202403/19/202510-K
09/30/202411/14/202410-Q
06/30/202408/14/202410-Q
03/31/202405/14/202410-Q
12/31/202303/19/202410-K
09/30/202311/09/202310-Q
06/30/202308/09/202310-Q
03/31/202305/10/202310-Q
12/31/202203/06/202310-K
09/30/202211/09/202210-Q
06/30/202208/08/202210-Q
03/31/202205/09/202210-Q

Insider Activity

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#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Kirk, Randal Jby R.J. Kirk DOTSell122220254.18555,1192,320,397341,128,329Form
2Kirk, Randal Jby JPK 2008Sell122220254.1812,90953,9601,995,917Form
3Kirk, Randal Jby JPK 2009Sell122220254.1894,341394,34515,085,858Form
4Kirk, Randal Jby JPK 2012Sell122220254.1838,729161,8876,753,350Form
5Kirk, Randal Jby MGK 2008Sell122220254.1812,90953,9601,991,891Form