Tearsheet

LakeShore Biopharma (LSB)


Market Price (9/30/2025): $0.4919 | Market Cap: $4.6 Mil
Sector: Health Care | Industry: Biotechnology

LakeShore Biopharma (LSB)


Market Price (9/30/2025): $0.4919
Market Cap: $4.6 Mil
Sector: Health Care
Industry: Biotechnology

Investment Highlights

0   Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -164 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -24%
1   Debt is significant
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is 5020%
2   Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -3171%
0 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -164 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -24%
1 Debt is significant
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is 5020%
2 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -3171%

Market Valuation

 9/30/25202420232022
Share Price CYE$0.49$3.46$5.11 
Market Cap CYE ($ Mil)4.632.247.6-
Total Debt ($ Mil)554.2414.4424.5498.6
Total Cash ($ Mil)259.928.1246.4370.1
Enterprise Value ($ Mil)298.9446.6472.1 
Valuation Ratios    
P/S TTM0.00.10.10.0
P/EBIT TTM-0.0-0.8-0.10.0
P/E TTM-0.0-0.7-0.10.0
Sector Ratios    
P/S TTM (Sector)3.73.64.04.5
P/EBIT TTM (Sector)-1.6-1.3-1.4-1.3
P/E TTM (Sector)-1.9-1.5-1.5-1.3
 9/30/252024
Share Price CYE$0.49$3.46
Market Cap CYE ($ Mil)4.632.2
Total Debt ($ Mil)554.2414.4
Total Cash ($ Mil)259.928.1
Enterprise Value ($ Mil)298.9446.6
Valuation Ratios  
P/S TTM0.00.1
P/EBIT TTM-0.0-0.8
P/E TTM-0.0-0.7
Sector Ratios  
P/S TTM (Sector)3.73.6
P/EBIT TTM (Sector)-1.6-1.3
P/E TTM (Sector)-1.9-1.5

Business Description

LakeShore Biopharma Co., Ltd, a biopharmaceutical company, engages in discovering, developing, manufacturing, and commercializing of vaccines and therapeutic biologics for infectious diseases and cancer. The company develops a proprietary PIKA immunomodulating technology platform and a series of product targeting PIKA rabies vaccine, PIKA recombinant COVID-19 vaccine, and PIKA YS-ON-001. It operates in China, the United States, Singapore, the United Arab Emirates, and the Philippines. Show more

Price Returns Compared

Expand for Detailed View

 202020212022202320242025Total [1]
Returns
LSB Return-----32%-82%-88%
Peers Return75%-16%-34%-21%-51%47%-45%
S&P 500 Return16%27%-19%24%23%13%106%

[1] Cumulative total returns since the beginning of 2020
[2] Peers: VRTX, EDIT, INFIQ, SRNE, STA.
[3] 2025 data is for the year up to 9/29/2025 (YTD)

Better Bets than LakeShore Biopharma (LSB)

Trade Ideas

Select past trade ideas related to LSB and Biotechnology.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
LNTH_8312025_Dip_Buyer_High_CFO_Margins_ExInd_DE08312025LNTHLantheusDip BuyDB | CFO/Rev | Low D/EDip Buy with High Cash Flow Margins
Buying dips for companies with significant cash flows from operations and reasonable debt / market cap
-7.8%-7.8%-8.7%
COO_8312025_Monopoly_xInd_xCD_Getting_Cheaper08312025COOCooper CompaniesMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
0.2%0.2%-4.6%
WST_8312025_Monopoly_xInd_xCD_Getting_Cheaper08312025WSTWest Pharmaceutical ServicesMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
5.9%5.9%-1.3%
BMY_7312025_Dip_Buyer_FCFYield07312025BMYBristol-Myers SquibbDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
1.9%1.9%0.0%
UTHR_7312025_Dip_Buyer_FCFYield07312025UTHRUnited TherapeuticsDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
57.5%57.5%0.0%
Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
LNTH_8312025_Dip_Buyer_High_CFO_Margins_ExInd_DE08312025LNTHLantheusDip BuyDB | CFO/Rev | Low D/EDip Buy with High Cash Flow Margins
Buying dips for companies with significant cash flows from operations and reasonable debt / market cap
-7.8%-7.8%-8.7%
COO_8312025_Monopoly_xInd_xCD_Getting_Cheaper08312025COOCooper CompaniesMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
0.2%0.2%-4.6%
WST_8312025_Monopoly_xInd_xCD_Getting_Cheaper08312025WSTWest Pharmaceutical ServicesMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
5.9%5.9%-1.3%
BMY_7312025_Dip_Buyer_FCFYield07312025BMYBristol-Myers SquibbDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
1.9%1.9%0.0%
UTHR_7312025_Dip_Buyer_FCFYield07312025UTHRUnited TherapeuticsDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
57.5%57.5%0.0%

See Trefis Trade Ideas for more.

Recent Active Movers

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Peer Comparisons for LakeShore Biopharma

Financials

LSBVRTXEDITINFIQSRNESTAMedian
NameLakeShor.Vertex P.Editas M.Infinity.Sorrento.Starton . 
Mkt Price-395.313.52---199.41
Mkt Cap0.0101.50.3---0.3
Rev LTM67311,41939--0356
Op Inc LTM-164-199-161---11-162
FCF LTM-3,500-205---1,647
FCF 3Y Avg-1,984-182---901
CFO LTM-3,846-201---1,823
CFO 3Y Avg-2,324-177---1,073

Growth & Margins

LSBVRTXEDITINFIQSRNESTAMedian
NameLakeShor.Vertex P.Editas M.Infinity.Sorrento.Starton . 
Rev Chg LTM-10.5%-42.0%----15.8%
Rev Chg 3Y Avg-11.0%55.3%---33.1%
Rev Chg Q-12.1%597.5%---304.8%
QoQ Delta Rev Chg LTM-2.9%8.6%---5.7%
Op Mgn LTM-24.4%-1.7%-413.4%----24.4%
Op Mgn 3Y Avg-26.5%-616.5%----295.0%
QoQ Delta Op Mgn LTM-2.0%164.9%---83.5%
CFO/Rev LTM-33.7%-517.6%----242.0%
CFO/Rev 3Y Avg-22.5%-538.7%----258.1%
FCF/Rev LTM-30.6%-526.8%----248.1%
FCF/Rev 3Y Avg-19.2%-552.8%----266.8%

Valuation

LSBVRTXEDITINFIQSRNESTAMedian
NameLakeShor.Vertex P.Editas M.Infinity.Sorrento.Starton . 
Mkt Cap0.0101.50.3---0.3
P/S0.08.97.6---7.6
P/EBIT-0.023.1-1.3----0.0
P/E-0.027.9-1.3----0.0
P/CFO-26.4-1.5---12.5
Total Yield-3,166.6%3.6%-79.7%----79.7%
Dividend Yield0.0%0.0%0.0%---0.0%
FCF Yield 3Y Avg-2.1%-61.3%----29.6%
D/E94.50.00.1---0.1
Net D/E50.2-0.0-0.5----0.0

Returns

LSBVRTXEDITINFIQSRNESTAMedian
NameLakeShor.Vertex P.Editas M.Infinity.Sorrento.Starton . 
1M Rtn-1.1%37.0%---19.0%
3M Rtn--11.2%60.0%---24.4%
6M Rtn--18.5%203.4%---92.5%
12M Rtn--14.6%1.1%----6.7%
3Y Rtn-36.5%-71.2%----17.4%
1M Excs Rtn--1.6%30.4%---14.4%
3M Excs Rtn--18.6%52.6%---17.0%
6M Excs Rtn--39.1%162.2%---61.6%
12M Excs Rtn--30.8%-12.6%----21.7%
3Y Excs Rtn--39.2%-150.7%----95.0%

Financials

Price Behavior

Short Interest

Short Interest: As Of Date9152025
Short Interest: Shares Quantity17,978
Short Interest: % Change Since 8312025-51.4%
Average Daily Volume35,792
Days-to-Cover Short Interest1
Basic Shares Quantity9,305,819
Short % of Basic Shares0.2%

SEC Filings

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Report DateFiling DateFiling
3312025731202520-F 3/31/2025
9302024121920246-K 9/30/2024
3312024815202420-F 3/31/2024
930202312220246-K 9/30/2023
630202381620236-K 6/30/2023
33120238152023424B3 3/31/2023
33120222082023424B3 3/31/2022

Insider Activity

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