LakeShore Biopharma (LSB)
Market Price (9/30/2025): $0.4919 | Market Cap: $4.6 MilSector: Health Care | Industry: Biotechnology
LakeShore Biopharma (LSB)
Market Price (9/30/2025): $0.4919Market Cap: $4.6 MilSector: Health CareIndustry: Biotechnology
Investment Highlights
| Not profitable at operating income levelOp Inc LTMOperating Income, Last Twelve Months is -164 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -24% | ||
| Debt is significantNet D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is 5020% | ||
| Yield minus risk free rate is negativeERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -3171% |
| Not profitable at operating income levelOp Inc LTMOperating Income, Last Twelve Months is -164 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -24% |
| Debt is significantNet D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is 5020% |
| Yield minus risk free rate is negativeERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -3171% |
Market Valuation
| 9/30/25 | 2024 | 2023 | 2022 | |
|---|---|---|---|---|
| Share Price CYE | $0.49 | $3.46 | $5.11 | |
| Market Cap CYE ($ Mil) | 4.6 | 32.2 | 47.6 | - |
| Total Debt ($ Mil) | 554.2 | 414.4 | 424.5 | 498.6 |
| Total Cash ($ Mil) | 259.9 | 28.1 | 246.4 | 370.1 |
| Enterprise Value ($ Mil) | 298.9 | 446.6 | 472.1 | |
| Valuation Ratios | ||||
| P/S TTM | 0.0 | 0.1 | 0.1 | 0.0 |
| P/EBIT TTM | -0.0 | -0.8 | -0.1 | 0.0 |
| P/E TTM | -0.0 | -0.7 | -0.1 | 0.0 |
| Sector Ratios | ||||
| P/S TTM (Sector) | 3.7 | 3.6 | 4.0 | 4.5 |
| P/EBIT TTM (Sector) | -1.6 | -1.3 | -1.4 | -1.3 |
| P/E TTM (Sector) | -1.9 | -1.5 | -1.5 | -1.3 |
| 9/30/25 | 2024 | |
|---|---|---|
| Share Price CYE | $0.49 | $3.46 |
| Market Cap CYE ($ Mil) | 4.6 | 32.2 |
| Total Debt ($ Mil) | 554.2 | 414.4 |
| Total Cash ($ Mil) | 259.9 | 28.1 |
| Enterprise Value ($ Mil) | 298.9 | 446.6 |
| Valuation Ratios | ||
| P/S TTM | 0.0 | 0.1 |
| P/EBIT TTM | -0.0 | -0.8 |
| P/E TTM | -0.0 | -0.7 |
| Sector Ratios | ||
| P/S TTM (Sector) | 3.7 | 3.6 |
| P/EBIT TTM (Sector) | -1.6 | -1.3 |
| P/E TTM (Sector) | -1.9 | -1.5 |
Business Description
LakeShore Biopharma Co., Ltd, a biopharmaceutical company, engages in discovering, developing, manufacturing, and commercializing of vaccines and therapeutic biologics for infectious diseases and cancer. The company develops a proprietary PIKA immunomodulating technology platform and a series of product targeting PIKA rabies vaccine, PIKA recombinant COVID-19 vaccine, and PIKA YS-ON-001. It operates in China, the United States, Singapore, the United Arab Emirates, and the Philippines.
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Price Returns Compared
Expand for Detailed View| 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total [1] | |
|---|---|---|---|---|---|---|---|
| Returns | |||||||
| LSB Return | - | - | - | - | -32% | -82% | -88% |
| Peers Return | 75% | -16% | -34% | -21% | -51% | 47% | -45% |
| S&P 500 Return | 16% | 27% | -19% | 24% | 23% | 13% | 106% |
[1] Cumulative total returns since the beginning of 2020
[2] Peers: VRTX, EDIT, INFIQ, SRNE, STA.
[3] 2025 data is for the year up to 9/29/2025 (YTD)
Trade Ideas
Select past trade ideas related to LSB and Biotechnology.
| Date | Ticker | Company | Category | Trade Strategy | 6M Fwd Rtn | 12M Fwd Rtn | 12M Max DD |
|---|---|---|---|---|---|---|---|
| 08312025 | LNTH | Lantheus | Dip Buy | DB | CFO/Rev | Low D/EDip Buy with High Cash Flow MarginsBuying dips for companies with significant cash flows from operations and reasonable debt / market cap | -7.8% | -7.8% | -8.7% |
| 08312025 | COO | Cooper Companies | Monopoly | MY | Getting CheaperMonopoly-Like with P/S DeclineLarge cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple | 0.2% | 0.2% | -4.6% |
| 08312025 | WST | West Pharmaceutical Services | Monopoly | MY | Getting CheaperMonopoly-Like with P/S DeclineLarge cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple | 5.9% | 5.9% | -1.3% |
| 07312025 | BMY | Bristol-Myers Squibb | Dip Buy | DB | FCFY OPMDip Buy with High FCF Yield and High MarginBuying dips for companies with high FCF yield and meaningfully high operating margin | 1.9% | 1.9% | 0.0% |
| 07312025 | UTHR | United Therapeutics | Dip Buy | DB | FCFY OPMDip Buy with High FCF Yield and High MarginBuying dips for companies with high FCF yield and meaningfully high operating margin | 57.5% | 57.5% | 0.0% |
| Date | Ticker | Company | Category | Trade Strategy | 6M Fwd Rtn | 12M Fwd Rtn | 12M Max DD |
|---|---|---|---|---|---|---|---|
| 08312025 | LNTH | Lantheus | Dip Buy | DB | CFO/Rev | Low D/EDip Buy with High Cash Flow MarginsBuying dips for companies with significant cash flows from operations and reasonable debt / market cap | -7.8% | -7.8% | -8.7% |
| 08312025 | COO | Cooper Companies | Monopoly | MY | Getting CheaperMonopoly-Like with P/S DeclineLarge cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple | 0.2% | 0.2% | -4.6% |
| 08312025 | WST | West Pharmaceutical Services | Monopoly | MY | Getting CheaperMonopoly-Like with P/S DeclineLarge cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple | 5.9% | 5.9% | -1.3% |
| 07312025 | BMY | Bristol-Myers Squibb | Dip Buy | DB | FCFY OPMDip Buy with High FCF Yield and High MarginBuying dips for companies with high FCF yield and meaningfully high operating margin | 1.9% | 1.9% | 0.0% |
| 07312025 | UTHR | United Therapeutics | Dip Buy | DB | FCFY OPMDip Buy with High FCF Yield and High MarginBuying dips for companies with high FCF yield and meaningfully high operating margin | 57.5% | 57.5% | 0.0% |
See Trefis Trade Ideas for more.
Research & Analysis
Invest in Strategies
Wealth Management
Peer Comparisons for LakeShore Biopharma
Financials
| Median | |
|---|---|
| Name | |
| Mkt Price | 199.41 |
| Mkt Cap | 0.3 |
| Rev LTM | 356 |
| Op Inc LTM | -162 |
| FCF LTM | 1,647 |
| FCF 3Y Avg | 901 |
| CFO LTM | 1,823 |
| CFO 3Y Avg | 1,073 |
Growth & Margins
| Median | |
|---|---|
| Name | |
| Rev Chg LTM | -15.8% |
| Rev Chg 3Y Avg | 33.1% |
| Rev Chg Q | 304.8% |
| QoQ Delta Rev Chg LTM | 5.7% |
| Op Mgn LTM | -24.4% |
| Op Mgn 3Y Avg | -295.0% |
| QoQ Delta Op Mgn LTM | 83.5% |
| CFO/Rev LTM | -242.0% |
| CFO/Rev 3Y Avg | -258.1% |
| FCF/Rev LTM | -248.1% |
| FCF/Rev 3Y Avg | -266.8% |
Valuation
| Median | |
|---|---|
| Name | |
| Mkt Cap | 0.3 |
| P/S | 7.6 |
| P/EBIT | -0.0 |
| P/E | -0.0 |
| P/CFO | 12.5 |
| Total Yield | -79.7% |
| Dividend Yield | 0.0% |
| FCF Yield 3Y Avg | -29.6% |
| D/E | 0.1 |
| Net D/E | -0.0 |
Returns
| Median | |
|---|---|
| Name | |
| 1M Rtn | 19.0% |
| 3M Rtn | 24.4% |
| 6M Rtn | 92.5% |
| 12M Rtn | -6.7% |
| 3Y Rtn | -17.4% |
| 1M Excs Rtn | 14.4% |
| 3M Excs Rtn | 17.0% |
| 6M Excs Rtn | 61.6% |
| 12M Excs Rtn | -21.7% |
| 3Y Excs Rtn | -95.0% |
SEC Filings
Expand for More| Report Date | Filing Date | Filing |
|---|---|---|
| 3312025 | 7312025 | 20-F 3/31/2025 |
| 9302024 | 12192024 | 6-K 9/30/2024 |
| 3312024 | 8152024 | 20-F 3/31/2024 |
| 9302023 | 1222024 | 6-K 9/30/2023 |
| 6302023 | 8162023 | 6-K 6/30/2023 |
| 3312023 | 8152023 | 424B3 3/31/2023 |
| 3312022 | 2082023 | 424B3 3/31/2022 |
Industry Resources
External Quote Links
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| TradingView | Morningstar |
| SeekingAlpha | ValueLine |
| Motley Fool | Robinhood |
| CNBC | Etrade |
| MarketWatch | Unusual Whales |
| YCharts | Perplexity Finance |
| FinViz |