iShares Biotechnology ETF (IBB)
Market Price (5/22/2026): $169.06
iShares Biotechnology ETF (IBB)
Market Price (5/22/2026): $169.06
Asset Allocation with IBB
Valuation & Yield
| 5/22/26 | 2025 | 2024 | 2023 | 2022 | 2021 | |
|---|---|---|---|---|---|---|
| Share Price CYE | $169.06 | $168.77 | $131.87 | $135.13 | $130.23 | $150.89 |
| Dividend/Share TTM | $0.27 | $0.39 | $0.39 | $0.35 | $0.41 | $0.32 |
Valuation [1] | ||||||
| P/S TTM | 6.25 | 6.38 | 5.62 | 6.25 | 5.96 | 7.46 |
| P/E TTM | 33.29 | 33.38 | 46.62 | 35.74 | 26.17 | 25.81 |
Yields TTM | ||||||
| Earnings Yield | 3.00% | 3.00% | 2.15% | 2.80% | 3.82% | 3.88% |
| Dividend Yield | 0.16% | 0.23% | 0.29% | 0.26% | 0.31% | 0.21% |
| Total Yield (TY) | 3.16% | 3.22% | 2.44% | 3.06% | 4.13% | 4.09% |
Risk Premium [2] | ||||||
| Risk Free Rate (Rf) | 4.57% | 4.18% | 4.58% | 3.88% | 3.88% | 1.52% |
| Risk Prem. (TY - Rf) | -1.41% | -0.96% | -2.14% | -0.82% | 0.25% | 2.57% |
[1] P/E uses aggregate method (profitable constituents only); P/S uses all constituents. Ratios reflect current ETF holdings at current weights.
[2] The premium above the risk free rate (US 10Y) offered by the investment. Negative premiums can indicate stretched valuations.
Top 20 Holdings for IBB
Total Weights Top 5: 31.9% | Top 10: 45.2% | Top 20: 61.3%
| Ticker | Holding | Weight |
|---|---|---|
| GILD | Gilead Sciences | 7.44% |
| VRTX | Vertex Pharmaceuticals | 7.35% |
| AMGN | Amgen | 7.25% |
| REGN | Regeneron Pharmaceuticals | 6.21% |
| ALNY | Alnylam Pharmaceuticals | 3.69% |
| ARGX | argenx | 3.46% |
| BIIB | Biogen | 2.58% |
| NTRA | Natera | 2.53% |
| RVMD | Revolution Medicines | 2.43% |
| UTHR | United Therapeutics | 2.24% |
| INSM | Insmed | 2.16% |
| ONC | BeOne Medicines | 2.06% |
| ILMN | Illumina | 1.98% |
| INCY | Incyte | 1.80% |
| MRNA | Moderna | 1.63% |
| ROIV | Roivant Sciences | 1.49% |
| NBIX | Neurocrine Biosciences | 1.42% |
| GMAB | Genmab | 1.22% |
| EXEL | Exelixis | 1.18% |
| IONS | Ionis Pharmaceuticals | 1.14% |
Performance for IBB Top Holdings
| Ticker | Holding | Weight | Mkt Price5/21 | 1D Rtn | 1M Rtn | YTD Rtn | 1Y Rtn | 3Y Rtn | 5Y Rtn | 10Y Rtn |
|---|---|---|---|---|---|---|---|---|---|---|
| IBB | iShares Biotechnology ETF | 100.00% | 169.06 | 0.7% | -2.8% | 0.2% | 39.2% | 29.9% | 13.1% | 95.3% |
| GILD | Gilead Sciences | 7.44% | 130.50 | -0.1% | -2.1% | 6.9% | 24.4% | 83.8% | 128.7% | 122.9% |
| VRTX | Vertex Pharmaceuticals | 7.35% | 433.54 | 0.7% | -0.7% | -4.4% | -0.4% | 27.5% | 103.1% | 413.6% |
| AMGN | Amgen | 7.25% | 337.42 | 1.8% | -1.4% | 4.6% | 28.1% | 65.2% | 57.3% | 206.8% |
| REGN | Regeneron Pharmaceuticals | 6.21% | 642.59 | -1.1% | -13.9% | -16.5% | 6.9% | -13.8% | 27.9% | 65.0% |
| ALNY | Alnylam Pharmaceuticals | 3.69% | 300.51 | 0.7% | -2.6% | -24.4% | 2.7% | 55.7% | 114.6% | 436.0% |
| ARGX | argenx | 3.46% | 816.22 | 1.5% | 1.3% | -2.9% | 39.5% | 94.5% | 204.3% | |
| BIIB | Biogen | 2.58% | 189.47 | 0.9% | 1.9% | 7.7% | 49.4% | -38.3% | -33.1% | -22.3% |
| NTRA | Natera | 2.53% | 203.69 | -0.6% | -0.8% | -11.1% | 34.8% | 283.7% | 136.7% | 1,580.6% |
| RVMD | Revolution Medicines | 2.43% | 153.73 | 2.3% | 3.2% | 93.0% | 296.8% | 476.0% | 389.7% | |
| UTHR | United Therapeutics | 2.24% | 565.87 | 0.3% | -1.3% | 16.1% | 82.7% | 158.9% | 199.8% | 395.6% |
| INSM | Insmed | 2.16% | 109.53 | 1.5% | -22.3% | -37.1% | 65.9% | 439.3% | 323.7% | 865.9% |
| ONC | BeOne Medicines | 2.06% | 309.62 | 0.3% | -0.9% | 1.9% | 30.9% | 27.9% | -10.9% | 1,012.9% |
| ILMN | Illumina | 1.98% | 144.83 | 2.1% | 9.7% | 10.4% | 82.5% | -28.6% | -62.6% | 6.6% |
| INCY | Incyte | 1.80% | 97.41 | 0.3% | 1.2% | -1.4% | 50.4% | 51.3% | 17.7% | 20.7% |
| MRNA | Moderna | 1.63% | 47.26 | -1.8% | -12.9% | 60.3% | 83.2% | -62.7% | -70.7% | |
| ROIV | Roivant Sciences | 1.49% | 30.88 | -4.7% | 5.4% | 42.3% | 183.0% | 219.7% | 213.2% | |
| NBIX | Neurocrine Biosciences | 1.42% | 155.50 | 0.5% | 19.4% | 9.6% | 29.0% | 66.3% | 62.0% | 223.5% |
| GMAB | Genmab | 1.22% | 27.05 | -0.6% | -0.0% | -12.2% | 31.8% | -36.2% | -31.1% | 49.1% |
| EXEL | Exelixis | 1.18% | 49.65 | -0.5% | 8.2% | 13.3% | 13.6% | 151.1% | 103.0% | 727.5% |
| IONS | Ionis Pharmaceuticals | 1.14% | 75.78 | 1.0% | 1.3% | -4.2% | 126.2% | 86.1% | 109.3% | 122.4% |
Guidance Updates for IBB Top Holdings
| Ticker | Company | Earnings Date | Guidance Metric | Midpoint Value | % Change | Guidance Change | |
|---|---|---|---|---|---|---|---|
| ALNY_2122026 | ALNY | Alnylam Pharmaceuticals | 2/12/2026 | 2026 Total net product revenues | 5.10 Bil | 70.0% | Higher NewNew Guidance Higher than Prior Actual of 3.00 Bil for 2025 |
| INCY_2102026 | INCY | Incyte | 2/10/2026 | 2026 Total net product revenue | 4.86 Bil | 13.6% | Higher NewNew Guidance Higher than Prior Actual of 4.28 Bil for 2025 |
| IONS_4292026 | IONS | Ionis Pharmaceuticals | 4/29/2026 | 2026 Total Revenue | 887.50 Mil | 9.2% | RaisedRaised Prior Guidance of 812.50 Mil for 2026 |
Price Returns Compared
| 2021 | 2022 | 2023 | 2024 | 2025 | 2026 | Total [1] | |
|---|---|---|---|---|---|---|---|
| Returns | |||||||
| IBB Return | 1% | -14% | 4% | -2% | 28% | -1% | 12% |
| Peers Return | 28% | -8% | 33% | 14% | 34% | 36% | 227% |
| S&P 500 Return | 27% | -19% | 24% | 23% | 16% | 9% | 98% |
Monthly Win Rates [3] | |||||||
| IBB Win Rate | 42% | 50% | 58% | 58% | 58% | 40% | |
| Peers Win Rate | 62% | 48% | 57% | 55% | 68% | 76% | |
| S&P 500 Win Rate | 75% | 42% | 67% | 75% | 67% | 60% | |
Max Drawdowns [4] | |||||||
| IBB Max Drawdown | -17% | -31% | -18% | -12% | -21% | -10% | |
| Peers Max Drawdown | -22% | -38% | -19% | -20% | -28% | -14% | |
| S&P 500 Max Drawdown | -5% | -25% | -10% | -8% | -19% | -9% | |
[1] Cumulative total returns since the beginning of 2021
[2] Peers: SMH, SOXX, XBI, ITA, XOP.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 5/21/2026 (YTD)
Sharpe Ratios Compared
One measure of reward vs. risk is a Sharpe ratio. A higher ratio indicates better risk-adjusted returns. Most funds have Sharpe ratios < 1.0.
Results as of 4302026.How Low Can It Go
| Event | IBB | S&P 500 |
|---|---|---|
| 2025 US Tariff Shock | ||
| % Loss | -19.2% | -18.8% |
| % Gain to Breakeven | 23.7% | 23.1% |
| Time to Breakeven | 129 days | 79 days |
| Summer-Fall 2023 Five Percent Yield Shock | ||
| % Loss | -12.8% | -9.5% |
| % Gain to Breakeven | 14.7% | 10.5% |
| Time to Breakeven | 47 days | 24 days |
| 2022 Inflation Shock & Fed Tightening | ||
| % Loss | -30.5% | -24.5% |
| % Gain to Breakeven | 43.8% | 32.4% |
| Time to Breakeven | 1205 days | 427 days |
| 2020 COVID-19 Crash | ||
| % Loss | -23.6% | -33.7% |
| % Gain to Breakeven | 30.8% | 50.9% |
| Time to Breakeven | 32 days | 140 days |
| Q4 2018 Fed Policy Error / Growth Scare | ||
| % Loss | -26.1% | -19.2% |
| % Gain to Breakeven | 35.3% | 23.8% |
| Time to Breakeven | 357 days | 105 days |
| 2016-2017 Trump Reflation Bond Selloff | ||
| % Loss | -16.3% | -3.7% |
| % Gain to Breakeven | 19.5% | 3.9% |
| Time to Breakeven | 116 days | 6 days |
In The Past
iShares Biotechnology ETF's stock fell -19.2% during the 2025 US Tariff Shock. Such a loss loss requires a 23.7% gain to breakeven.
Preserve Wealth
Limiting losses and compounding gains is essential to preserving wealth.
Asset Allocation
Actively managed asset allocation strategies protect wealth. Learn more.
| Event | IBB | S&P 500 |
|---|---|---|
| 2022 Inflation Shock & Fed Tightening | ||
| % Loss | -30.5% | -24.5% |
| % Gain to Breakeven | 43.8% | 32.4% |
| Time to Breakeven | 1205 days | 427 days |
| 2020 COVID-19 Crash | ||
| % Loss | -23.6% | -33.7% |
| % Gain to Breakeven | 30.8% | 50.9% |
| Time to Breakeven | 32 days | 140 days |
| Q4 2018 Fed Policy Error / Growth Scare | ||
| % Loss | -26.1% | -19.2% |
| % Gain to Breakeven | 35.3% | 23.8% |
| Time to Breakeven | 357 days | 105 days |
| 2015-2016 China Devaluation / Global Growth Scare | ||
| % Loss | -34.3% | -12.2% |
| % Gain to Breakeven | 52.3% | 13.9% |
| Time to Breakeven | 1411 days | 62 days |
| 2011 US Debt Ceiling Crisis & European Contagion | ||
| % Loss | -22.3% | -17.9% |
| % Gain to Breakeven | 28.7% | 21.8% |
| Time to Breakeven | 155 days | 123 days |
| 2008-2009 Global Financial Crisis | ||
| % Loss | -29.3% | -53.4% |
| % Gain to Breakeven | 41.5% | 114.4% |
| Time to Breakeven | 196 days | 1085 days |
In The Past
iShares Biotechnology ETF's stock fell -19.2% during the 2025 US Tariff Shock. Such a loss loss requires a 23.7% gain to breakeven.
Preserve Wealth
Limiting losses and compounding gains is essential to preserving wealth.
Asset Allocation
Actively managed asset allocation strategies protect wealth. Learn more.
Current Dip Buy Opportunities Across ETFs
ETFs currently down 5% or more from trailing 6M peaks.
| Ticker | Name | Dip % | Mkt Price | Price Date | Peak Price | Peak Date | # Days |
|---|---|---|---|---|---|---|---|
| NOBL | ProShares S&P 500 Dividend Aristocrats ETF | -5.9% | 107.32 | 5212026 | 114.03 | 3012026 | 81 |
| JEPI | JPMorgan Equity Premium Income ETF | -5.1% | 56.08 | 5212026 | 59.09 | 3012026 | 81 |
| ARKK | ARK Innovation ETF | -7.9% | 76.62 | 5212026 | 83.21 | 1132026 | 128 |
| URA | Global X Uranium ETF | -21.0% | 48.86 | 5212026 | 61.81 | 1282026 | 113 |
| LIT | Global X Lithium & Battery Tech ETF | -7.9% | 84.38 | 5212026 | 91.62 | 5112026 | 10 |
| CGBL | Capital Group Core Balanced ETF | -6.2% | 34.41 | 5212026 | 36.67 | 2252026 | 85 |
| XLF | State Street Financial Select Sector SPDR ETF | -7.8% | 51.73 | 5212026 | 56.11 | 1062026 | 135 |
| XLV | State Street Health Care Select Sector SPDR ETF | -7.1% | 148.15 | 5212026 | 159.54 | 3012026 | 81 |
| XLE | State Street Energy Select Sector SPDR ETF | -5.5% | 59.13 | 5212026 | 62.56 | 3292026 | 53 |
| XLP | State Street Consumer Staples Select Sector SPDR ETF | -5.4% | 84.66 | 5212026 | 89.51 | 3012026 | 81 |
| XLU | State Street Utilities Select Sector SPDR ETF | -5.1% | 45.00 | 5212026 | 47.40 | 3012026 | 81 |
| XLB | State Street Materials Select Sector SPDR ETF | -6.3% | 50.02 | 5212026 | 53.38 | 2112026 | 99 |
| ITA | iShares U.S. Aerospace & Defense ETF | -10.9% | 223.15 | 5212026 | 250.42 | 3022026 | 80 |
| XOP | State Street SPDR S&P Oil & Gas Exploration & Production ETF | -9.3% | 170.65 | 5212026 | 188.18 | 3292026 | 53 |
| TLT | iShares 20+ Year Treasury Bond ETF | -6.6% | 84.22 | 5212026 | 90.16 | 3012026 | 81 |
| VGLT | Vanguard Long-Term Treasury ETF | -5.7% | 53.91 | 5212026 | 57.20 | 3012026 | 81 |
| SPTL | State Street SPDR Portfolio Long Term Treasury ETF | -6.1% | 25.61 | 5212026 | 27.28 | 3012026 | 81 |
| TLH | iShares 10-20 Year Treasury Bond ETF | -5.7% | 98.34 | 5212026 | 104.25 | 3012026 | 81 |
| EDV | Vanguard World Funds Extended Duration ETF | -9.1% | 62.11 | 5212026 | 68.33 | 3012026 | 81 |
| GSG | iShares GSCI Commodity | -5.8% | 30.01 | 5212026 | 31.85 | 3182026 | 64 |
| GLD | SPDR Gold Trust | -15.9% | 416.99 | 5212026 | 495.90 | 1292026 | 112 |
| IAU | iShares Gold Trust | -15.9% | 85.43 | 5212026 | 101.57 | 1292026 | 112 |
| GLDM | SPDR Gold MiniShares Trust | -15.8% | 89.87 | 5212026 | 106.77 | 1292026 | 112 |
| SGOL | ETFS Physical Swiss Gold Shares | -13.1% | 44.66 | 5212026 | 51.41 | 1292026 | 112 |
| BAR | Direxion Daily Gold Bull 3X Shares | -16.6% | 44.34 | 5212026 | 53.16 | 1292026 | 112 |
| SLV | iShares Silver Trust | -34.2% | 69.45 | 5212026 | 105.60 | 1282026 | 113 |
| SIVR | ETFS Physical Silver Shares Trust ETF | -24.8% | 83.39 | 5212026 | 110.87 | 1282026 | 113 |
| PPLT | ETFS Physical Platinum Shares | -29.3% | 17.84 | 5212026 | 25.23 | 1252026 | 116 |
| CPER | United States Copper Index Fund ETV | -13.9% | 33.33 | 5212026 | 38.71 | 1292026 | 112 |
| PALL | ETFS Physical Palladium Shares | -32.2% | 25.22 | 5212026 | 37.18 | 1282026 | 113 |
| USO | United States Oil Fund LP | -6.8% | 142.54 | 5212026 | 152.96 | 5192026 | 2 |
| UNG | United States Natural Gas Fund LP | -33.0% | 11.33 | 5212026 | 16.90 | 2012026 | 109 |
| BNO | United States Brent Oil Fund LP ETV | -7.1% | 55.85 | 5212026 | 60.13 | 5042026 | 17 |
| IBIT | iShares Bitcoin Trust ETF | -20.6% | 44.00 | 5212026 | 55.44 | 1142026 | 127 |
| FBTC | Fidelity Wise Origin Bitcoin Fund | -20.6% | 67.56 | 5212026 | 85.12 | 1142026 | 127 |
| GBTC | Grayscale Bitcoin Trust ETF | -19.0% | 61.84 | 5212026 | 76.31 | 1142026 | 127 |
| ETHA | iShares Ethereum Trust ETF | -36.9% | 16.15 | 5212026 | 25.59 | 1142026 | 127 |
About IBB
| Holdings Count: 250Expense Ratio: 0.44%Inception Date: 2001-02-05 | iShares Biotechnology ETFThe iShares Biotechnology ETF seeks to track the investment results of an index composed of U.S.-listed equities in the biotechnology sector.Asset Class: Equity | ETF Website |
Research & Analysis
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