Tearsheet

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0

Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -39%

Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 120%

Valuation becoming less expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is -55%

Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, and Precision Medicine. Themes include Gene Editing & Therapy, Targeted Therapies, Show more.

Weak multi-year price returns
2Y Excs Rtn is -31%, 3Y Excs Rtn is -86%

Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 11.05

Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -384 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -275%

Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 67%

Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -247%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -258%

Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -6.8%

Significant short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 22%

Key risks
BEAM key risks include [1] heightened regulatory scrutiny and trial delays due to its novel base editing technology, Show more.

0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -39%
1 Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 120%
2 Valuation becoming less expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is -55%
3 Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, and Precision Medicine. Themes include Gene Editing & Therapy, Targeted Therapies, Show more.
4 Weak multi-year price returns
2Y Excs Rtn is -31%, 3Y Excs Rtn is -86%
5 Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 11.05
6 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -384 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -275%
7 Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 67%
8 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -247%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -258%
9 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -6.8%
10 Significant short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 22%
11 Key risks
BEAM key risks include [1] heightened regulatory scrutiny and trial delays due to its novel base editing technology, Show more.

Valuation, Metrics & Events

Price Chart

Why The Stock Moved

Qualitative Assessment

AI Analysis | Feedback

Beam Therapeutics (BEAM) stock has remained largely at the same level since 12/31/2025 because of the following key factors:

1. Robust Clinical Pipeline Progress with Future Milestones.

Beam Therapeutics made significant strides in its clinical pipeline with promising updates for BEAM-302 in Alpha-1 Antitrypsin Deficiency (AATD), including the selection of a 60 mg optimal dose and alignment with the FDA on a potential accelerated approval pathway, with pivotal cohort initiation expected in the second half of 2026. Additionally, risto-cel for Sickle Cell Disease (SCD) saw positive Phase 1/2 data published in The New England Journal of Medicine on April 1, 2026, showing deep resolution of SCD markers and reduced hospital time. A U.S. Biologics License Application (BLA) submission is anticipated as early as year-end 2026. The announcement of a new program, BEAM-304 for Phenylketonuria (PKU), with an Investigational New Drug (IND) filing expected in 2026, further enhanced the long-term pipeline outlook. These advancements generated positive sentiment but, as many are still in development phases, maintained a balanced stock trajectory.

2. Strong Financial Foundation and Extended Cash Runway.

The company reported a strong financial position, ending 2025 with approximately $1.25 billion in cash, cash equivalents, and marketable securities. This was further bolstered by a $500 million non-dilutive senior credit facility from Sixth Street, which extended Beam's projected operating runway into mid-2029. This substantial liquidity provides stability, reduces immediate concerns about dilution, and supports ongoing research and development without heavily impacting the stock price.

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Stock Movement Drivers

Fundamental Drivers

The -2.2% change in BEAM stock from 12/31/2025 to 4/24/2026 was primarily driven by a -60.9% change in the company's P/S Multiple.
(LTM values as of)123120254242026Change
Stock Price ($)27.7227.11-2.2%
Change Contribution By: 
Total Revenues ($ Mil)56140150.9%
P/S Multiple51.020.0-60.9%
Shares Outstanding (Mil)103103-0.3%
Cumulative Contribution-2.2%

LTM = Last Twelve Months as of date shown

Market Drivers

12/31/2025 to 4/24/2026
ReturnCorrelation
BEAM-2.2% 
Market (SPY)4.2%34.6%
Sector (XLV)-6.9%33.8%

Fundamental Drivers

The 11.7% change in BEAM stock from 9/30/2025 to 4/24/2026 was primarily driven by a 131.9% change in the company's Total Revenues ($ Mil).
(LTM values as of)93020254242026Change
Stock Price ($)24.2727.1111.7%
Change Contribution By: 
Total Revenues ($ Mil)60140131.9%
P/S Multiple41.120.0-51.4%
Shares Outstanding (Mil)102103-0.9%
Cumulative Contribution11.7%

LTM = Last Twelve Months as of date shown

Market Drivers

9/30/2025 to 4/24/2026
ReturnCorrelation
BEAM11.7% 
Market (SPY)7.0%36.8%
Sector (XLV)4.0%32.3%

Fundamental Drivers

The 38.8% change in BEAM stock from 3/31/2025 to 4/24/2026 was primarily driven by a 120.0% change in the company's Total Revenues ($ Mil).
(LTM values as of)33120254242026Change
Stock Price ($)19.5327.1138.8%
Change Contribution By: 
Total Revenues ($ Mil)64140120.0%
P/S Multiple25.520.0-21.6%
Shares Outstanding (Mil)83103-19.5%
Cumulative Contribution38.8%

LTM = Last Twelve Months as of date shown

Market Drivers

3/31/2025 to 4/24/2026
ReturnCorrelation
BEAM38.8% 
Market (SPY)28.1%43.0%
Sector (XLV)0.1%40.1%

Fundamental Drivers

The -11.5% change in BEAM stock from 3/31/2023 to 4/24/2026 was primarily driven by a -43.9% change in the company's P/S Multiple.
(LTM values as of)33120234242026Change
Stock Price ($)30.6227.11-11.5%
Change Contribution By: 
Total Revenues ($ Mil)61140129.4%
P/S Multiple35.620.0-43.9%
Shares Outstanding (Mil)71103-31.2%
Cumulative Contribution-11.5%

LTM = Last Twelve Months as of date shown

Market Drivers

3/31/2023 to 4/24/2026
ReturnCorrelation
BEAM-11.5% 
Market (SPY)79.8%38.1%
Sector (XLV)16.6%32.6%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
BEAM Return-2%-51%-30%-9%12%9%-63%
Peers Return-0%-43%9%-51%21%29%-53%
S&P 500 Return27%-19%24%23%16%4%89%

Monthly Win Rates [3]
BEAM Win Rate50%33%50%33%75%50% 
Peers Win Rate27%37%48%37%52%65% 
S&P 500 Win Rate75%42%67%75%67%50% 

Max Drawdowns [4]
BEAM Max Drawdown-21%-63%-55%-22%-41%-21% 
Peers Max Drawdown-31%-52%-28%-53%-32%-10% 
S&P 500 Max Drawdown-1%-25%-1%-2%-15%-7% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: CRSP, NTLA, EDIT, VRTX, PRME.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 4/24/2026 (YTD)

How Low Can It Go

Unique KeyEventBEAMS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-86.8%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven655.2%34.1%
2022 Inflation ShockTime to BreakevenTime to BreakevenNot Fully Recovered days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-54.4%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven119.4%51.3%
2020 Covid PandemicTime to BreakevenTime to Breakeven112 days148 days

Compare to CRSP, NTLA, EDIT, VRTX, PRME

In The Past

Beam Therapeutics's stock fell -86.8% during the 2022 Inflation Shock from a high on 7/1/2021. A -86.8% loss requires a 655.2% gain to breakeven.

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About Beam Therapeutics (BEAM)

Beam Therapeutics Inc., a biotechnology company, develops precision genetic medicines for patients suffering from serious diseases in the United States. The company is developing BEAM-101 for the treatment of sickle cell disease and beta thalassemia; BEAM-102 for the treatment of sickle cell disease; and BEAM-201, an allogeneic chimeric antigen receptor T cell for the treatment of relapsed/refractory T-cell acute lymphoblastic leukemia; and BEAM-301, a liver-targeted development candidate for the treatment of patients with Glycogen Storage Disease Type Ia. It also develops therapies for alpha-1 antitrypsin deficiency; ocular diseases; and other liver, muscle, and central nervous system disorders. The company has an alliance with Boston Children's Hospital; a research and clinical trial collaboration agreement with Magenta Therapeutics, Inc.; license agreement with Sana Biotechnology, Inc.; and a research collaboration with the Institute of Molecular and Clinical Ophthalmology Basel. It also has a research collaboration agreement with Pfizer Inc. and Apellis Pharmaceuticals, Inc.; and collaboration and license agreement with Verve Therapeutics, Inc. The company was incorporated in 2017 and is based in Cambridge, Massachusetts.

AI Analysis | Feedback

Here are 1-2 brief analogies to describe Beam Therapeutics:

  • Beam Therapeutics is like Moderna for genetic disease cures, using a revolutionary DNA editing technology.
  • Imagine CRISPR Therapeutics, but with a more precise 'base editing' technology to fix genetic diseases.

AI Analysis | Feedback

  • BEAM-101: A genetic medicine candidate for the treatment of sickle cell disease and beta thalassemia.
  • BEAM-102: A genetic medicine candidate specifically targeting the treatment of sickle cell disease.
  • BEAM-201: An allogeneic chimeric antigen receptor T cell (CAR-T) therapy for relapsed/refractory T-cell acute lymphoblastic leukemia.
  • BEAM-301: A liver-targeted development candidate for the treatment of patients with Glycogen Storage Disease Type Ia.

AI Analysis | Feedback

Beam Therapeutics primarily generates revenue through collaborations, partnerships, and licensing agreements with other biotechnology and pharmaceutical companies. As a biotechnology company in the development stage, it does not currently sell commercial products directly to individual patients or healthcare providers.

Its major customers and partners, based on the agreements described, include:

  • Sana Biotechnology, Inc.
  • Pfizer Inc. (PFE)
  • Apellis Pharmaceuticals, Inc. (APLS)
  • Verve Therapeutics, Inc. (VERV)

AI Analysis | Feedback

Sana Biotechnology, Inc. (SANA)

Verve Therapeutics, Inc. (VERV)

AI Analysis | Feedback

John Evans, Chief Executive Officer and Board Member

John Evans joined Beam Therapeutics in 2017 as Chief Executive Officer and a director. He has extensive experience in company-building, corporate development, and drug development within the biotechnology industry. Prior to Beam, Mr. Evans was an early employee and a member of the leadership team at Agios Pharmaceuticals, most recently serving as Senior Vice President for Corporate Development and Portfolio Leadership. At Agios, he provided strategic and operational leadership for a portfolio of IDH inhibitors, including IDHIFA and TIBSOVO, and helped lead Agios' alliance with Celgene. He also co-led Agios' expansion into rare genetic diseases. Before Agios, Mr. Evans worked at Infinity Pharmaceuticals, McKinsey & Company (Pharmaceuticals practice), and MedImmune. Mr. Evans served as interim CEO for Prime Medicine Inc. and continues to serve on its board. He also held a Venture Partner role at ARCH Venture Partners LLC from April 2017 to March 2021, a firm that invests in early-stage biotechnology companies. Additionally, he is on the board of Verve Therapeutics, Inc. and Orbital Therapeutics, Inc.

Sravan Emany, Chief Financial Officer

Sravan Emany was appointed Chief Financial Officer of Beam Therapeutics, effective December 19, 2024. He previously served as CFO and Chief Operating Officer at Ironwood Pharmaceuticals, Inc. Before Ironwood, Mr. Emany held roles as Corporate Vice President, Commercial Excellence and Chief Strategy Officer, and Vice President of Strategy, Treasury and Investor Relations at Integra LifeSciences Holdings Corporation. Earlier in his career, he spent nearly a decade in various mergers and acquisitions investment banking roles at Bank of America and BofA Securities, where he became a Managing Director and led numerous healthcare M&A transactions.

Giuseppe Ciaramella, Ph.D., President

Dr. Giuseppe Ciaramella is the President of Beam Therapeutics. He was previously the President and Chief Scientific Officer from 2020 to 2023, and Chief Scientific Officer from 2018 to 2020. Dr. Ciaramella brings over 20 years of drug discovery experience from leading pharmaceutical companies. He served as the Chief Scientific Officer of the Infectious Diseases division at Moderna Therapeutics, where he was instrumental in developing some of the first mRNA vaccines for human dosing. His career also includes leadership positions at AstraZeneca, Boehringer Ingelheim, Pfizer, and Merck, with a focus on antivirals, immunology, and biotherapeutics. At Pfizer, he held several Discovery leadership roles, including head of Biotherapeutics, Antivirals, and Lead Discovery, and contributed to the development of the anti-HIV drug Maraviroc (Selzentry™). He is also a co-founder and CEO of Orbital Therapeutics since 2022.

Amy Simon, M.D., Chief Medical Officer

Dr. Amy Simon serves as the Chief Medical Officer at Beam Therapeutics.

Susan O'Connor, Chief Human Resources Officer

Susan O'Connor is the Chief Human Resources Officer at Beam Therapeutics.

AI Analysis | Feedback

The key risks to Beam Therapeutics' business are primarily associated with the inherent challenges of developing novel genetic medicines, navigating a competitive landscape, and maintaining substantial funding for its pipeline.

  1. Clinical Trial and Regulatory Success: As a biotechnology company focused on precision genetic medicines, Beam Therapeutics' valuation and future success are heavily reliant on the successful progression of its drug candidates through clinical trials and ultimately obtaining regulatory approval. Any delays in patient enrollment, unexpected adverse events, or failures in clinical programs, such as BEAM-101 for sickle cell disease or BEAM-302 for alpha-1 antitrypsin deficiency, would significantly impact the company's prospects and stock price. The use of novel base editing technology also introduces heightened regulatory scrutiny and uncertainty regarding long-term safety and efficacy. For instance, a patient death in the BEAM-101 trial, though attributed to the busulfan conditioning regimen rather than the drug itself, underscores the severe risks associated with the overall treatment process for some genetic therapies.

  2. Intense Competition: Beam Therapeutics operates in a highly competitive gene editing and therapy market. The company faces significant competition from established players, including those with approved products like CRISPR Therapeutics' Casgevy for sickle cell disease. Competitors with potentially more advanced therapies, greater financial resources, or superior expertise in research and development could outpace Beam Therapeutics in bringing products to market, thereby reducing its commercial opportunities and market share.

  3. Financial Constraints and Funding Needs: Beam Therapeutics is a development-stage company with a history of substantial operating losses and significant research and development expenses, which are expected to continue for the foreseeable future. While the company has secured funding that extends its cash runway, it will require substantial additional capital to support ongoing development activities and advance its extensive pipeline to commercialization. Failure to secure this funding could lead to delays or reductions in crucial research and development programs and potential dilution for existing shareholders through future equity raises.

AI Analysis | Feedback

The advancement and potential clinical superiority of next-generation gene editing technologies, such as prime editing, being developed by companies like Prime Medicine, Inc. Prime editing is designed to offer a wider range of precise genetic modifications with potentially improved safety and efficacy profiles compared to Beam Therapeutics' base editing platform, particularly for indications like sickle cell disease where Beam has lead candidates. If prime editing demonstrates clear advantages in clinical development, it could diminish the competitive position of base editing as a core therapeutic modality.

AI Analysis | Feedback

Beam Therapeutics (symbol: BEAM) is developing precision genetic medicines for various serious diseases. The addressable markets for their main product candidates are substantial across global and U.S. regions.

BEAM-101 (Sickle Cell Disease and Beta Thalassemia) and BEAM-102 (Sickle Cell Disease)

  • Sickle Cell Disease (SCD): The global sickle cell disease treatment market was valued at approximately USD 3.75 billion in 2025 and is projected to reach around USD 14.06 billion by 2034, expanding at a Compound Annual Growth Rate (CAGR) of 15.81% over the forecast period from 2025 to 2034. Another estimate indicates the global market size was USD 4.73 billion in 2026 and is projected to reach USD 20.47 billion by 2034, exhibiting a CAGR of 20.10%. North America held a significant market share, with the United States dominating the SCD treatment market, accounting for 63.35% in 2025. The North America sickle cell disease market, estimated at USD 1,400.2 million in 2025, is expected to reach USD 4,005.3 million by 2032.
  • Beta Thalassemia: The global beta thalassemia market is projected to expand at an 8.5% CAGR, growing from USD 1.9 billion in 2024 to USD 3.1 billion by 2030. Other reports indicate the global market size was valued at USD 9.70 billion in 2024 and is expected to reach USD 17.96 billion by 2032. In the United States, the beta thalassemia market was valued at approximately USD 358 million in 2023 and is projected to expand significantly by 2034. The U.S. beta-thalassemia market captured the largest revenue share of 81% within North America in 2024. The 7 major Beta Thalassemia markets (US, EU4, UK, and Japan) reached a value of USD 368.7 Million in 2024 and are expected to reach USD 901.7 Million by 2035.

BEAM-201 (Relapsed/Refractory T-cell Acute Lymphoblastic Leukemia)

  • Relapsed/Refractory T-cell Acute Lymphoblastic Leukemia (T-ALL): The global T-cell Acute Lymphoblastic Leukemia Treatment Market was valued at USD 3,254.67 million in 2025 and is expected to increase to USD 4,672.03 million by 2032, at a Compound Annual Growth Rate (CAGR) of 5.3%. North America is estimated to exhibit the highest CAGR for the T-cell Acute Lymphoblastic Leukemia Treatment Market over the forecast period of 2025-2030.

BEAM-301 (Glycogen Storage Disease Type Ia)

  • Glycogen Storage Disease Type Ia (GSDIa): GSDIa is a rare inherited disorder. In the U.S., the prevalence of GSD type Ia alone is estimated at 1 in 100,000 individuals. The mean annual healthcare cost for a GSDIa patient in the U.S. is approximately $33,910 per patient in 2024. Currently, there are no FDA-approved therapies for GSD-1a. The top 7 (US, EU4, UK, and Japan) glycogen storage disease markets (encompassing all GSD types) are expected to exhibit a CAGR of 5.58% during 2025-2035.

AI Analysis | Feedback

Beam Therapeutics (BEAM) is anticipated to drive future revenue growth over the next 2-3 years through several key initiatives:

  • Commercialization of Risto-cel (BEAM-101) for Sickle Cell Disease: The company anticipates submitting a Biologics License Application (BLA) for risto-cel, an investigational autologous cell therapy for sickle cell disease, as early as year-end 2026. This pivotal step towards regulatory approval and potential launch, supported by a strategic financing agreement, positions risto-cel as a significant near-term revenue driver.
  • Advancement of BEAM-302 for Alpha-1 Antitrypsin Deficiency (AATD): Initial clinical data from multiple cohorts for BEAM-302, a potential one-time treatment for AATD, is expected in 2025. Plans for pivotal development are anticipated in the first quarter of 2026, suggesting a pathway to market and future revenue generation.
  • Expansion of the Sickle Cell Disease Patient Population via the ESCAPE Program: Beam's ESCAPE program, which includes development candidates like BEAM-103 and BEAM-104, aims to provide non-genotoxic conditioning for ex vivo gene therapy. This approach is designed to eliminate chemotherapy and expand the eligible patient population for sickle cell disease treatments, significantly increasing the long-term market potential and associated revenues for Beam's SCD therapies.
  • Progression of New Liver-Targeted Genetic Disease Programs (BEAM-301 & BEAM-304): The company expects initial data for BEAM-301 in Glycogen Storage Disease Type Ia (GSDIa) in 2026, following its first patient dosing in early 2025. Additionally, an Investigational New Drug (IND) filing for BEAM-304, a new liver-targeted program for phenylketonuria (PKU), is expected in 2026, with a Phase 1/2 trial to follow. These advancements open new therapeutic areas and represent future revenue streams as they move through clinical development.

AI Analysis | Feedback

Share Issuance

  • In September 2020, Beam Therapeutics priced a public offering of 5,000,000 shares of common stock at $23.50 per share, generating gross proceeds of approximately $117.5 million.
  • In October 2023, Beam received a $50 million equity investment from Eli Lilly and Company as part of a broader collaboration and license agreement.

Inbound Investments

  • In January 2022, Beam Therapeutics entered into a four-year research collaboration with Pfizer Inc., receiving an upfront payment of $300 million and potentially up to $1.05 billion in future milestone payments and royalties.
  • In October 2023, Eli Lilly and Company acquired Beam's opt-in rights to certain Verve Therapeutics' base editing programs, providing Beam with a $200 million upfront payment and eligibility for up to $350 million in potential future development-stage payments.
  • In February 2026, Beam Therapeutics secured a strategic financing agreement with Sixth Street for a senior secured credit facility of up to $500 million, including an initial $100 million funded at close. An additional $300 million is available upon achieving certain clinical, regulatory, and commercial milestones for risto-cel.

Capital Expenditures

  • Capital expenditures were $47 million in 2021, $49 million in 2022, and $34 million in 2023.
  • In the fourth quarter of 2025, capital expenditures were $3.7 million.
  • Beam initiated GMP operations at its North Carolina manufacturing facility, indicating a focus on expanding internal manufacturing capabilities. The company expects its capital resources to cover anticipated capital expenditure requirements into mid-2029.

Better Bets vs. Beam Therapeutics (BEAM)

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WAT_3202026_Monopoly_xInd_xCD_Getting_Cheaper03202026WATWatersMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
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Recent Active Movers

Peer Comparisons

Peers to compare with:

Financials

BEAMCRSPNTLAEDITVRTXPRMEMedian
NameBeam The.CRISPR T.Intellia.Editas M.Vertex P.Prime Me. 
Mkt Price27.1148.7813.632.91430.293.7020.37
Mkt Cap2.84.71.60.3109.10.72.2
Rev LTM1400684112,001554
Op Inc LTM-384-665-441-994,554-208-296
FCF LTM-360-371-396-1663,194-167-264
FCF 3Y Avg-300-263-386-1741,832-157-218
CFO LTM-345-345-395-1653,631-163-255
CFO 3Y Avg-281-249-379-1692,225-150-209

Growth & Margins

BEAMCRSPNTLAEDITVRTXPRMEMedian
NameBeam The.CRISPR T.Intellia.Editas M.Vertex P.Prime Me. 
Rev Chg LTM120.0%-100.0%16.9%25.4%8.9%55.3%21.2%
Rev Chg 3Y Avg185.6%28,190.6%15.4%87.7%10.4%-87.7%
Rev Chg Q279.5%-100.0%78.8%-19.2%9.5%-61.6%-4.8%
QoQ Delta Rev Chg LTM150.9%-100.0%17.6%-12.6%2.4%-22.5%-5.1%
Op Inc Chg LTM7.7%-42.4%17.5%58.4%2,051.3%-2.9%12.6%
Op Inc Chg 3Y Avg-26.6%-28.4%0.4%14.1%644.7%-24.3%-11.9%
Op Mgn LTM-274.6%--651.7%-245.2%37.9%-4,498.1%-274.6%
Op Mgn 3Y Avg-325.2%--998.4%-400.4%24.7%--362.8%
QoQ Delta Op Mgn LTM562.6%-180.5%12.9%38.7%-1,085.6%38.7%
CFO/Rev LTM-247.0%--583.3%-407.8%30.3%-3,509.6%-407.8%
CFO/Rev 3Y Avg-277.7%--757.5%-409.3%20.5%--343.5%
FCF/Rev LTM-257.7%--585.0%-409.3%26.6%-3,607.4%-409.3%
FCF/Rev 3Y Avg-289.0%--774.2%-420.9%17.0%--354.9%

Valuation

BEAMCRSPNTLAEDITVRTXPRMEMedian
NameBeam The.CRISPR T.Intellia.Editas M.Vertex P.Prime Me. 
Mkt Cap2.84.71.60.3109.10.72.2
P/S20.0-23.47.09.1141.620.0
P/Op Inc-7.3-7.0-3.6-2.924.0-3.1-3.4
P/EBIT-7.3-7.0-3.6-1.823.4-3.1-3.4
P/E-34.9-8.0-3.8-1.827.6-3.3-3.5
P/CFO-8.1-13.5-4.0-1.730.0-4.0-4.0
Total Yield-2.9%-12.5%-26.1%-56.5%3.6%-30.7%-19.3%
Dividend Yield0.0%0.0%0.0%0.0%0.0%0.0%0.0%
FCF Yield 3Y Avg-12.8%-5.7%-27.5%-102.8%1.7%-27.5%-20.1%
D/E0.10.00.10.10.00.20.1
Net D/E-0.4-0.4-0.2-0.5-0.0-0.1-0.3

Returns

BEAMCRSPNTLAEDITVRTXPRMEMedian
NameBeam The.CRISPR T.Intellia.Editas M.Vertex P.Prime Me. 
1M Rtn17.3%3.6%2.8%25.4%-5.4%1.9%3.2%
3M Rtn-14.1%-12.1%-6.8%34.7%-8.1%-16.5%-10.1%
6M Rtn-3.0%-27.8%-46.8%-21.8%2.1%-30.6%-24.8%
12M Rtn34.4%24.7%66.6%80.7%-12.6%111.4%50.5%
3Y Rtn-10.9%-1.3%-62.4%-62.2%29.6%-71.3%-36.6%
1M Excs Rtn8.6%-5.1%-5.9%16.7%-14.1%-6.8%-5.5%
3M Excs Rtn-17.7%-15.7%-10.4%31.1%-11.7%-20.1%-13.7%
6M Excs Rtn-9.0%-33.6%-51.5%-25.4%-6.0%-34.5%-29.5%
12M Excs Rtn3.2%-6.7%35.2%53.3%-45.9%74.6%19.2%
3Y Excs Rtn-86.2%-81.2%-136.3%-136.5%-41.5%-145.7%-111.3%

Comparison Analyses

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Financials

Segment Financials

Revenue by Segment
$ Mil20252024202320222021
Single Segment6437861520
Total6437861520


Net Income by Segment
$ Mil20252024202320222021
Single Segment-377    
Total-377    


Price Behavior

Price Behavior
Market Price$27.11 
Market Cap ($ Bil)2.8 
First Trading Date02/06/2020 
Distance from 52W High-23.4% 
   50 Days200 Days
DMA Price$26.99$24.80
DMA Trendupdown
Distance from DMA0.4%9.3%
 3M1YR
Volatility68.7%74.0%
Downside Capture2.191.67
Upside Capture233.27246.09
Correlation (SPY)45.2%36.9%
BEAM Betas & Captures as of 3/31/2026

 1M2M3M6M1Y3Y
Beta0.891.421.291.861.641.77
Up Beta1.952.551.941.871.281.38
Down Beta-2.20-1.95-1.100.111.291.60
Up Capture154%241%235%368%407%968%
Bmk +ve Days7162765139424
Stock +ve Days9182657119352
Down Capture223%223%199%193%157%113%
Bmk -ve Days12233358110323
Stock -ve Days12233668131392

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with BEAM
BEAM41.6%73.9%0.78-
Sector ETF (XLV)7.7%15.8%0.2833.7%
Equity (SPY)34.0%12.6%2.0536.7%
Gold (GLD)42.9%27.2%1.299.4%
Commodities (DBC)46.4%18.0%1.97-2.8%
Real Estate (VNQ)14.2%13.3%0.7427.0%
Bitcoin (BTCUSD)-16.6%42.1%-0.3225.0%

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Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with BEAM
BEAM-16.9%75.5%0.08-
Sector ETF (XLV)5.1%14.6%0.1734.6%
Equity (SPY)12.7%17.1%0.5845.6%
Gold (GLD)21.2%17.8%0.977.0%
Commodities (DBC)14.5%19.1%0.626.5%
Real Estate (VNQ)3.7%18.8%0.1038.7%
Bitcoin (BTCUSD)7.0%56.3%0.3429.0%

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Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with BEAM
BEAM4.1%80.5%0.44-
Sector ETF (XLV)9.3%16.5%0.4631.3%
Equity (SPY)14.9%17.9%0.7139.5%
Gold (GLD)13.9%15.9%0.738.8%
Commodities (DBC)10.1%17.8%0.4710.8%
Real Estate (VNQ)5.4%20.7%0.2332.0%
Bitcoin (BTCUSD)68.3%66.9%1.0727.0%

Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date4152026
Short Interest: Shares Quantity22.2 Mil
Short Interest: % Change Since 3312026-4.9%
Average Daily Volume2.0 Mil
Days-to-Cover Short Interest11.0 days
Basic Shares Quantity102.9 Mil
Short % of Basic Shares21.6%

Earnings Returns History

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 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
2/24/202614.0%1.3%-15.5%
11/4/2025-6.2%-10.7%19.2%
8/5/2025-2.2%-10.2%-1.9%
5/6/2025-19.3%-8.0%-13.5%
2/25/2025-3.1%-18.5%-24.6%
11/5/2024-1.8%24.6%6.8%
8/6/2024-0.4%-6.4%-6.0%
5/7/2024-1.1%5.4%7.5%
...
SUMMARY STATS   
# Positive888
# Negative151515
Median Positive4.3%7.7%8.4%
Median Negative-3.7%-5.6%-12.1%
Max Positive25.9%24.6%97.2%
Max Negative-19.3%-18.5%-24.6%

SEC Filings

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Report DateFiling DateFiling
12/31/202502/24/202610-K
09/30/202511/04/202510-Q
06/30/202508/05/202510-Q
03/31/202505/06/202510-Q
12/31/202402/25/202510-K
09/30/202411/05/202410-Q
06/30/202408/06/202410-Q
03/31/202405/07/202410-Q
12/31/202302/27/202410-K
09/30/202311/08/202310-Q
06/30/202308/08/202310-Q
03/31/202305/10/202310-Q
12/31/202202/28/202310-K
09/30/202211/07/202210-Q
06/30/202208/09/202210-Q
03/31/202205/09/202210-Q