• Pfizer for psychedelic medicines.
• Moderna for psychedelic mental health treatments.

• Psilocybin-Assisted Psychotherapy (Palliative Care): A therapeutic program combining psilocybin with psychotherapy designed to alleviate mental distress in patients with life-limiting illnesses.
• Novel Psychedelic Drug Pipeline: Research and development of proprietary psychedelic compounds and formulations for various medical indications.
• Pharmaceutical-Grade Psychedelic Manufacturing: The development of infrastructure and processes for the cultivation, extraction, and production of high-quality, standardized psychedelic compounds for medical use.

Psyence Biomedical (symbol: PBM) is a clinical-stage biotechnology company focused on the development of psilocybin-based treatments, primarily for mental health challenges in oncology and palliative care. As a company in the research and development phase, with its lead drug candidate, PSYG-002, currently in Phase 2a clinical trials, Psyence Biomedical does not yet have major customers in the traditional sense that are purchasing its products or services.

The company's business model is centered on developing and gaining regulatory approval for its therapeutic candidates, with the aim of future commercialization within the healthcare system. Upon potential approval, their products would be integrated into healthcare systems and administered by medical professionals. Therefore, their ultimate beneficiaries would be patients, facilitated through healthcare providers and institutions, rather than direct sales to individuals or other companies at this stage of development.

Optimi Health Corp. (OPTI)

Jody Aufrichtig Chief Executive Officer

Jody Aufrichtig is an award-winning entrepreneur, business builder, impact investor, and philanthropist. A Chartered Accountant by training, he has built significant and rapid shareholder value in 19 businesses across a broad range of sectors including cannabis, private equity, travel and tourism, and sport and leisure. He previously headed Canopy Growth's African operations. He also has experience in managing companies within the private equity sector.

Warwick Corden-Lloyd Chief Financial Officer

Warwick Corden-Lloyd is a Chartered Accountant and Certified Project Manager with over 17 years of work experience in the United Kingdom, the USA, and South Africa. His experience ranges from advising the boards of publicly traded companies to strategy design for start-ups. He served as VP Operations and Finance for Canopy Growth Africa and prior to that was the Head of Financial Accounting for Capitec Bank.

Dr. Neil Maresky Global Head of Clinical Development

Dr. Neil Maresky transitioned to Global Head of Clinical Development in October 2025, having previously served as CEO. Before joining Psyence Biomedical, he was the Vice President Scientific Affairs at AstraZeneca, Canada Inc. He has over 17 years of experience in research-based pharmaceuticals, holding positions with Wyeth, Bayer, and Novartis, including serving as Director of Drug Safety and Pharmaco-epidemiology. Dr. Maresky also worked as a family physician with experience in cardiology and emergency room care and has published in journals such as Human Vaccines and The Canadian Journal of Clinical Pharmacology.

Christopher Bull Independent Director

Christopher Bull is a qualified chemical engineer, attorney, patent attorney, and Certified Licensing Professional®. An alumnus of Said Business School, Oxford University (Private Equity and Venture Capital), he has a 30-year career as an investor, director, founder, and advisor to successful companies in Europe and North America. His expertise lies in novel technologies within pharmaceuticals, biotechnology, food sciences, chemical processing, and extraction technologies, and he is recognized for his skills in venture capital investment, patent, and intellectual property strategies for high-technology companies.

Dr. Seth Feuerstein Board Member

Dr. Seth Feuerstein is faculty at Yale School of Medicine in the Department of Psychiatry. He is a founding board member of the Center for Biomedical and Interventional Technology at Yale and Executive Director of the Center for Digital Health, Innovation and Excellence. Dr. Feuerstein teaches at the medical school and serves as the faculty advisor for Innovation in Healthcare at the Yale School of Medicine, working across various healthcare sectors including health insurance, healthcare startups, healthcare investing, and clinical care delivery innovation.

The clear emerging threat to Psyence Biomedical (PBM) is the advancement of alternative psychedelic compounds and therapeutic approaches by competitors that could offer perceived advantages over psilocybin-based treatments for anxiety and distress, particularly within palliative care settings. Specifically, companies like Cybin Inc. (NYSE: CYBN) are developing novel psychedelic compounds such as deuterated DMT analogs (e.g., CYB004) for conditions like Generalized Anxiety Disorder (GAD). While PBM focuses on psilocybin for existential distress in palliative care, anxiety is a core component of this distress. If a shorter-acting psychedelic therapy like CYB004 proves effective and gains regulatory approval for GAD or related conditions, its potentially quicker onset and shorter duration of action could be seen as advantageous for certain patient populations, including those in palliative care who might be frail or prefer a less prolonged experience. This could divert market share or establish a preferred treatment paradigm, challenging PBM's psilocybin-focused approach.

Psyence Biomedical (PBM) focuses on nature-derived psilocybin and ibogaine therapies for mental health needs, particularly within palliative care. Their lead product candidate, PEX010, is a naturally sourced psilocybin capsule currently in a Phase IIb clinical study for the treatment of adjustment disorder in cancer patients. The company also has a strategic collaboration for the production of ibogaine.

The addressable markets for their main products and services are significant:

• The global market for psilocybin-assisted therapy is projected to grow from an estimated $1.5 billion in 2024 to $3.3 billion by 2031.
• More broadly, the global psychedelic therapeutics market size was estimated at USD 2.94 billion in 2025 and is predicted to increase to approximately USD 11.03 billion by 2034.
• Another estimate for the global psilocybin assisted therapy market valued it at USD 3.1 billion in 2025, with projections to reach USD 11.8 billion by the end of 2035.
• In the U.S. specifically, a November 2024 study from Emory University suggested that psilocybin-assisted therapy could benefit over 5 million individuals.

Psyence Biomedical (PBM) is anticipating several key drivers to fuel its revenue growth over the next 2-3 years, primarily centered around the advancement of its psychedelic-based therapeutics and strategic market positioning:

1. Successful Clinical Development and Commercialization of PEX010 for Adjustment Disorder in Palliative Care: The company's lead product candidate, PEX010, a nature-derived psilocybin-based therapeutic, is currently in a Phase IIb clinical trial for Adjustment Disorder in palliative care. Successful completion of these trials, followed by regulatory approval, is expected to be a significant driver of future revenue as it would allow PBM to bring this treatment to market. Topline results from this trial are anticipated by the end of 2026.
2. Expansion into New Therapeutic Indications: Psyence Biomedical is strategically expanding its clinical pipeline beyond palliative care. The company is in the process of forming a steering committee to initiate a clinical trial for naturally sourced psilocybin in the treatment of Alcohol Use Disorder (AUD) and other Substance Use Disorders (SUD). This diversification into additional, large market indications represents a substantial opportunity for future revenue growth.
3. Leveraging a Vertically Integrated and Secure Supply Chain for GMP-grade Psychedelics: Through significant follow-on investments in PsyLabs, Psyence Biomedical has secured access to GMP-grade (Good Manufacturing Practice) psilocybin and ibogaine. This strategic vertical integration ensures a sustainable, ethical, and high-quality supply chain for its clinical research programs and eventual commercial products. The ability to control and provide GMP-aligned psychedelic active pharmaceutical ingredients (APIs), including Ibogaine Total Alkaloid extract production, is a competitive advantage in the rapidly evolving psychedelic medicine market.

Share Issuance

• Psyence Biomedical completed a private placement on December 27, 2024, issuing 1,000,000 common shares (or pre-funded warrants in lieu thereof) at a purchase price of $2.00 per share, generating approximately $2.0 million in gross proceeds.
• In 2024, the company issued 3,000 common shares to Donohoe Advisory Associates LLC and 25,000 common shares to Outside The Box Capital Inc. for accrued service and past service delivery, with an additional 172,028 common shares issued to Outside The Box Capital Inc. on August 12, 2024.
• A prospectus filed on July 25, 2024, detailed the potential offer and sale of up to 50,375,000 common shares to White Lion Capital, LLC through an equity line of credit.

Inbound Investments

• Psyence Biomedical completed a private placement on December 27, 2024, resulting in approximately $2.0 million in gross proceeds intended for working capital and general corporate purposes.

Outbound Investments

• On November 3, 2025, Psyence Biomedical announced a $3,500,000 follow-on investment in PsyLabs, a key producer of purified psychedelic active pharmaceutical ingredients (APIs).
• This $3,500,000 investment made on August 15, 2025, built upon a previous $500,000 investment in PsyLabs that occurred in April 2025.

Capital Expenditures

• Capital expenditures for Psyence Biomedical were -$9,880 for fiscal year 2025 and -$5,730 for fiscal year 2024.
• The company's operational focus, which entails capital expenditure, includes cultivating natural psilocybin mushrooms at its federally licensed facility in Southern Africa for the production of standardized encapsulated products.