Tearsheet

iSpecimen (ISPC)


Market Price (12/4/2025): $0.4419 | Market Cap: $1.1 Mil
Sector: Health Care | Industry: Life Sciences Tools & Services

iSpecimen (ISPC)


Market Price (12/4/2025): $0.4419
Market Cap: $1.1 Mil
Sector: Health Care
Industry: Life Sciences Tools & Services

Investment Highlights Why It Matters Which of these 2 stories sounds closer for this stock?

1. Generates cash flow

The stock generated 4% or more of the share price (called cash flow yield), and shows moderate 10-15% or more growth.

2. Riding a trend

Think Tesla during the pandemic of 2020 when EVs were riding a cultural high, or Nvidia in the current AI boom, or even Figma. These companies don’t have enough yield, or, enough growth, or both - however - they are riding a trend. They have momentum. These can be more volatile - they don’t have the floor of strong cash flow


0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -12%
Weak multi-year price returns
2Y Excs Rtn is -146%, 3Y Excs Rtn is -171%
Penny stock
Mkt Price is 0.5
1 Megatrend and thematic drivers
Megatrends include Precision Medicine, and Biotechnology & Genomics. Themes include Biopharmaceutical R&D, Personalized Diagnostics, Show more.
  Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -11 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -186%
2   Weak revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is -44%, Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -13%, Rev Chg QQuarterly Revenue Change % is -75%
3   Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -101%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -105%
4   Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -421%
5   High stock price volatility
Vol 12M is 208%
0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -12%
1 Megatrend and thematic drivers
Megatrends include Precision Medicine, and Biotechnology & Genomics. Themes include Biopharmaceutical R&D, Personalized Diagnostics, Show more.
2 Weak multi-year price returns
2Y Excs Rtn is -146%, 3Y Excs Rtn is -171%
3 Penny stock
Mkt Price is 0.5
4 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -11 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -186%
5 Weak revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is -44%, Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -13%, Rev Chg QQuarterly Revenue Change % is -75%
6 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -101%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -105%
7 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -421%
8 High stock price volatility
Vol 12M is 208%

Valuation, Metrics & Events

ISPC Stock


Why The Stock Moved


Qualitative Assessment

AI Generated Analysis | Feedback

The iSpecimen (ISPC) stock experienced a significant decline between August 31, 2025, and December 4, 2025. The price on August 31, 2025, was around $0.74. As of December 3, 2025, the price was $0.456, representing a decrease of approximately 38.38% from the August 31 price, which aligns closely with the user's stated -35.9% movement. Here are the key points for why iSpecimen (ISPC) stock moved by approximately -35.9% during the period from August 31, 2025, to December 4, 2025: 1. Continued Weak Financial Performance: Throughout the period, iSpecimen demonstrated deeply negative profit margins, including an EBIT margin of -187.5% and a profit margin of -172.51% as of September 14, 2025, indicating inefficient cost management and a challenging operating environment. Revenue figures were also lackluster, with a decline over the past three years at -16.44%. The company also reported a net loss of -$2.78 million for the last quarter, a 165.52% change from the quarter before, and an EBITDA of -$10.26 million as of December 2, 2025.

2. High Leverage and Low Liquidity: iSpecimen continued to face significant liquidity concerns, highlighted by a quick ratio of 0.1 and a current ratio of 0.2, along with a high leverage ratio of 9.7, indicating substantial debt exposure relative to equity as of September 14, 2025. This precarious liquidity situation likely contributed to investor caution.

Show more

Stock Movement Drivers

Return vs. Risk


Price Returns Compared

 202020212022202320242025Total [1]
Returns
ISPC Return---82%-64%-73%-84%-100%
Peers Return42%3%-9%-5%-14%33%43%
S&P 500 Return16%27%-19%24%23%16%112%

Monthly Win Rates [3]
ISPC Win Rate-50%17%33%33%30% 
Peers Win Rate40%33%32%28%25%53% 
S&P 500 Win Rate58%75%42%67%75%70% 

Max Drawdowns [4]
ISPC Max Drawdown---85%-67%-73%-84% 
Peers Max Drawdown-25%-12%-25%-25%-21%-10% 
S&P 500 Max Drawdown-31%-1%-25%-1%-2%-15% 


[1] Cumulative total returns since the beginning of 2020
[2] Peers: A, ATEC, CERS, BLLN, BNBX.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2025 data is for the year up to 12/3/2025 (YTD)

How Low Can It Go

Unique KeyEventISPCS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-97.8%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven4348.8%34.1%
2022 Inflation ShockTime to BreakevenTime to BreakevenNot Fully Recovered days464 days

Compare to A, ATEC, CERS, BLLN, BNBX


In The Past

iSpecimen's stock fell -97.8% during the 2022 Inflation Shock from a high on 11/29/2021. A -97.8% loss requires a 4348.8% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth over time.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About iSpecimen (ISPC)

Better Bets than iSpecimen (ISPC)

Latest Trefis Analyses

Title
0ARTICLES

Trade Ideas

Select past ideas related to ISPC. For more, see Trefis Trade Ideas.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
CRL_11142025_Dip_Buyer_FCFYield11142025CRLCharles River Laboratories InternationalDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
4.1%4.1%-3.7%
GDRX_11142025_Dip_Buyer_High_CFO_Margins_ExInd_DE11142025GDRXGoodRxDip BuyDB | CFO/Rev | Low D/EDip Buy with High Cash Flow Margins
Buying dips for companies with significant cash flows from operations and reasonable debt / market cap
-9.8%-9.8%-11.8%
ASTH_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025ASTHAstrana HealthDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
6.0%6.0%-5.5%
SGRY_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025SGRYSurgery PartnersDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
9.7%9.7%-1.4%
TFX_11072025_Dip_Buyer_FCFYield11072025TFXTeleflexDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
6.2%6.2%-5.1%
Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
CRL_11142025_Dip_Buyer_FCFYield11142025CRLCharles River Laboratories InternationalDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
4.1%4.1%-3.7%
GDRX_11142025_Dip_Buyer_High_CFO_Margins_ExInd_DE11142025GDRXGoodRxDip BuyDB | CFO/Rev | Low D/EDip Buy with High Cash Flow Margins
Buying dips for companies with significant cash flows from operations and reasonable debt / market cap
-9.8%-9.8%-11.8%
ASTH_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025ASTHAstrana HealthDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
6.0%6.0%-5.5%
SGRY_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025SGRYSurgery PartnersDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
9.7%9.7%-1.4%
TFX_11072025_Dip_Buyer_FCFYield11072025TFXTeleflexDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
6.2%6.2%-5.1%

Recent Active Movers

Recent Active Movers

More From Trefis

Peer Comparisons for iSpecimen

Peers to compare with:

Financials

ISPCAATECCERSBLLNBNBXMedian
NameiSpecimenAgilent .Alphatec Cerus BillionT.BNB Plus  
Mkt Price0.46149.2621.231.99102.763.1112.17
Mkt Cap0.042.43.20.4--1.8
Rev LTM66,788728199-4199
Op Inc LTM-111,444-74-9--13-11
FCF LTM-61,088-30--14-3
FCF 3Y Avg-91,308-112-15--10-10
CFO LTM-61,495354--134
CFO 3Y Avg-61,662-36-12--10-10

Growth & Margins

ISPCAATECCERSBLLNBNBXMedian
NameiSpecimenAgilent .Alphatec Cerus BillionT.BNB Plus  
Rev Chg LTM-43.8%4.5%27.1%13.0%--51.0%4.5%
Rev Chg 3Y Avg-13.3%0.8%31.8%8.3%--12.6%0.8%
Rev Chg Q-75.1%10.1%30.4%14.5%-34.3%14.5%
QoQ Delta Rev Chg LTM-26.7%2.4%6.7%3.5%-7.5%3.5%
Op Mgn LTM-186.3%21.3%-10.1%-4.8%--306.1%-10.1%
Op Mgn 3Y Avg-132.0%21.5%-21.8%-11.9%--170.3%-21.8%
QoQ Delta Op Mgn LTM-45.2%-0.1%3.8%1.3%-42.9%1.3%
CFO/Rev LTM-100.5%22.0%4.8%1.8%--301.5%1.8%
CFO/Rev 3Y Avg-72.1%24.6%-7.6%-7.5%--141.9%-7.6%
FCF/Rev LTM-104.8%16.0%-0.5%0.1%--313.1%-0.5%
FCF/Rev 3Y Avg-98.3%19.4%-21.7%-9.7%--147.0%-21.7%

Valuation

ISPCAATECCERSBLLNBNBXMedian
NameiSpecimenAgilent .Alphatec Cerus BillionT.BNB Plus  
Mkt Cap0.042.43.20.4--1.8
P/S0.44.93.01.5--2.3
P/EBIT-0.222.2-19.2-42.1---9.7
P/E-0.227.5-14.2-19.1---7.2
P/CFO-0.422.462.885.5--42.6
Total Yield-416.5%4.5%-7.0%-5.2%---6.1%
Dividend Yield0.0%0.8%0.0%0.0%--0.0%
FCF Yield 3Y Avg-185.7%3.7%-11.2%-5.1%---8.1%
D/E0.10.10.30.3--0.2
Net D/E-0.10.10.20.1--0.1

Returns

ISPCAATECCERSBLLNBNBXMedian
NameiSpecimenAgilent .Alphatec Cerus BillionT.BNB Plus  
1M Rtn-39.2%3.2%10.1%30.9%--8.5%3.2%
3M Rtn-32.2%19.4%33.5%51.9%--26.5%
6M Rtn-63.6%30.4%72.9%38.2%--34.3%
12M Rtn-89.0%8.0%112.3%12.4%--10.2%
3Y Rtn-98.5%-2.0%106.7%-52.0%---27.0%
1M Excs Rtn-39.2%3.2%10.1%31.0%--8.5%3.2%
3M Excs Rtn-37.3%11.1%22.9%44.3%--17.0%
6M Excs Rtn-78.3%15.7%58.2%23.5%--19.6%
12M Excs Rtn-102.9%-4.5%89.0%-6.0%---5.2%
3Y Excs Rtn-171.3%-72.6%50.7%-119.0%---95.8%

Financials

Price Behavior

Short Interest

Short Interest: As Of Date11142025
Short Interest: Shares Quantity67,653
Short Interest: % Change Since 10312025-53.3%
Average Daily Volume181,617
Days-to-Cover Short Interest1
Basic Shares Quantity2,496,860
Short % of Basic Shares2.7%

SEC Filings

Expand for More

Report DateFiling DateFiling
6302025814202510-Q 6/30/2025
3312025519202510-Q 3/31/2025
12312024414202510-K 12/31/2024
93020241107202410-Q 9/30/2024
6302024806202410-Q 6/30/2024
3312024507202410-Q 3/31/2024
12312023313202410-K 12/31/2023
93020231102202310-Q 9/30/2023
6302023802202310-Q 6/30/2023
3312023504202310-Q 3/31/2023
12312022321202310-K 12/31/2022
93020221108202210-Q 9/30/2022
6302022804202210-Q 6/30/2022
3312022510202210-Q 3/31/2022
12312021322202210-K 12/31/2021
93020211104202110-Q 9/30/2021