Helus Pharma (HELP)
Market Price (7/6/2026): $6.2 | Market Cap: $263.6 MilSector: Health Care | Industry: Biotechnology
Helus Pharma (HELP)
Market Price (7/6/2026): $6.2Market Cap: $263.6 MilSector: Health CareIndustry: Biotechnology
Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.
Cash is significant % of market capNet D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -74% Megatrend and thematic driversMegatrends include Precision Medicine, and Aging Population & Chronic Disease. Themes include Biopharmaceutical R&D, Targeted Therapies, Show more. | Weak multi-year price returns2Y Excs Rtn is -56%, 3Y Excs Rtn is -90% | Very low revenueRev LTMTotal Revenue or Sales, Last Twelve Months is 0 Not profitable at operating income levelOp Inc LTMOperating Income, Last Twelve Months is -115 Mil Yield minus risk free rate is negativeERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -49% Key risksHELP key risks include [1] the successful clinical development and manufacturing scale-up of its lead drug candidates HLP003 and HLP004, Show more. |
| Cash is significant % of market capNet D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -74% |
| Megatrend and thematic driversMegatrends include Precision Medicine, and Aging Population & Chronic Disease. Themes include Biopharmaceutical R&D, Targeted Therapies, Show more. |
| Weak multi-year price returns2Y Excs Rtn is -56%, 3Y Excs Rtn is -90% |
| Very low revenueRev LTMTotal Revenue or Sales, Last Twelve Months is 0 |
| Not profitable at operating income levelOp Inc LTMOperating Income, Last Twelve Months is -115 Mil |
| Yield minus risk free rate is negativeERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -49% |
| Key risksHELP key risks include [1] the successful clinical development and manufacturing scale-up of its lead drug candidates HLP003 and HLP004, Show more. |
Qualitative Assessment
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Helus Pharma (HELP) stock has gained about 30% since 3/31/2026 because of the following key factors:
1. Significant Advancement of Lead Candidate HLP003.
Helus Pharma's lead drug candidate, HLP003, for Major Depressive Disorder (MDD), showed substantial progress in its Phase 3 APPROACH trial, surpassing 88% enrollment by late June 2026 and remaining on track for topline data readout in the fourth quarter of 2026. This progress built on positive Phase 2 data, which demonstrated strong efficacy with an approximate 23-point reduction in the MADRS score from baseline at 12 months, alongside 100% response and 71% remission rates. The drug's FDA Breakthrough Therapy Designation further enhanced investor confidence in its potential.
2. Successful $50 Million Capital Raise.
The company strengthened its financial position by completing a $50 million underwritten public offering on June 25, 2026, with shares priced at $4.85 each. The proceeds from this offering are earmarked to support the execution of its second Phase 3 trial, EMBRACE, for HLP003, and to advance other pipeline programs, thereby reducing financing risk and providing capital for critical development milestones. This capital infusion, alongside a reported cash balance of $157.3 million as of the fiscal year ended March 31, 2026, improved liquidity and investor perception.
Show more
Helus Pharma (HELP) stock has gained about 30% since 3/31/2026 because of the following key factors:
1. Significant Advancement of Lead Candidate HLP003.
Helus Pharma's lead drug candidate, HLP003, for Major Depressive Disorder (MDD), showed substantial progress in its Phase 3 APPROACH trial, surpassing 88% enrollment by late June 2026 and remaining on track for topline data readout in the fourth quarter of 2026. This progress built on positive Phase 2 data, which demonstrated strong efficacy with an approximate 23-point reduction in the MADRS score from baseline at 12 months, alongside 100% response and 71% remission rates. The drug's FDA Breakthrough Therapy Designation further enhanced investor confidence in its potential.
2. Successful $50 Million Capital Raise.
The company strengthened its financial position by completing a $50 million underwritten public offering on June 25, 2026, with shares priced at $4.85 each. The proceeds from this offering are earmarked to support the execution of its second Phase 3 trial, EMBRACE, for HLP003, and to advance other pipeline programs, thereby reducing financing risk and providing capital for critical development milestones. This capital infusion, alongside a reported cash balance of $157.3 million as of the fiscal year ended March 31, 2026, improved liquidity and investor perception.
3. Positive Phase 2 Data for HLP004 in Generalized Anxiety Disorder.
Helus Pharma reported positive topline results from a Phase 2 signal detection study for HLP004 in Generalized Anxiety Disorder (GAD) in late June 2026, demonstrating an approximate 10-point improvement from baseline in the Hamilton Anxiety Rating Scale (HAM-A) on top of standard of care at six weeks. This promising data for a second key pipeline asset diversified the company's therapeutic potential and contributed to overall positive market sentiment.
4. Strong Analyst Endorsement and Price Targets.
Throughout the period, Helus Pharma received strong endorsements from Wall Street analysts. In April 2026, TD Cowen initiated coverage with a Buy rating and an $8 price target, citing the de-risked nature of the HLP003 Phase 3 program. Jefferies also initiated coverage with a Buy rating and a $22 price target, anticipating significant upside from upcoming catalysts in 2026. As of June 2026, the consensus among analysts was a "Strong Buy" with an average 12-month price target of $41.67, indicating substantial implied upside for the stock and bolstering investor confidence.
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Stock Movement Drivers
Fundamental Drivers
The 30.0% change in HELP stock from 3/31/2026 to 7/5/2026 was primarily driven by a 0.0% change in the company's Total Revenues ($ Mil).| (LTM values as of) | 3312026 | 7052026 | Change |
|---|---|---|---|
| Stock Price ($) | 4.80 | 6.24 | 30.0% |
| Change Contribution By: | |||
| Total Revenues ($ Mil) | 0 | 0 | 0.0% |
| P/S Multiple | ∞ | ∞ | 0.0% |
| Shares Outstanding (Mil) | 43 | 43 | 0.0% |
| Cumulative Contribution | 0.0% |
Market Drivers
3/31/2026 to 7/5/2026| Return | Correlation | |
|---|---|---|
| HELP | 30.0% | |
| Market (SPY) | 14.5% | 31.2% |
| Sector (XLV) | 11.7% | 29.2% |
Fundamental Drivers
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Market Drivers
12/31/2025 to 7/5/2026| Return | Correlation | |
|---|---|---|
| HELP | ||
| Market (SPY) | 9.5% | 39.2% |
| Sector (XLV) | 6.2% | 29.2% |
Fundamental Drivers
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Market Drivers
6/30/2025 to 7/5/2026| Return | Correlation | |
|---|---|---|
| HELP | ||
| Market (SPY) | 21.6% | 39.2% |
| Sector (XLV) | 23.1% | 29.2% |
Fundamental Drivers
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Market Drivers
6/30/2023 to 7/5/2026| Return | Correlation | |
|---|---|---|
| HELP | ||
| Market (SPY) | 74.0% | 39.2% |
| Sector (XLV) | 29.1% | 29.2% |
Price Returns Compared
| 2021 | 2022 | 2023 | 2024 | 2025 | 2026 | Total [1] | |
|---|---|---|---|---|---|---|---|
| Returns | |||||||
| HELP Return | - | - | - | - | - | -19% | -19% |
| Peers Return | -54% | 104% | 3% | 6% | 116% | 32% | 195% |
| S&P 500 Return | 27% | -19% | 24% | 23% | 16% | 9% | 99% |
Monthly Win Rates [3] | |||||||
| HELP Win Rate | - | - | - | - | - | 43% | |
| Peers Win Rate | 50% | 67% | 50% | 50% | 58% | 71% | |
| S&P 500 Win Rate | 75% | 42% | 67% | 75% | 67% | 43% | |
Max Drawdowns [4] | |||||||
| HELP Max Drawdown | - | - | - | - | - | - | |
| Peers Max Drawdown | -76% | -53% | -36% | -33% | -31% | -18% | |
| S&P 500 Max Drawdown | -5% | -25% | -10% | -8% | -19% | -9% | |
[1] Cumulative total returns since the beginning of 2021
[2] Peers: AXSM.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 7/2/2026 (YTD)
How Low Can It Go
HELP has limited trading history. Below is the Health Care sector ETF (XLV) in its place.
| Event | XLV | S&P 500 |
|---|---|---|
| 2025 US Tariff Shock | ||
| % Loss | -11.7% | -18.8% |
| % Gain to Breakeven | 13.3% | 23.1% |
| Time to Breakeven | 142 days | 79 days |
| 2022 Inflation Shock & Fed Tightening | ||
| % Loss | -13.8% | -24.5% |
| % Gain to Breakeven | 15.9% | 32.4% |
| Time to Breakeven | 166 days | 427 days |
| 2020 COVID-19 Crash | ||
| % Loss | -27.9% | -33.7% |
| % Gain to Breakeven | 38.8% | 50.9% |
| Time to Breakeven | 77 days | 140 days |
| Q4 2018 Fed Policy Error / Growth Scare | ||
| % Loss | -15.0% | -19.2% |
| % Gain to Breakeven | 17.6% | 23.8% |
| Time to Breakeven | 191 days | 105 days |
| 2015-2016 China Devaluation / Global Growth Scare | ||
| % Loss | -15.9% | -12.2% |
| % Gain to Breakeven | 18.9% | 13.9% |
| Time to Breakeven | 165 days | 62 days |
| 2011 US Debt Ceiling Crisis & European Contagion | ||
| % Loss | -15.8% | -17.9% |
| % Gain to Breakeven | 18.8% | 21.8% |
| Time to Breakeven | 153 days | 123 days |
In The Past
State Street Health Care Select Sector SPDR ETF's stock fell -11.7% during the 2025 US Tariff Shock. Such a loss loss requires a 13.3% gain to breakeven.
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HELP has limited trading history. Below is the Health Care sector ETF (XLV) in its place.
| Event | XLV | S&P 500 |
|---|---|---|
| 2020 COVID-19 Crash | ||
| % Loss | -27.9% | -33.7% |
| % Gain to Breakeven | 38.8% | 50.9% |
| Time to Breakeven | 77 days | 140 days |
| 2008-2009 Global Financial Crisis | ||
| % Loss | -37.9% | -53.4% |
| % Gain to Breakeven | 61.1% | 114.4% |
| Time to Breakeven | 767 days | 1085 days |
In The Past
State Street Health Care Select Sector SPDR ETF's stock fell -11.7% during the 2025 US Tariff Shock. Such a loss loss requires a 13.3% gain to breakeven.
Preserve Wealth
Limiting losses and compounding gains is essential to preserving wealth.
Asset Allocation
Actively managed asset allocation strategies protect wealth. Learn more.
About Helus Pharma (HELP)
Helus Pharma, trading under the symbol HELP, is a biopharmaceutical company dedicated to developing psychedelic-based therapeutics. The company focuses on leveraging novel compounds to address significant unmet needs in mental health and neurological conditions, positioning itself within the innovative landscape of psychedelic medicine.
The company's development pipeline features several key drug candidates. CYB003 is a deuterated psilocybin analog being developed for the treatment of major depressive and alcohol use disorders. Another prominent candidate, CYB004, is a deuterated dimethyltryptamine aimed at treating anxiety disorders. Additionally, Helus Pharma is exploring CYB005, a discovery-phase phenethylamine derivative, for its potential applications in neuroinflammation and various psychiatric conditions.
Beyond its pharmaceutical compounds, Helus Pharma also offers EMBARK, a proprietary psychedelic-assisted psychotherapy. The company primarily serves the healthcare market, with a focus on patients suffering from conditions such as depression, anxiety, alcohol use disorder, and other complex psychiatric and neuroinflammatory disorders. Its market encompasses the broader biopharmaceutical sector specializing in advanced mental health treatments.
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- Moderna for psychedelic medicine.
- A specialized Eli Lilly for psychedelic mental health treatments.
- An early Amgen, but for psychedelic therapeutics.
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- CYB003: A deuterated psilocybin analog to treat major depressive and alcohol use disorders.
- CYB004: A deuterated dimethyltryptamine for treating anxiety disorders.
- CYB005: A discovery-phase phenethylamine derivative to treat neuroinflammation and psychiatric conditions.
- EMBARK: A proprietary psychedelic-assisted psychotherapy program.
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Note: The company described in the background is Cybin Inc. (symbol: CYBN), a biopharmaceutical company developing psychedelic-based therapeutics. The request specified "Helus Pharma" (symbol: HELP). This response is based on the company description provided for Cybin Inc., assuming it is the intended subject.
As Cybin Inc. is a biopharmaceutical company with its product pipeline (CYB003, CYB004, CYB005, and EMBARK) currently in clinical development stages, it does not yet have major commercial customers in the traditional sense of selling approved products. Upon potential market approval and commercialization, its major customers would primarily be other companies and institutions within the healthcare sector. These would include:
- Hospitals and Integrated Healthcare Networks: These institutions would purchase and administer Cybin's approved therapeutics and offer psychedelic-assisted psychotherapy for conditions such as major depressive disorder, alcohol use disorder, and anxiety disorders to their patients.
- Specialized Psychiatric and Addiction Treatment Centers: Private and public clinics focused on mental health and substance abuse treatment would be key adopters of Cybin's innovative therapies, integrating them into their treatment protocols.
- Pharmaceutical Distributors and Wholesalers: These companies would serve as intermediaries, purchasing the therapeutics from Cybin Inc. and managing their distribution to various healthcare providers and institutions.
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The key risks to Helus Pharma (trading under the symbol HELP), which is Cybin Inc. doing business as Helus Pharma, are primarily associated with the biopharmaceutical nature of its psychedelic-based therapeutics development.
- Clinical Development and Regulatory Approval Risk: Helus Pharma's success is highly dependent on the successful completion of clinical trials for its pipeline candidates, including CYB003 for major depressive and alcohol use disorders, CYB004 for anxiety disorders, and CYB005 for neuroinflammation and psychiatric conditions. The failure of any of these trials, or significant delays in their progress, could severely impact the company's financial health and future prospects. Furthermore, obtaining regulatory approvals for psychedelic-based therapeutics presents unique challenges due to the historical context and stringent regulatory scrutiny associated with these compounds.
- Intellectual Property Protection: As a biopharmaceutical company developing novel compounds like deuterated psilocybin and dimethyltryptamine analogs, Helus Pharma's intellectual property (IP) is critical to its business. The ability to secure, maintain, and defend patents for its drug candidates and therapeutic approaches is essential for market exclusivity and competitive advantage. Challenges to its existing patents, or the inability to obtain new patent protection, could allow competitors to develop similar products, eroding Helus Pharma's market share and profitability.
- Market Acceptance and Commercialization Challenges: Even upon successful regulatory approval, Helus Pharma faces risks related to the broad market acceptance and commercialization of its psychedelic-based therapeutics and associated psychotherapy programs like EMBARK. Overcoming the societal stigma historically associated with psychedelics, securing favorable reimbursement policies from payers, and gaining widespread adoption by healthcare providers and patients will be crucial for commercial success. Competition from existing and emerging treatments for mental health and alcohol use disorders could also limit its market penetration.
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Helus Pharma (trading under symbol HELP), also known as Cybin Inc., is a biopharmaceutical company focused on developing psychedelic-based therapeutics for various mental health conditions. Below are the estimated addressable market sizes for their main product areas:
-
CYB003 (Deuterated psilocybin analog for Major Depressive Disorder and Alcohol Use Disorders):
- For Major Depressive Disorder, the global market size was estimated at approximately USD 6.84 billion in 2024 and is projected to reach USD 14.57 billion by 2033.
- For Alcohol Use Disorders, the global market was valued at USD 1.28 billion in 2024 and is expected to grow to USD 1.88 billion by 2030.
-
CYB004 (Deuterated dimethyltryptamine for Anxiety Disorders):
- The global anxiety disorder treatment market was estimated at USD 12.89 billion in 2024 and is projected to reach USD 17.57 billion by 2032.
-
CYB005 (Discovery-phase phenethylamine derivative for Neuroinflammation and Psychiatric Conditions):
- For Neuroinflammation, the global Neuroregeneration Therapy Market was estimated at USD 15.24 billion in 2025 and is projected to reach USD 41.98 billion by 2033. Additionally, the global anti-inflammatory therapeutics market size was calculated at USD 110.17 billion in 2025, projected to reach around USD 165.92 billion by 2035.
- For Psychiatric Conditions (broadly), the global mental health market size was approximately USD 490.91 billion in 2025 and is expected to reach around USD 682.51 billion by 2035. The global central nervous system (CNS) therapeutics market, which includes psychiatric disorders, was estimated at USD 138.59 billion in 2025 and is projected to reach USD 273.32 billion by 2033.
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Peer Comparisons
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Financials
| Median | |
|---|---|
| Name | |
| Mkt Price | 125.28 |
| Mkt Cap | 6.4 |
| Rev LTM | 354 |
| Op Inc LTM | -146 |
| FCF LTM | -92 |
| FCF 3Y Avg | -102 |
| CFO LTM | -91 |
| CFO 3Y Avg | -102 |
Growth & Margins
| Median | |
|---|---|
| Name | |
| Rev Chg LTM | 63.9% |
| Rev Chg 3Y Avg | 69.9% |
| Rev Chg Q | 57.4% |
| QoQ Delta Rev Chg LTM | 10.9% |
| Op Inc Chg LTM | 4.4% |
| Op Inc Chg 3Y Avg | -28.6% |
| Op Mgn LTM | -24.9% |
| Op Mgn 3Y Avg | -59.3% |
| QoQ Delta Op Mgn LTM | 1.6% |
| CFO/Rev LTM | -10.0% |
| CFO/Rev 3Y Avg | -38.0% |
| FCF/Rev LTM | -10.0% |
| FCF/Rev 3Y Avg | -38.2% |
Price Behavior
| 1M | 2M | 3M | 6M | 1Y | 3Y | |
|---|---|---|---|---|---|---|
| Beta | 1.22 | 1.43 | 2.09 | 0.06 | 0.41 | 0.58 |
| Up Beta | -0.71 | 0.60 | 1.87 | 1.00 | 1.25 | 0.77 |
| Down Beta | 2.89 | 1.63 | 1.29 | -0.82 | 0.91 | 0.34 |
| Up Capture | 398% | 238% | 320% | 448% | 197% | 19% |
| Bmk +ve Days | 11 | 24 | 40 | 67 | 140 | 429 |
| Stock +ve Days | 12 | 20 | 30 | 55 | 55 | 55 |
| Down Capture | -88% | 106% | 219% | 242% | 160% | 86% |
| Bmk -ve Days | 10 | 17 | 23 | 58 | 112 | 321 |
| Stock -ve Days | 8 | 19 | 28 | 61 | 61 | 61 |
[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
| Annualized Return | Annualized Volatility | Sharpe Ratio | Correlation with HELP | |
|---|---|---|---|---|
| HELP | -19.3% | 91.3% | -0.04 | - |
| Sector ETF (XLV) | 21.4% | 15.6% | 1.05 | 29.2% |
| Equity (SPY) | 21.7% | 12.5% | 1.29 | 39.2% |
| Gold (GLD) | 23.1% | 27.7% | 0.73 | 18.5% |
| Commodities (DBC) | 21.3% | 18.6% | 0.90 | -13.1% |
| Real Estate (VNQ) | 13.6% | 13.8% | 0.68 | 20.9% |
| Bitcoin (BTCUSD) | -42.0% | 42.7% | -1.15 | 25.3% |
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Based On 5-Year Data
| Annualized Return | Annualized Volatility | Sharpe Ratio | Correlation with HELP | |
|---|---|---|---|---|
| HELP | -4.2% | 91.3% | -0.04 | - |
| Sector ETF (XLV) | 7.2% | 14.9% | 0.30 | 29.2% |
| Equity (SPY) | 13.3% | 17.1% | 0.60 | 39.2% |
| Gold (GLD) | 17.9% | 18.3% | 0.79 | 18.5% |
| Commodities (DBC) | 6.9% | 19.5% | 0.25 | -13.1% |
| Real Estate (VNQ) | 3.1% | 18.9% | 0.06 | 20.9% |
| Bitcoin (BTCUSD) | 12.2% | 53.8% | 0.41 | 25.3% |
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Based On 10-Year Data
| Annualized Return | Annualized Volatility | Sharpe Ratio | Correlation with HELP | |
|---|---|---|---|---|
| HELP | -2.1% | 91.3% | -0.04 | - |
| Sector ETF (XLV) | 10.6% | 16.6% | 0.52 | 29.2% |
| Equity (SPY) | 15.4% | 18.0% | 0.73 | 39.2% |
| Gold (GLD) | 12.1% | 16.1% | 0.61 | 18.5% |
| Commodities (DBC) | 5.7% | 18.0% | 0.25 | -13.1% |
| Real Estate (VNQ) | 5.5% | 20.7% | 0.23 | 20.9% |
| Bitcoin (BTCUSD) | 59.0% | 66.2% | 0.99 | 25.3% |
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Earnings Returns History
Updated 6/3/2026| Forward Returns | |||
|---|---|---|---|
| Earnings Date | 1D Returns | 5D Returns | 21D Returns |
| SUMMARY STATS | |||
| # Positive | 0 | 0 | 0 |
| # Negative | 0 | 0 | 0 |
| Median Positive | |||
| Median Negative | |||
| Max Positive | |||
| Max Negative | |||
| Forward Returns | |||
|---|---|---|---|
| Earnings Date | 1D Returns | 5D Returns | 21D Returns |
| SUMMARY STATS | |||
| # Positive | 0 | 0 | 0 |
| # Negative | 0 | 0 | 0 |
| Median Positive | |||
| Median Negative | |||
| Max Positive | |||
| Max Negative | |||
SEC Filings
Expand for More| Report Date | Filing Date | Filing |
|---|---|---|
| 12/31/2025 | 02/13/2026 | 6-K |
| 09/30/2025 | 11/13/2025 | 6-K |
| 06/30/2025 | 08/14/2025 | 6-K |
| 03/31/2025 | 07/01/2025 | 40-F |
| 12/31/2024 | 02/11/2025 | 6-K |
| 09/30/2024 | 11/13/2024 | 6-K |
| 06/30/2024 | 08/08/2024 | 6-K |
| 03/31/2024 | 06/26/2024 | 40-F |
| 12/31/2023 | 02/14/2024 | 6-K |
| 09/30/2023 | 11/15/2023 | 6-K |
| 06/30/2023 | 08/14/2023 | 6-K |
| 03/31/2023 | 06/27/2023 | 40-F |
| 12/31/2022 | 02/14/2023 | 6-K |
| 09/30/2022 | 11/15/2022 | 6-K |
| 06/30/2022 | 08/08/2022 | 6-K |
| 03/31/2022 | 06/22/2022 | 40-F |
| Report Date | Filing Date | Filing |
|---|---|---|
| 12/31/2025 | 02/13/2026 | 6-K |
| 09/30/2025 | 11/13/2025 | 6-K |
| 06/30/2025 | 08/14/2025 | 6-K |
| 03/31/2025 | 07/01/2025 | 40-F |
| 12/31/2024 | 02/11/2025 | 6-K |
| 09/30/2024 | 11/13/2024 | 6-K |
| 06/30/2024 | 08/08/2024 | 6-K |
| 03/31/2024 | 06/26/2024 | 40-F |
| 12/31/2023 | 02/14/2024 | 6-K |
| 09/30/2023 | 11/15/2023 | 6-K |
| 06/30/2023 | 08/14/2023 | 6-K |
| 03/31/2023 | 06/27/2023 | 40-F |
| 12/31/2022 | 02/14/2023 | 6-K |
| 09/30/2022 | 11/15/2022 | 6-K |
| 06/30/2022 | 08/08/2022 | 6-K |
| 03/31/2022 | 06/22/2022 | 40-F |
| 12/31/2021 | 02/10/2022 | 6-K |
| 09/30/2021 | 11/15/2021 | 6-K |
| 06/30/2021 | 08/16/2021 | 6-K |
Industry Resources
External Quote Links
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| FinViz |
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