Market Movers | Winners: NAUT, QSI, RHI | Losers: LKQ, CORT, PHAT
On Friday, October 23, the S&P 500 fell 0.5%, the Nasdaq-100 was flat and the Dow Jones Industrial Average dropped 1.2%. Over the past week the S&P 500 is down 0.5%, and over the past month it is down 1.0%.
Within the Trefis coverage universe, 1,508 stocks rose and 2,580 fell. Nautilus Biotechnology (NAUT) gained 24.6% to lead the day, while LKQ fell 22.5%, the weakest showing.

Friday’s Market Winners
The 10 US-listed stocks in the Trefis coverage universe worth at least $300 million with the highest returns on Friday:
| # | Ticker | Company Name | 1-D Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | NAUT | Nautilus Biotechnology | 24.6% | 66.2% |
| 2 | QSI | Quantum-Si | 21.7% | 27.3% |
| 3 | RHI | Robert Half | 21.7% | 79.4% |
| 4 | NN | NextNav | 9.4% | -39.4% |
| 5 | ENVX | Enovix | 9.4% | -61.8% |
| 6 | AVBP | ArriVent BioPharma | 9.4% | 4.4% |
| 7 | NTSK | Netskope | 9.4% | 38.4% |
| 8 | THRM | Gentherm | 9.4% | -16.7% |
| 9 | VG | Venture Global | 9.3% | 106.4% |
| 10 | CART | Maplebear | 9.2% | 25.5% |
Friday’s Market Losers
And the 10 US-listed stocks in the Trefis coverage universe worth at least $300 million with the lowest returns on Friday:
| # | Ticker | Company Name | 1-D Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | LKQ | LKQ | -22.5% | -40.4% |
| 2 | CORT | Corcept Therapeutics | -20.1% | 146.7% |
| 3 | PHAT | Phathom Pharmaceuticals | -18.1% | -65.4% |
| 4 | TNGX | Tango Therapeutics | -16.4% | 163.4% |
| 5 | WGS | GeneDx | -16.4% | -56.8% |
| 6 | USCB | USCB Financial | -12.1% | 10.6% |
| 7 | EIKN | Eikon Therapeutics | -11.9% | n/a |
| 8 | BE | Bloom Energy | -11.2% | 122.5% |
| 9 | SLM | SLM | -10.8% | -27.0% |
| 10 | STC | Stewart Information Services | -10.5% | -35.7% |
For A Few Names, Friday Extended A Monthly Trend
Nautilus Biotechnology (NAUT) appears on both the one-day and one-month winners lists. It rose 24.6% on Friday and is up 227.1% over the past month; excluding Friday, it had already gained 162.5% over the other sessions.
Quantum-Si (QSI) added to a longer run: after Friday’s 21.7% gain, the stock is up 78.3% over the past month, and it was already up 46.5% before Friday.
Movers Over The Last Week
Widening the window to five trading days, these are the strongest and weakest names in the Trefis coverage universe:
Winners
| # | Ticker | Company Name | 1-W Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | NAUT | Nautilus Biotechnology | 57.3% | 66.2% |
| 2 | BRZE | Braze | 56.4% | 33.8% |
| 3 | MYGN | Myriad Genetics | 46.2% | -5.4% |
| 4 | RHI | Robert Half | 37.7% | 79.4% |
| 5 | IRON | Disc Medicine | 31.1% | -6.2% |
| 6 | TRAX | First Tracks Biotherapeutics | 27.8% | n/a |
| 7 | NTSK | Netskope | 27.8% | 38.4% |
| 8 | MANE | Veradermics | 27.5% | n/a |
| 9 | APPN | Appian | 27.2% | 47.8% |
| 10 | AVBP | ArriVent BioPharma | 26.1% | 4.4% |
Losers
| # | Ticker | Company Name | 1-W Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | AVTX | Avalo Therapeutics | -38.5% | -61.8% |
| 2 | AVEX | AEVEX | -29.5% | n/a |
| 3 | NVEC | NVE | -26.7% | 26.8% |
| 4 | KALU | Kaiser Aluminum | -26.7% | -4.6% |
| 5 | CRS | Carpenter Technology | -24.5% | -9.4% |
| 6 | FPS | Forgent Power Solutions | -23.5% | n/a |
| 7 | CORT | Corcept Therapeutics | -22.1% | 146.7% |
| 8 | LKQ | LKQ | -21.6% | -40.4% |
| 9 | SECZ | Securitize | -20.9% | n/a |
| 10 | FCFS | FirstCash | -19.7% | 9.1% |
Movers Over The Last Month
And over the last 21 trading days, the strongest and weakest names in the Trefis coverage universe:
Winners
| # | Ticker | Company Name | 1-M Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | NAUT | Nautilus Biotechnology | 227.1% | 66.2% |
| 2 | BMBL | Bumble | 122.4% | 66.9% |
| 3 | BRZE | Braze | 86.0% | 33.8% |
| 4 | QSI | Quantum-Si | 78.3% | 27.3% |
| 5 | FIGS | FIGS | 61.7% | 77.8% |
| 6 | HPK | HighPeak Energy | 51.2% | 144.1% |
| 7 | DXC | DXC Technology | 48.8% | 9.8% |
| 8 | TTAN | ServiceTitan | 45.1% | -18.3% |
| 9 | RXO | RXO | 44.3% | 127.5% |
| 10 | KSS | Kohl’s | 42.6% | 23.4% |
Losers
| # | Ticker | Company Name | 1-M Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | CIFR | Cipher Digital | -56.1% | -46.2% |
| 2 | AVTX | Avalo Therapeutics | -55.9% | -61.8% |
| 3 | EMAT | Evolution Metals & Technologies | -55.5% | n/a |
| 4 | SECZ | Securitize | -52.8% | n/a |
| 5 | FMC | FMC | -46.9% | -62.8% |
| 6 | EOSE | Eos Energy Enterprises | -46.7% | -84.9% |
| 7 | RIOT | Riot Platforms | -46.6% | -1.1% |
| 8 | INDI | Indie Semiconductor | -46.6% | -53.8% |
| 9 | CBRS | Cerebras Systems | -46.3% | n/a |
| 10 | GEMI | Gemini Space Station | -45.8% | -69.2% |
Volatility Is The Cost Of Owning Stocks. Concentration Makes It A Bill
Every name on these lists made a move big enough to notice. A diversified holder reads that as noise; a concentrated holder feels it as real money. The difference is not the stock, it is the portfolio around it.
Building that portfolio is what the Trefis High Quality (HQ) Portfolio does: roughly 30 businesses with the cash generation and balance-sheet strength to absorb bad days, selected and rebalanced by rules. It has a track record of outpacing a benchmark that combines the S&P 500, the S&P MidCap 400, and the Russell 2000. Let the movers list remind you why diversification exists.