Market Movers | Winners: VKTX, INDP, MAZE | Losers: XNDU, EVER, CLDX
Some stocks show enduring strength or weakness even when the broader market stands still.
Indaptus Therapeutics (INDP) has gained +209.3% over the last month. That move stands out against a backdrop of major indexes moving sideways, with the S&P 500 returning 0.0% on the day, the Dow Jones Industrial Average returning -0.4%, and the Nasdaq-100 returning +0.8%.
The key question is whether the day’s biggest moves are isolated events or part of a larger trend. The lists of the day’s largest percentage changes follow.
Tuesday’s Market Winners
The 10 US-listed stocks in the Trefis coverage universe with the highest returns on the last trading day:
| # | Ticker | Company Name | 1-D Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | VKTX | Viking Therapeutics | 35.7% | 16.1% |
| 2 | INDP | Indaptus Therapeutics | 29.1% | 37.1% |
| 3 | MAZE | Maze Therapeutics | 26.8% | -31.5% |
| 4 | BFLY | Butterfly Network | 22.0% | 161.3% |
| 5 | VICR | Vicor | 19.8% | 144.8% |
| 6 | CD | Chaince Digital | 18.9% | -6.9% |
| 7 | DNA | Ginkgo Bioworks | 17.4% | 12.8% |
| 8 | BALY | Ballys | 16.6% | -25.5% |
| 9 | SGRY | Surgery Partners | 15.7% | 2.3% |
| 10 | INOD | Innodata | 14.6% | 37.3% |
Tuesday’s Market Losers
And the 10 US-listed stocks in the Trefis coverage universe with the lowest returns:
| # | Ticker | Company Name | 1-D Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | XNDU | Xanadu Quantum Technologies | -21.6% | n/a |
| 2 | EVER | EverQuote | -14.4% | -27.6% |
| 3 | CLDX | Celldex Therapeutics | -11.6% | 23.4% |
| 4 | GSHD | Goosehead Insurance | -11.5% | -37.9% |
| 5 | QNST | QuinStreet | -11.5% | 6.3% |
| 6 | AESI | Atlas Energy Solutions | -9.6% | 27.4% |
| 7 | PLNT | Planet Fitness | -9.5% | -60.7% |
| 8 | NUAI | New Era Energy & Digital | -8.8% | 138.1% |
| 9 | NKTR | Nektar Therapeutics | -8.8% | 44.2% |
| 10 | CAR | Avis Budget | -8.1% | -16.0% |
Are these moves just one-day noise?
Several names show moves that have been building for weeks. The strength in Indaptus Therapeutics (INDP) is not a one-day event; excluding today, it still gained +139.5% over the other sessions making up its monthly return. On the other side, the weakness in Xanadu Quantum Technologies (XNDU) has been building for weeks. The stock still lost 32.7% over the other sessions in its one-month window. For context on the business, Xanadu’s revenue grew 139.6% over the last twelve months.
Movers Over The Last Week
Widening the window to five trading days, these are the strongest and weakest names in the Trefis coverage universe:
Winners
| # | Ticker | Company Name | 1-W Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | CYPH | Cypherpunk Technologies | 68.0% | 221.6% |
| 2 | CD | Chaince Digital | 54.7% | -6.9% |
| 3 | VICR | Vicor | 45.9% | 144.8% |
| 4 | ALAB | Astera Labs | 43.9% | 118.5% |
| 5 | GRAL | GRAIL | 43.0% | 26.8% |
| 6 | FWDI | Forward Industries | 41.4% | 30.1% |
| 7 | GEMI | Gemini Space Station | 36.6% | -40.0% |
| 8 | VKTX | Viking Therapeutics | 36.4% | 16.1% |
| 9 | ORBS | Eightco | 36.1% | -32.4% |
| 10 | ABSI | Absci | 34.9% | 206.9% |
Losers
| # | Ticker | Company Name | 1-W Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | XENE | Xenon Pharmaceuticals | -30.5% | -12.8% |
| 2 | XNDU | Xanadu Quantum Technologies | -25.9% | n/a |
| 3 | ALHC | Alignment Healthcare | -23.0% | -59.5% |
| 4 | GSHD | Goosehead Insurance | -22.9% | -37.9% |
| 5 | FLNC | Fluence Energy | -21.8% | -63.2% |
| 6 | EVER | EverQuote | -20.1% | -27.6% |
| 7 | RSI | Rush Street Interactive | -18.6% | 9.2% |
| 8 | MTDR | Matador Resources | -17.9% | 24.9% |
| 9 | SM | SM Energy | -17.8% | 85.3% |
| 10 | CTEV | Claritev | -17.1% | -31.1% |
Movers Over The Last Month
And over the last 21 trading days, the strongest and weakest names in the Trefis coverage universe:
Winners
| # | Ticker | Company Name | 1-M Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | INDP | Indaptus Therapeutics | 209.3% | 37.1% |
| 2 | CYPH | Cypherpunk Technologies | 162.7% | 221.6% |
| 3 | BRR | ProCap Financial | 89.3% | 15.3% |
| 4 | FWDI | Forward Industries | 67.3% | 30.1% |
| 5 | TTRX | Turn Therapeutics | 61.6% | 288.1% |
| 6 | SDGR | Schrodinger | 55.8% | 71.7% |
| 7 | CAPR | Capricor Therapeutics | 48.5% | -67.6% |
| 8 | OKTA | OKTA | 45.5% | 127.4% |
| 9 | NUAI | New Era Energy & Digital | 43.7% | 138.1% |
| 10 | ACVA | ACV Auctions | 40.6% | 30.3% |
Losers
| # | Ticker | Company Name | 1-M Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | ALMS | Alumis | -66.4% | -16.9% |
| 2 | XNDU | Xanadu Quantum Technologies | -47.2% | n/a |
| 3 | SWMR | Swarmer | -46.7% | n/a |
| 4 | RARE | Ultragenyx Pharmaceutical | -39.5% | -32.1% |
| 5 | ALHC | Alignment Healthcare | -39.3% | -59.5% |
| 6 | KRMN | Karman | -37.3% | -54.2% |
| 7 | GSHD | Goosehead Insurance | -36.9% | -37.9% |
| 8 | FLNC | Fluence Energy | -35.9% | -63.2% |
| 9 | XENE | Xenon Pharmaceuticals | -35.7% | -12.8% |
| 10 | TTAN | ServiceTitan | -35.1% | -42.2% |
How should a disciplined investor use these lists?
The tables of winners and losers shown earlier are a map of attention and volatility, not a set of instructions. A large percentage move in either direction is simply information. It signals that something has changed perceptions of a company’s risk or opportunity. The disciplined next step is not to chase the move, but to investigate the business behind it.
Either side of these lists can be a lead worth following, with the same follow-up question: does the business back the move? For the winners, our Guidance Momentum screen tracks which companies raised their own forward numbers. For the losers, our Buy the Dip screen flags which marked-down names still have the fundamentals to recover.
Today’s Winner Is Tomorrow’s Loser Often Enough
The movers list is the most honest picture of single-stock risk the market prints each day: the same volatility that makes the winners column also fills the losers column, and no one reliably knows which side a stock lands on next.
That is the case for owning a disciplined basket instead of chasing the tape. The Trefis High Quality (HQ) Portfolio holds roughly 30 businesses selected for consistent cash generation, strong margins, and resilient balance sheets, sized and rebalanced with rules. It has a track record of outpacing a benchmark that combines the S&P 500, the S&P MidCap 400, and the Russell 2000. Watch the movers for information; let the portfolio do the compounding.