Sangamo Therapeutics (SGMO)
Market Price (9/18/2025): $0.53 | Market Cap: $136.2 MilSector: Health Care | Industry: Biotechnology
Sangamo Therapeutics (SGMO)
Market Price (9/18/2025): $0.53Market Cap: $136.2 MilSector: Health CareIndustry: Biotechnology
Investment Highlights
Cash is significant % of market capNet D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -11% | Weak multi-year price returns2Y Excs Rtn is -99%, 3Y Excs Rtn is -152% | Penny stockMkt Price is 0.5 |
Strong revenue growthRev Chg LTMRevenue Change % Last Twelve Months (LTM) is 566% | Not profitable at operating income levelOp Inc LTMOperating Income, Last Twelve Months is -63 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -77% | |
Valuation becoming less expensiveP/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is -54% | Not cash flow generativeCFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -44%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -44% | |
Yield minus risk free rate is negativeERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -53% | ||
High stock price volatilityVol 12M is 133% |
Cash is significant % of market capNet D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -11% |
Strong revenue growthRev Chg LTMRevenue Change % Last Twelve Months (LTM) is 566% |
Valuation becoming less expensiveP/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is -54% |
Weak multi-year price returns2Y Excs Rtn is -99%, 3Y Excs Rtn is -152% |
Penny stockMkt Price is 0.5 |
Not profitable at operating income levelOp Inc LTMOperating Income, Last Twelve Months is -63 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -77% |
Not cash flow generativeCFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -44%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -44% |
Yield minus risk free rate is negativeERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -53% |
High stock price volatilityVol 12M is 133% |
Market Valuation
9/18/25 | 2024 | 2023 | 2022 | 2021 | |
---|---|---|---|---|---|
Share Price CYE | $0.53 | $1.02 | $0.54 | $3.14 | $7.50 |
Market Cap CYE ($ Mil) | 136.2 | 214.5 | 96.5 | 517.6 | 1,093.1 |
Total Debt ($ Mil) | 23.5 | 30.6 | 38.1 | 43.1 | 48.1 |
Total Cash ($ Mil) | 38.3 | 41.9 | 81.0 | 277.6 | 376.5 |
Enterprise Value ($ Mil) | 121.3 | 245.1 | 134.6 | 560.7 | 1,141.2 |
Valuation Ratios | |||||
P/S TTM | 1.7 | 3.6 | 0.5 | 4.3 | 9.8 |
P/EBIT TTM | -2.2 | -2.1 | -0.8 | -2.4 | -5.9 |
P/E TTM | -2.1 | -2.1 | -0.4 | -2.5 | -6.1 |
Sector Ratios | |||||
P/S TTM (Sector) | 3.8 | 3.6 | 4.1 | 4.5 | 7.3 |
P/EBIT TTM (Sector) | -1.6 | -1.3 | -1.4 | -1.3 | -2.9 |
P/E TTM (Sector) | -1.8 | -1.5 | -1.5 | -1.3 | -2.9 |
9/18/25 | 2024 | 2023 | |
---|---|---|---|
Share Price CYE | $0.53 | $1.02 | $0.54 |
Market Cap CYE ($ Mil) | 136.2 | 214.5 | 96.5 |
Total Debt ($ Mil) | 23.5 | 30.6 | 38.1 |
Total Cash ($ Mil) | 38.3 | 41.9 | 81.0 |
Enterprise Value ($ Mil) | 121.3 | 245.1 | 134.6 |
Valuation Ratios | |||
P/S TTM | 1.7 | 3.6 | 0.5 |
P/EBIT TTM | -2.2 | -2.1 | -0.8 |
P/E TTM | -2.1 | -2.1 | -0.4 |
Sector Ratios | |||
P/S TTM (Sector) | 3.8 | 3.6 | 4.1 |
P/EBIT TTM (Sector) | -1.6 | -1.3 | -1.4 |
P/E TTM (Sector) | -1.8 | -1.5 | -1.5 |
Business Description
Sangamo Therapeutics, Inc., a clinical-stage biotechnology company, focuses on translating science into genomic medicines that transform patients' lives using platform technologies in gene therapy, cell therapy, genome editing, and genome regulation. The company offers zinc finger protein (ZFP), a technology platform for making zinc finger nucleases, which are proteins used in modifying DNA sequences by adding or knocking out specific genes; and ZFP transcription factors proteins used in increasing or decreasing gene expression. It develops SB-525, which is in Phase III AFFINE clinical trial for the treatment of hemophilia A; ST-920, a gene therapy, which is in Phase I/II STAAR clinical trials for the treatment of Fabry disease; and SAR445136, a cell therapy, which is in Phase I/II PRECIZN-1 clinical trials for the treatment of sickle cell disease.
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Price Returns Compared
Expand for Detailed View2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total [1] | |
---|---|---|---|---|---|---|---|
Returns | |||||||
SGMO Return | 86% | -52% | -58% | -83% | 88% | -50% | -94% |
Peers Return | 43% | 25% | 6% | 32% | 20% | 22% | 267% |
S&P 500 Return | 16% | 27% | -19% | 24% | 23% | 12% | 104% |
[1] Cumulative total returns since the beginning of 2020
[2] Peers: PTGX, ABBV, AMGN, GILD, VRTX. See SGMO Returns vs. Peers.
[3] 2025 data is for the year up to 9/17/2025 (YTD)
Latest Trefis Analyses
Research & Analysis
Invest in Strategies
Wealth Management
Peer Comparisons for Sangamo Therapeutics
Financials
Median | |
---|---|
Name | |
Mkt Price | 166.53 |
Mkt Cap | 119.6 |
Rev LTM | 20,140 |
Op Inc LTM | 4,108 |
FCF LTM | 6,434 |
FCF 3Y Avg | 5,191 |
CFO LTM | 6,857 |
CFO 3Y Avg | 5,636 |
Growth & Margins
Median | |
---|---|
Name | |
Rev Chg LTM | 8.3% |
Rev Chg 3Y Avg | 10.0% |
Rev Chg Q | 10.7% |
QoQ Delta Rev Chg LTM | 2.0% |
Op Mgn LTM | 17.5% |
Op Mgn 3Y Avg | 26.5% |
QoQ Delta Op Mgn LTM | 1.3% |
CFO/Rev LTM | 33.4% |
CFO/Rev 3Y Avg | 31.9% |
FCF/Rev LTM | 30.5% |
FCF/Rev 3Y Avg | 28.2% |
Valuation
Median | |
---|---|
Name | |
Mkt Cap | 119.6 |
P/S | 5.8 |
P/EBIT | 19.8 |
P/E | 24.8 |
P/CFO | 17.2 |
Total Yield | 3.8% |
Dividend Yield | 1.4% |
FCF Yield 3Y Avg | 4.1% |
D/E | 0.2 |
Net D/E | 0.0 |
Returns
Median | |
---|---|
Name | |
1M Rtn | -2.4% |
3M Rtn | 4.5% |
6M Rtn | -2.8% |
12M Rtn | 1.8% |
3Y Rtn | 52.6% |
1M Excs Rtn | -4.8% |
3M Excs Rtn | -4.9% |
6M Excs Rtn | -22.1% |
12M Excs Rtn | -15.7% |
3Y Excs Rtn | -7.7% |
Comparison Analyses
Returns Analyses
Earnings Returns History
Expand for MoreForward Returns | |||
---|---|---|---|
Earnings Date | 1D Returns | 5D Returns | 21D Returns |
8/7/2025 | -5.3% | 11.9% | 8.8% |
3/17/2025 | -16.2% | -13.9% | -26.9% |
11/12/2024 | -10.0% | -27.7% | -29.5% |
8/6/2024 | -13.5% | -1.5% | -24.1% |
3/13/2024 | -8.8% | -10.6% | -36.7% |
11/1/2023 | -22.1% | -35.7% | -23.1% |
8/8/2023 | -7.9% | -11.4% | -16.5% |
2/22/2023 | 0.3% | 1.4% | -41.6% |
... | |||
SUMMARY STATS | |||
# Positive | 8 | 9 | 6 |
# Negative | 12 | 11 | 14 |
Median Positive | 5.7% | 10.5% | 12.4% |
Median Negative | -9.4% | -10.6% | -16.0% |
Max Positive | 28.0% | 28.0% | 23.3% |
Max Negative | -22.1% | -35.7% | -41.6% |
SEC Filings
Expand for MoreReport Date | Filing Date | Filing |
---|---|---|
6302025 | 8072025 | 10-Q 6/30/2025 |
3312025 | 5122025 | 10-Q 3/31/2025 |
12312024 | 3172025 | 10-K 12/31/2024 |
9302024 | 11122024 | 10-Q 9/30/2024 |
6302024 | 8062024 | 10-Q 6/30/2024 |
3312024 | 5092024 | 10-Q 3/31/2024 |
12312023 | 3132024 | 10-K 12/31/2023 |
9302023 | 11012023 | 10-Q 9/30/2023 |
6302023 | 8082023 | 10-Q 6/30/2023 |
3312023 | 5082023 | 10-Q 3/31/2023 |
12312022 | 2232023 | 10-K 12/31/2022 |
9302022 | 11032022 | 10-Q 9/30/2022 |
6302022 | 8042022 | 10-Q 6/30/2022 |
3312022 | 5052022 | 10-Q 3/31/2022 |
12312021 | 2242022 | 10-K 12/31/2021 |
9302021 | 11042021 | 10-Q 9/30/2021 |
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