Tearsheet

Sangamo Therapeutics (SGMO)


Market Price (9/18/2025): $0.53 | Market Cap: $136.2 Mil
Sector: Health Care | Industry: Biotechnology

Sangamo Therapeutics (SGMO)


Market Price (9/18/2025): $0.53
Market Cap: $136.2 Mil
Sector: Health Care
Industry: Biotechnology

Investment Highlights

0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -11%
Weak multi-year price returns
2Y Excs Rtn is -99%, 3Y Excs Rtn is -152%
Penny stock
Mkt Price is 0.5
1 Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 566%
  Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -63 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -77%
2 Valuation becoming less expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is -54%
  Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -44%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -44%
3   Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -53%
4   High stock price volatility
Vol 12M is 133%
0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -11%
1 Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 566%
2 Valuation becoming less expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is -54%
3 Weak multi-year price returns
2Y Excs Rtn is -99%, 3Y Excs Rtn is -152%
4 Penny stock
Mkt Price is 0.5
5 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -63 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -77%
6 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -44%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -44%
7 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -53%
8 High stock price volatility
Vol 12M is 133%

Market Valuation

 9/18/252024202320222021
Share Price CYE$0.53$1.02$0.54$3.14$7.50
Market Cap CYE ($ Mil)136.2214.596.5517.61,093.1
Total Debt ($ Mil)23.530.638.143.148.1
Total Cash ($ Mil)38.341.981.0277.6376.5
Enterprise Value ($ Mil)121.3245.1134.6560.71,141.2
Valuation Ratios     
P/S TTM1.73.60.54.39.8
P/EBIT TTM-2.2-2.1-0.8-2.4-5.9
P/E TTM-2.1-2.1-0.4-2.5-6.1
Sector Ratios     
P/S TTM (Sector)3.83.64.14.57.3
P/EBIT TTM (Sector)-1.6-1.3-1.4-1.3-2.9
P/E TTM (Sector)-1.8-1.5-1.5-1.3-2.9
 9/18/2520242023
Share Price CYE$0.53$1.02$0.54
Market Cap CYE ($ Mil)136.2214.596.5
Total Debt ($ Mil)23.530.638.1
Total Cash ($ Mil)38.341.981.0
Enterprise Value ($ Mil)121.3245.1134.6
Valuation Ratios   
P/S TTM1.73.60.5
P/EBIT TTM-2.2-2.1-0.8
P/E TTM-2.1-2.1-0.4
Sector Ratios   
P/S TTM (Sector)3.83.64.1
P/EBIT TTM (Sector)-1.6-1.3-1.4
P/E TTM (Sector)-1.8-1.5-1.5

Business Description

Sangamo Therapeutics, Inc., a clinical-stage biotechnology company, focuses on translating science into genomic medicines that transform patients' lives using platform technologies in gene therapy, cell therapy, genome editing, and genome regulation. The company offers zinc finger protein (ZFP), a technology platform for making zinc finger nucleases, which are proteins used in modifying DNA sequences by adding or knocking out specific genes; and ZFP transcription factors proteins used in increasing or decreasing gene expression. It develops SB-525, which is in Phase III AFFINE clinical trial for the treatment of hemophilia A; ST-920, a gene therapy, which is in Phase I/II STAAR clinical trials for the treatment of Fabry disease; and SAR445136, a cell therapy, which is in Phase I/II PRECIZN-1 clinical trials for the treatment of sickle cell disease. Show more

Price Returns Compared

Expand for Detailed View

 202020212022202320242025Total [1]
Returns
SGMO Return86%-52%-58%-83%88%-50%-94%
Peers Return43%25%6%32%20%22%267%
S&P 500 Return16%27%-19%24%23%12%104%

[1] Cumulative total returns since the beginning of 2020
[2] Peers: PTGX, ABBV, AMGN, GILD, VRTX. See SGMO Returns vs. Peers.
[3] 2025 data is for the year up to 9/17/2025 (YTD)

Better Bets than Sangamo Therapeutics (SGMO)

Latest Trefis Analyses

Recent Active Movers

Recent Active Movers

More From Trefis

Peer Comparisons for Sangamo Therapeutics

Financials

SGMOPTGXABBVAMGNGILDVRTXMedian
NameSangamo .Protagon.AbbVie Amgen Gilead S.Vertex P. 
Mkt Price0.5159.22220.81274.71112.26387.15166.53
Mkt Cap0.13.8390.4147.8139.899.4119.6
Rev LTM8220958,32834,91728,86211,41920,140
Op Inc LTM-632413,6958,19210,797-1994,108
FCF LTM-363718,23910,6059,3693,5006,434
FCF 3Y Avg-1605020,2738,5908,3971,9845,191
CFO LTM-364019,28312,0139,8683,8466,857
CFO 3Y Avg-1495121,1549,7538,9492,3245,636

Growth & Margins

SGMOPTGXABBVAMGNGILDVRTXMedian
NameSangamo .Protagon.AbbVie Amgen Gilead S.Vertex P. 
Rev Chg LTM565.5%-34.5%6.1%12.9%3.8%10.5%8.3%
Rev Chg 3Y Avg187.5%-0.6%10.0%1.6%11.0%10.0%
Rev Chg Q5,042.1%33.1%6.6%9.4%1.8%12.1%10.7%
QoQ Delta Rev Chg LTM28.2%0.7%1.7%2.3%0.4%2.9%2.0%
Op Mgn LTM-76.9%11.5%23.5%23.5%37.4%-1.7%17.5%
Op Mgn 3Y Avg-602.4%-27.2%26.4%39.2%26.5%26.5%
QoQ Delta Op Mgn LTM50.0%-1.6%1.0%1.6%-0.0%2.0%1.3%
CFO/Rev LTM-43.9%18.9%33.1%34.4%34.2%33.7%33.4%
CFO/Rev 3Y Avg-521.6%-37.5%32.0%31.9%22.5%31.9%
FCF/Rev LTM-44.1%17.7%31.3%30.4%32.5%30.6%30.5%
FCF/Rev 3Y Avg-540.6%-36.0%28.2%30.0%19.2%28.2%

Valuation

SGMOPTGXABBVAMGNGILDVRTXMedian
NameSangamo .Protagon.AbbVie Amgen Gilead S.Vertex P. 
Mkt Cap0.13.8390.4147.8139.899.4119.6
P/S1.618.06.74.24.88.75.8
P/EBIT-2.1156.966.314.317.022.619.8
P/E-2.172.3103.722.322.127.324.8
P/CFO-3.795.120.212.314.225.817.2
Total Yield-48.3%1.4%3.9%7.8%7.3%3.7%3.8%
Dividend Yield0.0%0.0%2.9%3.4%2.8%0.0%1.4%
FCF Yield 3Y Avg-129.2%1.5%7.3%6.2%8.0%2.1%4.1%
D/E0.20.00.20.40.20.00.2
Net D/E-0.1-0.10.20.30.1-0.00.0

Returns

SGMOPTGXABBVAMGNGILDVRTXMedian
NameSangamo .Protagon.AbbVie Amgen Gilead S.Vertex P. 
1M Rtn-13.0%5.4%6.9%-6.1%-4.2%-0.7%-2.4%
3M Rtn4.4%9.8%20.1%-4.4%4.7%-13.7%4.5%
6M Rtn-41.0%9.0%5.9%-11.5%5.9%-24.5%-2.8%
12M Rtn-38.5%31.9%18.2%-14.7%39.2%-19.6%1.8%
3Y Rtn-90.2%608.4%71.6%30.8%90.5%33.6%52.6%
1M Excs Rtn-15.3%3.0%4.5%-8.5%-6.5%-3.0%-4.8%
3M Excs Rtn-4.2%-3.1%9.8%-14.8%-5.7%-22.7%-4.9%
6M Excs Rtn-57.0%-8.9%-12.4%-29.9%-14.3%-42.0%-22.1%
12M Excs Rtn-56.9%8.6%0.4%-31.9%22.3%-37.6%-15.7%
3Y Excs Rtn-151.7%497.4%13.2%-33.4%25.2%-28.7%-7.7%

Financials

Segment Financials

Revenue by Segment

$ Mil20242023202220212020
Single Segment176111111118102
Total176111111118102


Net Income by Segment
$ Mil20242023202220212020
Single Segment-258    
Total-258    


Price Behavior

Short Interest

Short Interest: As Of Date8292025
Short Interest: Shares Quantity14,978,395
Short Interest: % Change Since 8152025-6.1%
Average Daily Volume4,264,819
Days-to-Cover Short Interest3.51
Basic Shares Quantity256,950,000
Short % of Basic Shares5.8%

Earnings Returns History

Expand for More

 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
8/7/2025-5.3%11.9%8.8%
3/17/2025-16.2%-13.9%-26.9%
11/12/2024-10.0%-27.7%-29.5%
8/6/2024-13.5%-1.5%-24.1%
3/13/2024-8.8%-10.6%-36.7%
11/1/2023-22.1%-35.7%-23.1%
8/8/2023-7.9%-11.4%-16.5%
2/22/20230.3%1.4%-41.6%
...
SUMMARY STATS   
# Positive896
# Negative121114
Median Positive5.7%10.5%12.4%
Median Negative-9.4%-10.6%-16.0%
Max Positive28.0%28.0%23.3%
Max Negative-22.1%-35.7%-41.6%

SEC Filings

Expand for More

Report DateFiling DateFiling
6302025807202510-Q 6/30/2025
3312025512202510-Q 3/31/2025
12312024317202510-K 12/31/2024
93020241112202410-Q 9/30/2024
6302024806202410-Q 6/30/2024
3312024509202410-Q 3/31/2024
12312023313202410-K 12/31/2023
93020231101202310-Q 9/30/2023
6302023808202310-Q 6/30/2023
3312023508202310-Q 3/31/2023
12312022223202310-K 12/31/2022
93020221103202210-Q 9/30/2022
6302022804202210-Q 6/30/2022
3312022505202210-Q 3/31/2022
12312021224202210-K 12/31/2021
93020211104202110-Q 9/30/2021

Insider Activity

Expand for More