Tearsheet

Regeneron Pharmaceuticals (REGN)


Market Price (10/24/2025): $576.88 | Market Cap: $60.6 Bil
Sector: Health Care | Industry: Biotechnology

Regeneron Pharmaceuticals (REGN)


Market Price (10/24/2025): $576.88
Market Cap: $60.6 Bil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Which of these 2 stories sounds closer for this stock?

1. Generates cash flow

The stock generated 4% or more of the share price (called cash flow yield), and shows moderate 10-15% or more growth.

2. Riding a trend

Think Tesla during the pandemic of 2020 when EVs were riding a cultural high, or Nvidia in the current AI boom, or even Figma. These companies don’t have enough yield, or, enough growth, or both - however - they are riding a trend. They have momentum. These can be more volatile - they don’t have the floor of strong cash flow


0 Attractive yield
Total YieldTotal Yield = Earnings Yield + Dividend Yield, Earnings Yield = Net Income / Market Cap Dividend Yield = Total Dividends / Market Cap is 7.7%, ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is 3.1%, FCF Yield is 5.9%
Weak multi-year price returns
2Y Excs Rtn is -86%, 3Y Excs Rtn is -101%
Weak revenue growth
Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is 0.3%
1 Attractive operating margins
Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is 27%
  
2 Attractive cash flow generation
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is 33%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is 25%, CFO LTM is 4.7 Bil, FCF LTM is 3.6 Bil
  
3 Valuation becoming less expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is -28%
  
4 Low stock price volatility
Vol 12M is 40%
  
0 Attractive yield
Total YieldTotal Yield = Earnings Yield + Dividend Yield, Earnings Yield = Net Income / Market Cap Dividend Yield = Total Dividends / Market Cap is 7.7%, ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is 3.1%, FCF Yield is 5.9%
1 Attractive operating margins
Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is 27%
2 Attractive cash flow generation
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is 33%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is 25%, CFO LTM is 4.7 Bil, FCF LTM is 3.6 Bil
3 Valuation becoming less expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is -28%
4 Low stock price volatility
Vol 12M is 40%
5 Weak multi-year price returns
2Y Excs Rtn is -86%, 3Y Excs Rtn is -101%
6 Weak revenue growth
Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is 0.3%

Market Valuation & Key Metrics

REGN Stock


Return vs. Risk


Price Returns Compared

 202020212022202320242025Total [1]
Returns
REGN Return29%31%14%22%-19%-19%55%
Peers Return-2%2%20%-5%-12%8%8%
S&P 500 Return16%27%-19%24%23%15%106%

Monthly Win Rates [3]
REGN Win Rate50%67%50%58%50%44% 
Peers Win Rate50%47%53%42%45%49% 
S&P 500 Win Rate58%75%42%67%75%67% 

Max Drawdowns [4]
REGN Max Drawdown-10%-8%-13%-6%-20%-32% 
Peers Max Drawdown-22%-13%-13%-21%-25%-14% 
S&P 500 Max Drawdown-31%-1%-25%-1%-2%-15% 


[1] Cumulative total returns since the beginning of 2020
[2] Peers: AMGN, GILD, BIIB, BMRN, JAZZ. See REGN Returns vs. Peers.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2025 data is for the year up to 10/23/2025 (YTD)

How Low Can It Go

Unique KeyEventREGNS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-25.8%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven34.7%34.1%
2022 Inflation ShockTime to BreakevenTime to Breakeven112 days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-27.3%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven37.6%51.3%
2020 Covid PandemicTime to BreakevenTime to Breakeven233 days148 days
2018 Correction2018 Correction  
2018 Correction% Loss% Loss-48.1%-19.8%
2018 Correction% Gain to Breakeven% Gain to Breakeven92.5%24.7%
2018 CorrectionTime to BreakevenTime to Breakeven202 days120 days
2008 Global Financial Crisis2008 Global Financial Crisis  
2008 Global Financial Crisis% Loss% Loss-57.9%-56.8%
2008 Global Financial Crisis% Gain to Breakeven% Gain to Breakeven137.3%131.3%
2008 Global Financial CrisisTime to BreakevenTime to Breakeven329 days1480 days

Compare to AMGN, GILD, BIIB, BMRN, JAZZ


In The Past

Regeneron Pharmaceuticals's stock fell -25.8% during the 2022 Inflation Shock from a high on 4/8/2022. A -25.8% loss requires a 34.7% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth over time.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About Regeneron Pharmaceuticals (REGN)

Better Bets than Regeneron Pharmaceuticals (REGN)

Latest Trefis Analyses

Trade Ideas

Select past ideas related to REGN. For more, see Trefis Trade Ideas.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
ADMA_9302025_Dip_Buyer_ValueBuy09302025ADMAADMA BiologicsDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
3.4%3.4%-4.6%
REGN_9302025_Dip_Buyer_ValueBuy09302025REGNRegeneron PharmaceuticalsDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
4.0%4.0%-0.8%
HAE_9262025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG09262025HAEHaemoneticsDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
6.6%6.6%-0.1%
WAT_9192025_Monopoly_xInd_xCD_Getting_Cheaper09192025WATWatersMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
15.9%15.9%-4.3%
ISRG_9052025_Monopoly_xInd_xCD_Getting_Cheaper09052025ISRGIntuitive SurgicalMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
12.9%12.9%-8.0%
REGN_3312025_Dip_Buyer_FCFYield03312025REGNRegeneron PharmaceuticalsDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
-11.3%-7.5%-23.7%
REGN_5312019_Dip_Buyer_FCFYield05312019REGNRegeneron PharmaceuticalsDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
22.3%103.1%-9.4%
Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
ADMA_9302025_Dip_Buyer_ValueBuy09302025ADMAADMA BiologicsDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
3.4%3.4%-4.6%
REGN_9302025_Dip_Buyer_ValueBuy09302025REGNRegeneron PharmaceuticalsDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
4.0%4.0%-0.8%
HAE_9262025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG09262025HAEHaemoneticsDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
6.6%6.6%-0.1%
WAT_9192025_Monopoly_xInd_xCD_Getting_Cheaper09192025WATWatersMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
15.9%15.9%-4.3%
ISRG_9052025_Monopoly_xInd_xCD_Getting_Cheaper09052025ISRGIntuitive SurgicalMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
12.9%12.9%-8.0%
REGN_3312025_Dip_Buyer_FCFYield03312025REGNRegeneron PharmaceuticalsDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
-11.3%-7.5%-23.7%
REGN_5312019_Dip_Buyer_FCFYield05312019REGNRegeneron PharmaceuticalsDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
22.3%103.1%-9.4%

Recent Active Movers

Recent Active Movers

More From Trefis

Peer Comparisons for Regeneron Pharmaceuticals

Financials

REGNAMGNGILDBIIBBMRNJAZZMedian
NameRegenero.Amgen Gilead S.Biogen BioMarin.Jazz Pha. 
Mkt Price575.69292.89120.74150.0854.55138.18144.13
Mkt Cap60.5157.6150.321.910.58.541.2
Rev LTM14,21434,91728,8629,8163,0644,08712,015
Op Inc LTM3,8418,19210,7972,2747766143,058
FCF LTM3,55610,6059,3692,2966911,2402,926
FCF 3Y Avg3,2488,5908,3971,6673151,0802,458
CFO LTM4,74412,0139,8682,5827671,3163,663
CFO 3Y Avg4,5189,7538,9491,9684191,2563,243

Growth & Margins

REGNAMGNGILDBIIBBMRNJAZZMedian
NameRegenero.Amgen Gilead S.Biogen BioMarin.Jazz Pha. 
Rev Chg LTM5.4%12.9%3.8%1.6%18.4%4.5%4.9%
Rev Chg 3Y Avg0.3%10.0%1.6%-3.1%17.0%5.5%3.6%
Rev Chg Q3.6%9.4%1.8%6.1%15.9%2.1%4.9%
QoQ Delta Rev Chg LTM0.9%2.3%0.4%1.5%3.8%0.5%1.2%
Op Mgn LTM27.0%23.5%37.4%23.2%25.3%15.0%24.4%
Op Mgn 3Y Avg30.1%26.4%39.2%23.4%14.0%14.9%24.9%
QoQ Delta Op Mgn LTM-0.2%1.6%-0.0%0.2%4.3%0.4%0.3%
CFO/Rev LTM33.4%34.4%34.2%26.3%25.0%32.2%32.8%
CFO/Rev 3Y Avg33.6%32.0%31.9%20.0%15.0%32.1%31.9%
FCF/Rev LTM25.0%30.4%32.5%23.4%22.6%30.3%27.7%
FCF/Rev 3Y Avg24.1%28.2%30.0%16.9%10.9%27.5%25.8%

Valuation

REGNAMGNGILDBIIBBMRNJAZZMedian
NameRegenero.Amgen Gilead S.Biogen BioMarin.Jazz Pha. 
Mkt Cap60.5157.6150.321.910.58.541.2
P/S4.34.55.22.23.42.13.8
P/EBIT12.315.218.311.012.3-28.212.3
P/E13.623.823.814.815.9-20.915.4
P/CFO12.813.115.28.513.76.412.9
Total Yield7.7%7.4%6.8%6.7%6.3%-4.8%6.8%
Dividend Yield0.3%3.2%2.6%0.0%0.0%0.0%0.2%
FCF Yield 3Y Avg4.4%6.2%8.0%6.6%2.7%15.5%6.4%
D/E0.00.40.20.30.10.60.2
Net D/E-0.10.30.10.2-0.10.40.2

Returns

REGNAMGNGILDBIIBBMRNJAZZMedian
NameRegenero.Amgen Gilead S.Biogen BioMarin.Jazz Pha. 
1M Rtn1.4%2.1%5.5%7.7%2.1%6.8%3.8%
3M Rtn2.1%-4.3%7.4%13.2%-8.7%17.1%4.8%
6M Rtn-3.7%6.4%15.3%25.6%-13.1%26.8%10.9%
12M Rtn-38.6%-3.9%42.5%-18.0%-22.0%24.3%-10.9%
3Y Rtn-21.6%23.3%94.8%-45.3%-39.3%2.5%-9.5%
1M Excs Rtn-1.7%3.4%4.7%7.5%-0.1%5.1%4.0%
3M Excs Rtn-3.1%-9.2%-0.8%8.6%-13.0%11.4%-2.0%
6M Excs Rtn-26.6%-16.4%-7.5%2.7%-35.9%3.9%-12.0%
12M Excs Rtn-55.4%-19.5%29.0%-33.8%-37.5%7.0%-26.7%
3Y Excs Rtn-101.1%-53.3%19.8%-125.6%-120.2%-78.8%-90.0%

Financials

Segment Financials

Revenue by Segment

$ Mil20242023202220212020
EYLEA ®5,7206,2655,7924,9474,644
Collaboration revenue5,5034,9143,673  
Libtayo ®539374306271176
Other revenue536365281557174
Libtayo324730  
Praluent ®182130170151 
EYLEA HD ®16600  
Evkeeza ®774918  
Inmazeb ®7030  
ARCALYST ®  21314
REGEN-COV ®  5,828186 
Bayer   1,1861,146
Sanofi   1,186404
Total13,11712,17316,0728,4976,558


Price Behavior

Short Interest

Short Interest: As Of Date9302025
Short Interest: Shares Quantity2,760,203
Short Interest: % Change Since 9152025-7.5%
Average Daily Volume1,168,677
Days-to-Cover Short Interest2.36
Basic Shares Quantity105,100,000
Short % of Basic Shares2.6%

Earnings Returns History

Expand for More

 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
8/1/20252.5%2.6%6.6%
4/29/2025-6.9%-1.2%-3.0%
1/13/20252.9%-2.2%-4.5%
10/31/2024-9.2%-11.5%-18.7%
8/1/20241.3%-1.1%9.2%
5/2/20243.8%5.8%8.5%
2/2/2024-1.3%-1.2%1.4%
11/2/20233.5%4.0%3.0%
...
SUMMARY STATS   
# Positive181114
# Negative71411
Median Positive3.4%5.8%7.6%
Median Negative-3.7%-1.9%-4.5%
Max Positive6.9%10.7%32.9%
Max Negative-9.2%-11.5%-18.7%

SEC Filings

Expand for More

Report DateFiling DateFiling
6302025801202510-Q 6/30/2025
3312025429202510-Q 3/31/2025
12312024205202510-K 12/31/2024
93020241031202410-Q 9/30/2024
6302024801202410-Q 6/30/2024
3312024502202410-Q 3/31/2024
12312023205202410-K 12/31/2023
93020231102202310-Q 9/30/2023
6302023803202310-Q 6/30/2023
3312023504202310-Q 3/31/2023
12312022206202310-K 12/31/2022
93020221103202210-Q 9/30/2022
6302022803202210-Q 6/30/2022
3312022504202210-Q 3/31/2022
12312021207202210-K 12/31/2021
93020211104202110-Q 9/30/2021

Insider Activity

Expand for More

 OwnerTitleFiling DateActionPriceSharesTransacted
Value
Value of
Held Shares
Form
0RYAN ARTHUR F 10032024Sell1041.3533,12418,410,027Form