Tearsheet

Illumina (ILMN)


Market Price (9/13/2025): $95.36 | Market Cap: $15.0 Bil
Sector: Health Care | Industry: Life Sciences Tools & Services

Illumina (ILMN)


Market Price (9/13/2025): $95.36
Market Cap: $15.0 Bil
Sector: Health Care
Industry: Life Sciences Tools & Services

Investment Highlights

0 Attractive yield
Total YieldTotal Yield = Earnings Yield + Dividend Yield, Earnings Yield = Net Income / Market Cap Dividend Yield = Total Dividends / Market Cap is 8.4%, ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is 3.9%, FCF Yield is 6.9%
Weak multi-year price returns
2Y Excs Rtn is -86%, 3Y Excs Rtn is -118%
Weak revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is -3.3%, Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -3.0%, Rev Chg QQuarterly Revenue Change % is -4.8%
1 Attractive operating margins
Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is 19%
  
2 Attractive cash flow generation
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is 27%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is 24%
  
3 Valuation becoming less expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is -28%
  
4 Low stock price volatility
Vol 12M is 42%
  
0 Attractive yield
Total YieldTotal Yield = Earnings Yield + Dividend Yield, Earnings Yield = Net Income / Market Cap Dividend Yield = Total Dividends / Market Cap is 8.4%, ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is 3.9%, FCF Yield is 6.9%
1 Attractive operating margins
Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is 19%
2 Attractive cash flow generation
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is 27%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is 24%
3 Valuation becoming less expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is -28%
4 Low stock price volatility
Vol 12M is 42%
5 Weak multi-year price returns
2Y Excs Rtn is -86%, 3Y Excs Rtn is -118%
6 Weak revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is -3.3%, Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -3.0%, Rev Chg QQuarterly Revenue Change % is -4.8%

Market Valuation

 9/13/252024202320222021
Share Price CYE$95.36$133.63$135.32$196.50$369.72
Market Cap CYE ($ Bil)15.021.221.430.956.2
Total Debt ($ Bil)2.62.62.33.62.5
Total Cash ($ Bil)1.21.21.12.01.3
Enterprise Value ($ Bil)16.423.823.734.558.7
Valuation Ratios     
P/S TTM3.54.94.86.712.2
P/EBIT TTM9.9-19.7-20.6-7.258.7
P/E TTM11.9-17.4-18.4-7.072.8
Sector Ratios     
P/S TTM (Sector)3.83.64.14.57.3
P/EBIT TTM (Sector)-1.6-1.3-1.4-1.3-2.9
P/E TTM (Sector)-1.9-1.6-1.5-1.4-2.9
 9/13/2520242023
Share Price CYE$95.36$133.63$135.32
Market Cap CYE ($ Bil)15.021.221.4
Total Debt ($ Bil)2.62.62.3
Total Cash ($ Bil)1.21.21.1
Enterprise Value ($ Bil)16.423.823.7
Valuation Ratios   
P/S TTM3.54.94.8
P/EBIT TTM9.9-19.7-20.6
P/E TTM11.9-17.4-18.4
Sector Ratios   
P/S TTM (Sector)3.83.64.1
P/EBIT TTM (Sector)-1.6-1.3-1.4
P/E TTM (Sector)-1.9-1.6-1.5

Business Description

Illumina, Inc. provides sequencing and array-based solutions for genetic and genomic analysis. Its products and services serve customers in a range of markets enabling the adoption of genomic solutions in research and clinical settings for applications in the life sciences, oncology, reproductive health, agriculture, and other emerging segments. Show more

Price Returns Compared

Expand for Detailed View

 202020212022202320242025Total [1]
Returns
ILMN Return12%3%-47%-31%-1%-26%-69%
Peers Return44%38%-27%10%-20%-16%7%
S&P 500 Return16%27%-19%24%23%12%101%

[1] Cumulative total returns since the beginning of 2020
[2] Peers: TMO, A, BRKR, TXG, DHR. See ILMN Returns vs. Peers.
[3] 2025 data is for the year up to 9/12/2025 (YTD)

Latest Trefis Analyses

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Peer Comparisons for Illumina

Financials

ILMNTMOABRKRTXGDHRMedian
NameIllumina Thermo F.Agilent .Bruker 10x Geno.Danaher  
Mkt Price95.12479.46123.2430.9112.64190.05109.18
Mkt Cap14.9181.235.04.71.6136.225.0
Rev LTM4,28443,2116,7883,44364424,0135,536
Op Inc LTM8247,8601,444329-1504,4171,134
FCF LTM1,0246,1701,08849574,8621,056
FCF 3Y Avg3866,6621,308139-325,733847
CFO LTM1,1547,5781,495166676,1691,324
CFO 3Y Avg6288,2061,662260167,0131,145

Growth & Margins

ILMNTMOABRKRTXGDHRMedian
NameIllumina Thermo F.Agilent .Bruker 10x Geno.Danaher  
Rev Chg LTM-3.3%2.0%4.5%10.4%2.0%1.9%2.0%
Rev Chg 3Y Avg-3.0%0.3%0.8%11.6%9.1%-2.6%0.6%
Rev Chg Q-4.8%3.0%10.1%-0.4%12.9%3.4%3.2%
QoQ Delta Rev Chg LTM-1.2%0.7%2.4%-0.1%3.2%0.8%0.8%
Op Mgn LTM19.2%18.2%21.3%9.5%-23.3%18.4%18.3%
Op Mgn 3Y Avg6.7%17.4%21.5%13.7%-28.4%21.6%15.5%
QoQ Delta Op Mgn LTM-0.6%-0.1%-0.1%-1.3%5.7%-1.9%-0.3%
CFO/Rev LTM26.9%17.5%22.0%4.8%10.4%25.7%19.8%
CFO/Rev 3Y Avg14.5%19.1%24.6%8.7%2.4%29.9%16.8%
FCF/Rev LTM23.9%14.3%16.0%1.4%8.8%20.2%15.2%
FCF/Rev 3Y Avg9.0%15.5%19.4%4.7%-5.8%24.4%12.2%

Valuation

ILMNTMOABRKRTXGDHRMedian
NameIllumina Thermo F.Agilent .Bruker 10x Geno.Danaher  
Mkt Cap14.9181.235.04.71.6136.225.0
P/S3.54.25.21.42.45.73.8
P/EBIT9.921.623.224.3-19.731.222.4
P/E11.927.528.758.9-18.539.928.1
P/CFO12.923.923.428.223.422.123.4
Total Yield8.4%3.6%4.3%2.3%-5.4%2.5%3.1%
Dividend Yield0.0%0.0%0.8%0.7%0.0%0.0%0.0%
FCF Yield 3Y Avg2.7%3.6%3.7%1.5%0.2%3.4%3.1%
D/E0.20.20.10.50.10.10.2
Net D/E0.10.20.10.5-0.20.10.1

Returns

ILMNTMOABRKRTXGDHRMedian
NameIllumina Thermo F.Agilent .Bruker 10x Geno.Danaher  
1M Rtn-5.9%-1.1%2.5%-10.5%-6.9%-9.1%-6.4%
3M Rtn9.4%19.0%5.5%-19.3%21.4%-5.1%7.5%
6M Rtn11.1%-8.1%2.1%-32.6%22.2%-9.5%-3.0%
12M Rtn-24.7%-21.7%-8.9%-52.1%-43.9%-29.9%-27.3%
3Y Rtn-50.8%-13.6%-5.7%-43.7%-61.7%-23.0%-33.3%
1M Excs Rtn-7.7%-2.9%0.6%-12.3%-8.7%-10.9%-8.2%
3M Excs Rtn-1.0%6.5%-5.1%-31.4%10.6%-16.1%-3.0%
6M Excs Rtn-6.1%-24.9%-13.8%-50.3%8.7%-25.8%-19.3%
12M Excs Rtn-43.2%-42.8%-29.8%-70.8%-61.5%-50.3%-46.7%
3Y Excs Rtn-117.9%-77.8%-69.6%-110.0%-126.4%-87.3%-98.6%

Financials

Segment Financials

Revenue by Segment

$ Mil20242023202220212020
Core Illumina4,4384,5534,5193,2393,543
GRAIL935512  
Eliminations-26-24-5 -1
Helix    1
Total4,5054,5844,5263,2393,543


Operating Income by Segment
$ Mil20242023202220212020
Core Illumina5524818085801,008
Eliminations  0 -24
GRAIL  -931  
Helix    1
Total552481-123580985


Assets by Segment
$ Mil20242023202220212020
Core Illumina   7,5857,316
Total   7,5857,316


Price Behavior

Short Interest

Short Interest: As Of Date8292025
Short Interest: Shares Quantity7,215,892
Short Interest: % Change Since 8152025-4.0%
Average Daily Volume1,356,672
Days-to-Cover Short Interest5.32
Basic Shares Quantity157,000,000
Short % of Basic Shares4.6%

Earnings Returns History

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 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
7/31/2025-7.8%-7.0%-2.7%
5/8/2025-4.8%1.7%6.8%
1/14/2025-5.4%-2.0%-28.2%
11/4/20241.0%-1.3%-7.2%
8/6/20244.1%2.9%11.5%
5/2/2024-4.9%-10.2%-16.6%
2/8/2024-3.8%1.9%-3.0%
11/9/2023-8.0%-11.0%10.0%
...
SUMMARY STATS   
# Positive678
# Negative181716
Median Positive2.5%3.8%7.7%
Median Negative-6.2%-8.1%-8.7%
Max Positive7.9%13.3%24.9%
Max Negative-14.6%-25.5%-28.2%

Insider Activity

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 OwnerTitleFiling DateActionPriceSharesTransacted
Value
Value of
Held Shares
Form
0Dhingra AnkurSVP, Chief Financial Officer5142025Buy81.216,100495,3812,022,616Form
1Thaysen JacobChief Executive Officer5142025Buy79.701,20095,6405,757,528Form