CRISPR Therapeutics (CRSP)
Market Price (9/18/2025): $59.49 | Market Cap: $5.2 BilSector: Health Care | Industry: Biotechnology
CRISPR Therapeutics (CRSP)
Market Price (9/18/2025): $59.49Market Cap: $5.2 BilSector: Health CareIndustry: Biotechnology
Investment Highlights
Cash is significant % of market capNet D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -29% | Weak multi-year price returns2Y Excs Rtn is -28%, 3Y Excs Rtn is -76% | Not profitable at operating income levelOp Inc LTMOperating Income, Last Twelve Months is -552 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -1578% |
Meaningful short interestShort Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 13 | Expensive valuation multiplesP/SPrice/Sales ratio is 147x | |
Weak revenue growthRev Chg LTMRevenue Change % Last Twelve Months (LTM) is -82% | ||
Not cash flow generativeCFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -928%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -1002% | ||
Yield minus risk free rate is negativeERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -14% | ||
Significant short interestShort Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 25% |
Cash is significant % of market capNet D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -29% |
Weak multi-year price returns2Y Excs Rtn is -28%, 3Y Excs Rtn is -76% |
Meaningful short interestShort Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 13 |
Not profitable at operating income levelOp Inc LTMOperating Income, Last Twelve Months is -552 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -1578% |
Expensive valuation multiplesP/SPrice/Sales ratio is 147x |
Weak revenue growthRev Chg LTMRevenue Change % Last Twelve Months (LTM) is -82% |
Not cash flow generativeCFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -928%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -1002% |
Yield minus risk free rate is negativeERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -14% |
Significant short interestShort Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 25% |
Market Valuation
9/18/25 | 2024 | 2023 | 2022 | 2021 | |
---|---|---|---|---|---|
Share Price CYE | $59.49 | $39.36 | $62.60 | $40.65 | $75.78 |
Market Cap CYE ($ Bil) | 5.2 | 3.4 | 5.0 | 3.2 | 5.8 |
Total Debt ($ Bil) | 0.2 | 0.2 | 0.2 | 0.2 | 0.2 |
Total Cash ($ Bil) | 1.7 | 1.9 | 1.7 | 1.8 | 2.4 |
Enterprise Value ($ Bil) | 3.7 | 3.6 | 5.2 | 3.4 | 6.0 |
Valuation Ratios | |||||
P/S TTM | 148.0 | 94.9 | 13.4 | 7248.6 | 6.3 |
P/EBIT TTM | -9.4 | -7.1 | -22.3 | -4.7 | 15.4 |
P/E TTM | -11.1 | -9.1 | -32.3 | -4.9 | 15.2 |
Sector Ratios | |||||
P/S TTM (Sector) | 3.8 | 3.6 | 4.1 | 4.5 | 7.3 |
P/EBIT TTM (Sector) | -1.6 | -1.3 | -1.4 | -1.3 | -2.9 |
P/E TTM (Sector) | -1.8 | -1.5 | -1.5 | -1.3 | -2.9 |
9/18/25 | 2024 | 2023 | |
---|---|---|---|
Share Price CYE | $59.49 | $39.36 | $62.60 |
Market Cap CYE ($ Bil) | 5.2 | 3.4 | 5.0 |
Total Debt ($ Bil) | 0.2 | 0.2 | 0.2 |
Total Cash ($ Bil) | 1.7 | 1.9 | 1.7 |
Enterprise Value ($ Bil) | 3.7 | 3.6 | 5.2 |
Valuation Ratios | |||
P/S TTM | 148.0 | 94.9 | 13.4 |
P/EBIT TTM | -9.4 | -7.1 | -22.3 |
P/E TTM | -11.1 | -9.1 | -32.3 |
Sector Ratios | |||
P/S TTM (Sector) | 3.8 | 3.6 | 4.1 |
P/EBIT TTM (Sector) | -1.6 | -1.3 | -1.4 |
P/E TTM (Sector) | -1.8 | -1.5 | -1.5 |
Business Description
CRISPR Therapeutics AG, a gene editing company, focuses on developing gene-based medicines for serious diseases using its proprietary Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) platform. Its CRISPR/Cas9 is a gene editing technology that allows for precise directed changes to genomic DNA. The company has a portfolio of therapeutic programs across a range of disease areas, including hemoglobinopathies, oncology, regenerative medicine, and rare diseases.
Show more
Price Returns Compared
Expand for Detailed View2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total [1] | |
---|---|---|---|---|---|---|---|
Returns | |||||||
CRSP Return | 151% | -51% | -46% | 54% | -37% | 50% | -8% |
Peers Return | 60% | 35% | 6% | 8% | -6% | 13% | 159% |
S&P 500 Return | 16% | 27% | -19% | 24% | 23% | 12% | 104% |
[1] Cumulative total returns since the beginning of 2020
[2] Peers: NTLA, ABBV, AMGN, GILD, VRTX. See CRSP Returns vs. Peers.
[3] 2025 data is for the year up to 9/17/2025 (YTD)
Latest Trefis Analyses
Research & Analysis
Invest in Strategies
Wealth Management
Peer Comparisons for CRISPR Therapeutics
Financials
Median | |
---|---|
Name | |
Mkt Price | 166.53 |
Mkt Cap | 119.6 |
Rev LTM | 20,140 |
Op Inc LTM | 3,996 |
FCF LTM | 6,434 |
FCF 3Y Avg | 5,191 |
CFO LTM | 6,857 |
CFO 3Y Avg | 5,636 |
Growth & Margins
Median | |
---|---|
Name | |
Rev Chg LTM | 8.3% |
Rev Chg 3Y Avg | 8.1% |
Rev Chg Q | 9.4% |
QoQ Delta Rev Chg LTM | 2.0% |
Op Mgn LTM | 10.9% |
Op Mgn 3Y Avg | 26.5% |
QoQ Delta Op Mgn LTM | 1.3% |
CFO/Rev LTM | 33.4% |
CFO/Rev 3Y Avg | 27.2% |
FCF/Rev LTM | 30.5% |
FCF/Rev 3Y Avg | 23.7% |
Valuation
Median | |
---|---|
Name | |
Mkt Cap | 119.6 |
P/S | 7.7 |
P/EBIT | 15.7 |
P/E | 22.2 |
P/CFO | 13.2 |
Total Yield | 3.8% |
Dividend Yield | 1.4% |
FCF Yield 3Y Avg | 4.1% |
D/E | 0.1 |
Net D/E | 0.0 |
Returns
Median | |
---|---|
Name | |
1M Rtn | 0.9% |
3M Rtn | 12.4% |
6M Rtn | 5.9% |
12M Rtn | 1.8% |
3Y Rtn | 32.2% |
1M Excs Rtn | -1.4% |
3M Excs Rtn | 2.0% |
6M Excs Rtn | -13.4% |
12M Excs Rtn | -15.7% |
3Y Excs Rtn | -31.0% |
Comparison Analyses
Returns Analyses
Earnings Returns History
Expand for MoreForward Returns | |||
---|---|---|---|
Earnings Date | 1D Returns | 5D Returns | 21D Returns |
8/4/2025 | -6.7% | -7.0% | -11.1% |
5/6/2025 | 3.3% | 12.2% | 16.3% |
2/11/2025 | 9.3% | 33.8% | 6.0% |
11/5/2024 | -0.5% | 8.4% | 1.1% |
8/5/2024 | -0.7% | -5.5% | -9.3% |
5/8/2024 | 0.5% | 6.9% | 8.6% |
2/21/2024 | 4.7% | 13.2% | -7.4% |
11/6/2023 | 13.6% | 0.8% | 37.9% |
... | |||
SUMMARY STATS | |||
# Positive | 15 | 13 | 14 |
# Negative | 9 | 11 | 10 |
Median Positive | 5.1% | 12.2% | 11.4% |
Median Negative | -3.4% | -7.0% | -11.0% |
Max Positive | 13.6% | 33.8% | 70.8% |
Max Negative | -6.7% | -13.0% | -34.8% |
SEC Filings
Expand for MoreReport Date | Filing Date | Filing |
---|---|---|
6302025 | 8042025 | 10-Q 6/30/2025 |
3312025 | 5062025 | 10-Q 3/31/2025 |
12312024 | 2112025 | 10-K 12/31/2024 |
9302024 | 11052024 | 10-Q 9/30/2024 |
6302024 | 8052024 | 10-Q 6/30/2024 |
3312024 | 5082024 | 10-Q 3/31/2024 |
12312023 | 2212024 | 10-K 12/31/2023 |
9302023 | 11062023 | 10-Q 9/30/2023 |
6302023 | 8072023 | 10-Q 6/30/2023 |
3312023 | 5082023 | 10-Q 3/31/2023 |
12312022 | 2212023 | 10-K 12/31/2022 |
9302022 | 11012022 | 10-Q 9/30/2022 |
6302022 | 8082022 | 10-Q 6/30/2022 |
3312022 | 5092022 | 10-Q 3/31/2022 |
12312021 | 2152022 | 10-K 12/31/2021 |
9302021 | 11032021 | 10-Q 9/30/2021 |
Insider Activity
Expand for MoreOwner | Title | Filing Date | Action | Price | Shares | TransactedValue | Value ofHeld Shares | Form | |
---|---|---|---|---|---|---|---|---|---|
0 | Treco Douglas A | 8082025 | Buy | 57.03 | 20,000 | 1,140,600 | 1,254,660 | Form | |
1 | George Simeon | 7172025 | Buy | 52.03 | 6,510 | 338,715 | 3,625,815 | Form | |
2 | Greene John | 2282025 | Buy | 44.85 | 7,000 | 313,948 | 313,948 | Form | |
3 | Kulkarni Samarth | Chief Executive Officer | 2212025 | Sell | 55.20 | 18,360 | 1,013,564 | 9,473,896 | Form |
4 | Kulkarni Samarth | Chief Executive Officer | 12042024 | Sell | 55.10 | 15,000 | 826,564 | 10,003,635 | Form |
Industry Resources
External Quote Links
Y Finance | Barrons |
TradingView | Morningstar |
SeekingAlpha | ValueLine |
Motley Fool | Robinhood |
CNBC | Etrade |
MarketWatch | Unusual Whales |
YCharts | Perplexity Finance |
FinViz |