Tearsheet

CRISPR Therapeutics (CRSP)


Market Price (9/18/2025): $59.49 | Market Cap: $5.2 Bil
Sector: Health Care | Industry: Biotechnology

CRISPR Therapeutics (CRSP)


Market Price (9/18/2025): $59.49
Market Cap: $5.2 Bil
Sector: Health Care
Industry: Biotechnology

Investment Highlights

0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -29%
Weak multi-year price returns
2Y Excs Rtn is -28%, 3Y Excs Rtn is -76%
Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -552 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -1578%
1  Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 13
Expensive valuation multiples
P/SPrice/Sales ratio is 147x
2   Weak revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is -82%
3   Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -928%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -1002%
4   Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -14%
5   Significant short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 25%
0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -29%
1 Weak multi-year price returns
2Y Excs Rtn is -28%, 3Y Excs Rtn is -76%
2 Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 13
3 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -552 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -1578%
4 Expensive valuation multiples
P/SPrice/Sales ratio is 147x
5 Weak revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is -82%
6 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -928%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -1002%
7 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -14%
8 Significant short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 25%

Market Valuation

 9/18/252024202320222021
Share Price CYE$59.49$39.36$62.60$40.65$75.78
Market Cap CYE ($ Bil)5.23.45.03.25.8
Total Debt ($ Bil)0.20.20.20.20.2
Total Cash ($ Bil)1.71.91.71.82.4
Enterprise Value ($ Bil)3.73.65.23.46.0
Valuation Ratios     
P/S TTM148.094.913.47248.66.3
P/EBIT TTM-9.4-7.1-22.3-4.715.4
P/E TTM-11.1-9.1-32.3-4.915.2
Sector Ratios     
P/S TTM (Sector)3.83.64.14.57.3
P/EBIT TTM (Sector)-1.6-1.3-1.4-1.3-2.9
P/E TTM (Sector)-1.8-1.5-1.5-1.3-2.9
 9/18/2520242023
Share Price CYE$59.49$39.36$62.60
Market Cap CYE ($ Bil)5.23.45.0
Total Debt ($ Bil)0.20.20.2
Total Cash ($ Bil)1.71.91.7
Enterprise Value ($ Bil)3.73.65.2
Valuation Ratios   
P/S TTM148.094.913.4
P/EBIT TTM-9.4-7.1-22.3
P/E TTM-11.1-9.1-32.3
Sector Ratios   
P/S TTM (Sector)3.83.64.1
P/EBIT TTM (Sector)-1.6-1.3-1.4
P/E TTM (Sector)-1.8-1.5-1.5

Business Description

CRISPR Therapeutics AG, a gene editing company, focuses on developing gene-based medicines for serious diseases using its proprietary Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) platform. Its CRISPR/Cas9 is a gene editing technology that allows for precise directed changes to genomic DNA. The company has a portfolio of therapeutic programs across a range of disease areas, including hemoglobinopathies, oncology, regenerative medicine, and rare diseases. Show more

Price Returns Compared

Expand for Detailed View

 202020212022202320242025Total [1]
Returns
CRSP Return151%-51%-46%54%-37%50%-8%
Peers Return60%35%6%8%-6%13%159%
S&P 500 Return16%27%-19%24%23%12%104%

[1] Cumulative total returns since the beginning of 2020
[2] Peers: NTLA, ABBV, AMGN, GILD, VRTX. See CRSP Returns vs. Peers.
[3] 2025 data is for the year up to 9/17/2025 (YTD)

Better Bets than CRISPR Therapeutics (CRSP)

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Peer Comparisons for CRISPR Therapeutics

Financials

CRSPNTLAABBVAMGNGILDVRTXMedian
NameCRISPR T.Intellia.AbbVie Amgen Gilead S.Vertex P. 
Mkt Price59.0712.41220.81274.71112.26387.15166.53
Mkt Cap5.11.3390.4147.8139.899.4119.6
Rev LTM355358,32834,91728,86211,41920,140
Op Inc LTM-552-51213,6958,19210,797-1993,996
FCF LTM-351-42218,23910,6059,3693,5006,434
FCF 3Y Avg-280-39620,2738,5908,3971,9845,191
CFO LTM-325-41919,28312,0139,8683,8466,857
CFO 3Y Avg-263-38721,1549,7538,9492,3245,636

Growth & Margins

CRSPNTLAABBVAMGNGILDVRTXMedian
NameCRISPR T.Intellia.AbbVie Amgen Gilead S.Vertex P. 
Rev Chg LTM-82.5%15.0%6.1%12.9%3.8%10.5%8.3%
Rev Chg 3Y Avg380.7%6.2%0.6%10.0%1.6%11.0%8.1%
Rev Chg Q-104.8%6.6%9.4%1.8%12.1%9.4%
QoQ Delta Rev Chg LTM0.0%16.0%1.7%2.3%0.4%2.9%2.0%
Op Mgn LTM-1,578.5%-968.7%23.5%23.5%37.4%-1.7%10.9%
Op Mgn 3Y Avg-678.1%-991.9%27.2%26.4%39.2%26.5%26.5%
QoQ Delta Op Mgn LTM-223.0%218.7%1.0%1.6%-0.0%2.0%1.3%
CFO/Rev LTM-927.9%-791.9%33.1%34.4%34.2%33.7%33.4%
CFO/Rev 3Y Avg-396.8%-766.0%37.5%32.0%31.9%22.5%27.2%
FCF/Rev LTM-1,001.6%-798.0%31.3%30.4%32.5%30.6%30.5%
FCF/Rev 3Y Avg-426.2%-785.0%36.0%28.2%30.0%19.2%23.7%

Valuation

CRSPNTLAABBVAMGNGILDVRTXMedian
NameCRISPR T.Intellia.AbbVie Amgen Gilead S.Vertex P. 
Mkt Cap5.11.3390.4147.8139.899.4119.6
P/S146.924.46.74.24.88.77.7
P/EBIT-9.3-2.566.314.317.022.615.7
P/E-11.0-2.7103.722.322.127.322.2
P/CFO-15.8-3.120.212.314.225.813.2
Total Yield-9.1%-37.3%3.9%7.8%7.3%3.7%3.8%
Dividend Yield0.0%0.0%2.9%3.4%2.8%0.0%1.4%
FCF Yield 3Y Avg-6.4%-23.9%7.3%6.2%8.0%2.1%4.1%
D/E0.00.10.20.40.20.00.1
Net D/E-0.3-0.30.20.30.1-0.00.0

Returns

CRSPNTLAABBVAMGNGILDVRTXMedian
NameCRISPR T.Intellia.AbbVie Amgen Gilead S.Vertex P. 
1M Rtn2.6%15.7%6.9%-6.1%-4.2%-0.7%0.9%
3M Rtn33.0%29.3%20.1%-4.4%4.7%-13.7%12.4%
6M Rtn40.8%33.4%5.9%-11.5%5.9%-24.5%5.9%
12M Rtn18.4%-45.0%18.2%-14.7%39.2%-19.6%1.8%
3Y Rtn-16.2%-81.1%71.6%30.8%90.5%33.6%32.2%
1M Excs Rtn0.2%13.3%4.5%-8.5%-6.5%-3.0%-1.4%
3M Excs Rtn26.4%19.2%9.8%-14.8%-5.7%-22.7%2.0%
6M Excs Rtn26.6%17.5%-12.4%-29.9%-14.3%-42.0%-13.4%
12M Excs Rtn3.4%-61.1%0.4%-31.9%22.3%-37.6%-15.7%
3Y Excs Rtn-76.0%-141.5%13.2%-33.4%25.2%-28.7%-31.0%

Financials

Segment Financials

Revenue by Segment

$ Mil20242023202220212020
Developing and commercializing therapies derived from or incorporating genome-editing technology3711   
Collaboration revenue  9131290
Grant revenue  200
Total37119151290


Price Behavior

Short Interest

Short Interest: As Of Date8292025
Short Interest: Shares Quantity22,074,375
Short Interest: % Change Since 8152025-5.3%
Average Daily Volume1,738,538
Days-to-Cover Short Interest12.70
Basic Shares Quantity87,069,690
Short % of Basic Shares25.4%

Earnings Returns History

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 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
8/4/2025-6.7%-7.0%-11.1%
5/6/20253.3%12.2%16.3%
2/11/20259.3%33.8%6.0%
11/5/2024-0.5%8.4%1.1%
8/5/2024-0.7%-5.5%-9.3%
5/8/20240.5%6.9%8.6%
2/21/20244.7%13.2%-7.4%
11/6/202313.6%0.8%37.9%
...
SUMMARY STATS   
# Positive151314
# Negative91110
Median Positive5.1%12.2%11.4%
Median Negative-3.4%-7.0%-11.0%
Max Positive13.6%33.8%70.8%
Max Negative-6.7%-13.0%-34.8%

SEC Filings

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Report DateFiling DateFiling
6302025804202510-Q 6/30/2025
3312025506202510-Q 3/31/2025
12312024211202510-K 12/31/2024
93020241105202410-Q 9/30/2024
6302024805202410-Q 6/30/2024
3312024508202410-Q 3/31/2024
12312023221202410-K 12/31/2023
93020231106202310-Q 9/30/2023
6302023807202310-Q 6/30/2023
3312023508202310-Q 3/31/2023
12312022221202310-K 12/31/2022
93020221101202210-Q 9/30/2022
6302022808202210-Q 6/30/2022
3312022509202210-Q 3/31/2022
12312021215202210-K 12/31/2021
93020211103202110-Q 9/30/2021

Insider Activity

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 OwnerTitleFiling DateActionPriceSharesTransacted
Value
Value of
Held Shares
Form
0Treco Douglas A 8082025Buy57.0320,0001,140,6001,254,660Form
1George Simeon 7172025Buy52.036,510338,7153,625,815Form
2Greene John 2282025Buy44.857,000313,948313,948Form
3Kulkarni SamarthChief Executive Officer2212025Sell55.2018,3601,013,5649,473,896Form
4Kulkarni SamarthChief Executive Officer12042024Sell55.1015,000826,56410,003,635Form