Market Movers | Winners: LQDA, SCTX, ALMR | Losers: BLZE, DFH, EOSE
On Wednesday, October 14, the S&P 500 slid 1.1%, the Nasdaq-100 dropped 2.0% and the Dow Jones Industrial Average slipped 0.1%. The S&P 500 is now down 1.1% over five trading days and up 1.8% over the past month.
Within the Trefis coverage universe, 961 stocks rose and 3,150 fell. Liquidia (LQDA) gained 26.6% to lead the day, while Backblaze (BLZE) fell 22.3%, the weakest showing.

Wednesday’s Market Winners
The 10 US-listed stocks in the Trefis coverage universe worth at least $300 million with the highest returns on Wednesday:
| # | Ticker | Company Name | 1-D Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | LQDA | Liquidia | 26.6% | -1.6% |
| 2 | SCTX | Scribe Therapeutics | 8.6% | n/a |
| 3 | ALMR | Alamar Biosciences | 7.9% | n/a |
| 4 | TRAX | First Tracks Biotherapeutics | 7.7% | n/a |
| 5 | NRIX | Nurix Therapeutics | 7.0% | 24.8% |
| 6 | HALO | Halozyme Therapeutics | 6.6% | 73.6% |
| 7 | SSII | SS Innovations International | 5.9% | -52.5% |
| 8 | AADX | Applied Aerospace & Defense | 5.8% | n/a |
| 9 | PHAT | Phathom Pharmaceuticals | 5.7% | -55.4% |
| 10 | CHWY | Chewy | 5.7% | -37.0% |
Wednesday’s Market Losers
And the 10 US-listed stocks in the Trefis coverage universe worth at least $300 million with the lowest returns on Wednesday:
| # | Ticker | Company Name | 1-D Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | BLZE | Backblaze | -22.3% | 108.7% |
| 2 | DFH | Dream Finders Homes | -19.5% | -56.6% |
| 3 | EOSE | Eos Energy Enterprises | -15.9% | -83.0% |
| 4 | CRWV | CoreWeave | -15.5% | -8.1% |
| 5 | UNIT | Uniti | -15.2% | -19.5% |
| 6 | FRMI | Fermi | -15.1% | -60.5% |
| 7 | DOCN | DigitalOcean | -14.8% | 127.1% |
| 8 | WOLF | Wolfspeed | -14.0% | 41.2% |
| 9 | PENG | Penguin Solutions | -13.6% | 245.6% |
| 10 | RXT | Rackspace Technology | -13.4% | n/a |
For A Few Names, Wednesday Extended A Monthly Trend
The 15.9% decline in Eos Energy Enterprises (EOSE) on Wednesday was not a one-off: the stock is down 52.1% over the past month, and down 43.0% over the sessions before Wednesday.
Uniti (UNIT) appears on both the one-day and one-month losers lists. It fell 15.2% on Wednesday and is down 42.3% over the past month; excluding Wednesday, it had already lost 32.0% over the other sessions.
Movers Over The Last Week
Widening the window to five trading days, these are the strongest and weakest names in the Trefis coverage universe:
Winners
| # | Ticker | Company Name | 1-W Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | BMBL | Bumble | 138.8% | 67.2% |
| 2 | PCRX | Pacira BioSciences | 44.4% | 40.6% |
| 3 | FIGS | FIGS | 32.5% | 64.0% |
| 4 | LQDA | Liquidia | 27.2% | -1.6% |
| 5 | SES | SES AI | 26.1% | -49.2% |
| 6 | PTLO | Portillos | 23.0% | 2.6% |
| 7 | HAE | Haemonetics | 19.1% | 51.1% |
| 8 | SCTX | Scribe Therapeutics | 18.2% | n/a |
| 9 | CCC | CCC Intelligent Solutions | 16.6% | -3.9% |
| 10 | HPK | HighPeak Energy | 16.3% | 109.1% |
Losers
| # | Ticker | Company Name | 1-W Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | EOSE | Eos Energy Enterprises | -37.1% | -83.0% |
| 2 | CTNM | Contineum Therapeutics | -36.1% | -28.8% |
| 3 | CIFR | Cipher Digital | -31.7% | -32.7% |
| 4 | ASTS | AST SpaceMobile | -30.5% | -42.0% |
| 5 | AAOI | Applied Optoelectronics | -29.6% | 147.3% |
| 6 | BLZE | Backblaze | -29.2% | 108.7% |
| 7 | UNIT | Uniti | -28.1% | -19.5% |
| 8 | UAMY | United States Antimony | -27.7% | -44.4% |
| 9 | PACB | Pacific Biosciences of California | -26.8% | 6.4% |
| 10 | INDI | Indie Semiconductor | -26.8% | -43.2% |
Movers Over The Last Month
And over the last 21 trading days, the strongest and weakest names in the Trefis coverage universe:
Winners
| # | Ticker | Company Name | 1-M Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | BMBL | Bumble | 97.7% | 67.2% |
| 2 | QSI | Quantum-Si | 93.1% | 26.4% |
| 3 | GRAL | GRAIL | 84.1% | n/a |
| 4 | DNA | Ginkgo Bioworks | 64.9% | 38.7% |
| 5 | MRNA | Moderna | 57.4% | n/a |
| 6 | IOVA | Iovance Biotherapeutics | 51.8% | 420.5% |
| 7 | PCRX | Pacira BioSciences | 51.2% | 40.6% |
| 8 | SES | SES AI | 48.6% | -49.2% |
| 9 | PACB | Pacific Biosciences of California | 48.5% | 6.4% |
| 10 | SG | Sweetgreen | 48.5% | 50.0% |
Losers
| # | Ticker | Company Name | 1-M Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | EMAT | Evolution Metals & Technologies | -54.7% | n/a |
| 2 | EOSE | Eos Energy Enterprises | -52.1% | -83.0% |
| 3 | QURE | uniQure | -51.3% | -12.4% |
| 4 | LQDA | Liquidia | -48.4% | -1.6% |
| 5 | NKTR | Nektar Therapeutics | -44.6% | -12.7% |
| 6 | UNIT | Uniti | -42.3% | -19.5% |
| 7 | PCT | PureCycle Technologies | -42.3% | -62.5% |
| 8 | ABR | Arbor Realty Trust | -42.3% | -62.9% |
| 9 | AVBP | ArriVent BioPharma | -42.1% | -19.5% |
| 10 | CTNM | Contineum Therapeutics | -41.1% | -28.8% |
Today’s Winner Is Tomorrow’s Loser Often Enough
The movers list is the most honest picture of single-stock risk the market prints each day: the same volatility that makes the winners column also fills the losers column, and no one reliably knows which side a stock lands on next.
That is the case for owning a disciplined basket instead of chasing the tape. The Trefis High Quality (HQ) Portfolio holds roughly 30 businesses selected for consistent cash generation, strong margins, and resilient balance sheets, sized and rebalanced with rules. It has a track record of outpacing a benchmark that combines the S&P 500, the S&P MidCap 400, and the Russell 2000. Watch the movers for information; let the portfolio do the compounding.