12 Mid Cap Stocks Just Made New 52-Week Highs
As of Thursday, October 15, there are 12 Mid Cap US and Canada-listed stocks in the Trefis coverage universe trading at their 52-week highs. Mid Cap here means a market value between $10 billion and $40 billion, the upper figure excluded.
Centene (CNC), with a market value of about $34.8 billion, is the largest company on the list; its stock is up 6.8% over the past month and up 93.5% over the past year. By sector, Health Care leads the list with 5 of the 12 names. For context, the S&P 500 is up 2.6% over the past month, including dividends.

The 10 Largest, By Market Cap
The table below shows the 10 largest of the 12 names, sorted by market capitalization, with returns over four windows:
| Tickers | Market Cap |
1D Return |
1W Return |
1M Return |
1Y Return |
|---|---|---|---|---|---|
| CNC | $34.8 Bil | 0.5% | 9.3% | 6.8% | 93.5% |
| BIIB | $34.8 Bil | 1.1% | 7.7% | 9.0% | 62.0% |
| MTD | $33.0 Bil | 1.8% | 7.2% | 18.9% | 25.8% |
| EXPD | $26.0 Bil | 1.2% | 2.5% | 5.1% | 71.0% |
| IFF | $23.0 Bil | 0.8% | 6.7% | 7.5% | 49.7% |
| RGA | $17.2 Bil | 1.1% | 3.2% | 6.4% | 36.4% |
| EXEL | $15.8 Bil | 3.0% | 6.5% | 10.7% | 59.0% |
| HALO | $14.2 Bil | 4.0% | 10.6% | 12.1% | 82.3% |
| RNR | $14.2 Bil | 1.4% | 3.9% | 4.8% | 30.8% |
| MANH | $13.3 Bil | 3.1% | 9.8% | 7.0% | 13.2% |
What Sits Behind The Biggest New Highs?
Centene (CNC) grew revenue 13.9% over the last twelve months and earned an operating margin of 0.8%.
Biogen (BIIB) grew revenue 0.3% over the last twelve months and earned an operating margin of 19.3%.
Across the list, one-month moves range from +4.8% for RenaissanceRe (RNR) to +27.5% for GameStop (GME).
Over the past year, the median name here is up 43.0%.
5 of the 12 names are also S&P 500 members.
A new high tells you what the market already believes. The harder question is which of these runs management itself is underwriting. Our Guidance Momentum screen tracks exactly that: stocks where the company raised its own forward numbers.
One more pattern worth noticing: 5 of the 12 names are Health Care stocks. When a whole group is making new highs together, a health care ETF like XLV, which holds 3 of the 5 largest of them, is one way to own part of the group’s strength without betting on which single name leads it from here.
Chasing Highs Is A Reflex. Owning Strength Is A System
A 52-week-high list is seductive: everything on it has been going right. But buying a stock because it is at its high is buying a price, and prices revert; what persists is the quality underneath the run.
The Trefis High Quality (HQ) Portfolio is built to own that quality before and after it makes headlines: roughly 30 businesses selected for consistent cash generation, strong margins, and resilient balance sheets, sized and rebalanced with rules. It has a track record of outpacing a benchmark that combines the S&P 500, the S&P MidCap 400, and the Russell 2000. Admire the list; own the system.